Zobrazeno 1 - 10 of 49 pro vyhledávání: '"KD025"'
1
Akademický článek
The Specific ROCK2 Inhibitor KD025 Alleviates Glycolysis through Modulating STAT3-, CSTA- and S1PR3-Linked Signaling in Human Trabecular Meshwork Cells
Autor: Megumi Watanabe, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa, Nami Nishikiori, Megumi Suzuki, Masato Furuhashi, Hiroshi Ohguro
Publikováno v: Biomedicines, Vol 12, Iss 6, p 1165 (2024)
To investigate the biological significance of Rho-associated coiled-coil-containing protein kinase (ROCK) 2 in the human trabecular meshwork (HTM), changes in both metabolic phenotype and gene expression patterns against a specific ROCK2 inhibitor KD
Externí odkaz: https://doaj.org/article/510c4eac2fe64ff3b93fe2ab9b804fd2
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2
Akademický článek
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3
Akademický článek
KD025 (SLx-2119) suppresses adipogenesis at intermediate stage in human adipose-derived stem cells
Autor: Duy Trong Vien Diep, Khue Ha Minh Duong, Hojung Choi, Hee-Sook Jun, Kwang-Hoon Chun
Publikováno v: Adipocyte, Vol 8, Iss 1, Pp 114-124 (2019)
Rho-associated kinases (ROCKs) have been reported to antagonize adipocyte differentiation, and inhibition of ROCKs by small molecules promotes adipogenesis. Surprisingly, our recent study revealed that the ROCK2-specific inhibitor KD025 (SLx-2119), s
Externí odkaz: https://doaj.org/article/39e39f5cb9c3476aa29a1826041717a1
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4
Akademický článek
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5
Akademický článek
Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners
Autor: Megumi Watanabe, Yosuke Ida, Masato Furuhashi, Yuri Tsugeno, Fumihito Hikage, Hiroshi Ohguro
Publikováno v: Molecules, Vol 26, Iss 21, p 6382 (2021)
Effects of a pan-ROCK-inhibitor, ripasudil (Rip), and a ROCK2 inhibitor, KD025 on dexamethasone (DEX)-treated human trabecular meshwork (HTM) cells as a model of steroid-induced glaucoma were investigated. In the presence of Rip or KD025, DEX-treated
Externí odkaz: https://doaj.org/article/87169559e7f3417f91f53c735e7bf2e0
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6
Akademický článek
ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2
Autor: Nhu Nguyen Quynh Tran, Kwang-Hoon Chun
Publikováno v: Molecules, Vol 26, Iss 16, p 4747 (2021)
KD025, a ROCK2 isoform-specific inhibitor, has an anti-adipogenic activity which is not mediated by ROCK2 inhibition. To identify the target, we searched binding targets of KD025 by using the KINOMEscanTM screening platform, and we identified casein
Externí odkaz: https://doaj.org/article/3ca41d4db52349b181cb1ee0d0111c41
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7
Akademický článek
Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Pharmacokinetic Application
Autor: Jin-Ha Yoon, Thi-Thao-Linh Nguyen, Van-An Duong, Kwang-Hoon Chun, Han-Joo Maeng
Publikováno v: Molecules, Vol 25, Iss 6, p 1369 (2020)
KD025 (SLx-2119), the first specific Rho-associated protein kinase 2 (ROCK2) inhibitor, is a potential new drug candidate currently undergoing several phase 2 clinical trials for psoriasis, idiopathic pulmonary fibrosis, chronic graft-versus-host dis
Externí odkaz: https://doaj.org/article/27fcb2ec0e874b25b4d8961c8cf3a315
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8
Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners
Autor: Hiroshi Ohguro, Yosuke Ida, Megumi Watanabe, Masato Furuhashi, Fumihito Hikage, Yuri Tsugeno
Publikováno v: Molecules
Volume 26
Issue 21
Molecules, Vol 26, Iss 6382, p 6382 (2021)
Effects of a pan-ROCK-inhibitor, ripasudil (Rip), and a ROCK2 inhibitor, KD025 on dexamethasone (DEX)-treated human trabecular meshwork (HTM) cells as a model of steroid-induced glaucoma were investigated. In the presence of Rip or KD025, DEX-treated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483fef68df8fc0899f35ee27ce2bbb87
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9
ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2
Autor: Kwang-Hoon Chun, Nhu Nguyen Quynh Tran
Publikováno v: Molecules
Volume 26
Issue 16
Molecules, Vol 26, Iss 4747, p 4747 (2021)
KD025, a ROCK2 isoform-specific inhibitor, has an anti-adipogenic activity which is not mediated by ROCK2 inhibition. To identify the target, we searched binding targets of KD025 by using the KINOMEscanTM screening platform, and we identified casein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158ef94e3e3e0c7fe7470678ebc72157
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10
Rosiglitasone and ROCK Inhibitors Modulate Fibrogenetic Changes in TGF-β2 Treated Human Conjunctival Fibroblasts (HconF) in Different Manners
Autor: Yosuke Ida, Fumihito Hikage, Yuika Oouchi, Hiroshi Ohguro, Megumi Watanabe
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences, Vol 22, Iss 7335, p 7335 (2021)
Purpose: The effects of Rho-associated coiled-coil containing protein kinase (ROCK) 1 and 2 inhibitor, ripasudil hydrochloride hydrate (Rip), ROCK2 inhibitor, KD025 or rosiglitazone (Rosi) on two-dimension (2D) and three-dimension (3D) cultured human
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f22a3286acc0c8269fc6614d22a11dc
http://europepmc.org/articles/PMC8307967
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