Zobrazeno 1 - 10
of 80
pro vyhledávání: '"KEITARO HAYASHI"'
Autor:
Motoshi Ouchi, Asuka Morita, Keitaro Satoh, Shunsuke Kobayashi, Misao Terada, Hiroe Kon, Keitaro Hayashi, Tatsuya Suzuki, Kenzo Oba, Hitoshi Sugihara, Masahiro Yasutake, Naohiko Anzai, Tomoe Fujita
Publikováno v:
Journal of Pharmacological Sciences, Vol 149, Iss 2, Pp 66-72 (2022)
Organ bath experiments are conventionally used to investigate the physiological actions and effects of hormones and drugs on organ responses. We developed an experimental method to reproduce insulin secretion from isolated rat pancreas preparations,
Externí odkaz:
https://doaj.org/article/1b2bdd34a7454a31b8619adc8ad7214a
Autor:
Keitaro Hayashi, Naohiko Anzai
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 31-40 (2022)
Ingestion of amino acids is fundamental for cellular activity. Amino acids are important components for protein synthesis but are also crucial for intracellular metabolic reactions and signal transduction. Following activation, immune cells induce me
Externí odkaz:
https://doaj.org/article/92bd53b8dab344098f4b4789d597c909
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8905 (2023)
Previous studies demonstrated that hamster sperm hyperactivation is suppressed by extracellular Na+ by lowering intracellular Ca2+ levels, and Na+/Ca2+-exchanger (NCX) specific inhibitors canceled the suppressive effects of extracellular Na+. These r
Externí odkaz:
https://doaj.org/article/d0f0575f1b8c4d67a35b7bc848370722
Autor:
Osamu Kaminuma, Tomoe Nishimura, Mayumi Saeki, Norimasa Yamasaki, Sawako Ogata, Tomoe Fujita, Hitoshi Endou, Keitaro Hayashi
Publikováno v:
Allergology International, Vol 69, Iss 3, Pp 455-458 (2020)
Externí odkaz:
https://doaj.org/article/195db56ca2eb45e98ae53872920009fa
Autor:
Yasuo Shimizu, Yusuke Nakamura, Yasuhiro Horibata, Mio Fujimaki, Keitaro Hayashi, Nobuhiko Uchida, Hiroko Morita, Ryo Arai, Kazuyuki Chibana, Akihiro Takemasa, Hiroyuki Sugimoto
Publikováno v:
Regenerative Therapy, Vol 14, Iss , Pp 299-305 (2020)
Introduction: Vascular endothelial cell disorders are closely related to cardiovascular disease (CVD) and pulmonary diseases. Abnormal lipid metabolism in the endothelium leads to changes in cell signalling, and the expression of genes related to imm
Externí odkaz:
https://doaj.org/article/ad7c1b52f2cf477093eebe33aef54fa1
Autor:
Keitaro Hayashi, Osamu Kaminuma
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 553 (2022)
Bronchial asthma is a chronic disease characterized by airway inflammation, obstruction, and hyperresponsiveness. CD4+ T cells, particularly T helper (Th) 2 cells, and their specific cytokines are important mediators in asthma pathogenesis. However,
Externí odkaz:
https://doaj.org/article/39ef809a5d744513beeb28876b4f3c54
Autor:
Keitaro Hayashi, Promsuk Jutabha, Sumiko Maeda, Yothaisong Supak, Motoshi Ouchi, Hitoshi Endou, Tomoe Fujita, Masayuki Chida, Naohiko Anzai
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 3, Pp 201-204 (2016)
L-type amino acid transporter 1 (LAT1, SLC7A5) incorporates essential amino acids into cells. Recent studies have shown that LAT1 is a predominant transporter in various human cancers. However, the function of LAT1 in thymic carcinoma remains unknown
Externí odkaz:
https://doaj.org/article/6058706be7b249baabd7f8730bb9aec4
Autor:
Supak Yothaisong, Hasaya Dokduang, Naohiko Anzai, Keitaro Hayashi, Nisana Namwat, Puangrat Yongvanit, Sakkarn Sangkhamanon, Promsuk Jutabha, Hitoshi Endou, Watcharin Loilome
Publikováno v:
Tumor Biology, Vol 39 (2017)
Unlike normal cells, cancer cells undergo unlimited growth and multiplication, causing them to require massive amounts of amino acid to support their continuous metabolism. Among the amino acid transporters expressed on the plasma membrane, l- type a
Externí odkaz:
https://doaj.org/article/9616945517e249faa6e4ebd289cf1434
Autor:
Promsuk Jutabha, Naohiko Anzai, Keitaro Hayashi, Mariko Domae, Kohsuke Uchida, Hitoshi Endou, Hiroyuki Sakurai
Publikováno v:
Journal of Pharmacological Sciences, Vol 116, Iss 4, Pp 392-396 (2011)
Abstract.: In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system. hNPT4 mediated time- and concentration-dependent
Externí odkaz:
https://doaj.org/article/942cca8f029c41d3b09025d93dad73e8
Publikováno v:
Journal of Pharmacological Sciences, Vol 124, Iss 4, Pp 511-513 (2014)
Endothelial cell proliferation supporting angiogenesis requires sufficient nutrient supply because of facilitated intracellular metabolism. However, little is known about the mechanism for the promotion of nutrient incorporation in proliferating endo
Externí odkaz:
https://doaj.org/article/c2a3875444b84ecdbadb537940485fcb