Zobrazeno 1 - 5
of 5
pro vyhledávání: '"KD, kinase domain"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Multiple cancer immunotherapies including chimeric antigen receptor T cell and immune checkpoint inhibitors (ICIs) have been successfully developed to treat various cancers by motivating the adaptive anti-tumor immunity. Particularly, the checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c604607610f05b2d37da5b2cce00382
http://www.sciencedirect.com/science/article/pii/S2211383519316946
http://www.sciencedirect.com/science/article/pii/S2211383519316946
Publikováno v:
Seminars in Cell & Developmental Biology
Receptor Interacting Protein Kinases (RIPKs) are cellular signaling molecules that are critical for homeostatic signaling in both communicable and non-communicable disease processes. In particular, RIPK1, RIPK2, RIPK3 and RIPK7 have emerged as key me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628bb448c2d6de5b9d7755cdadd35794
http://europepmc.org/articles/PMC7448748
http://europepmc.org/articles/PMC7448748
Autor:
Huifang Xu, Angela Paul, Leo S. Payne, Scott Gridley, Edward A. Esposito, Maciej T. Luczynski, Paul H. Huang, Francis Chang, Birgit Leitinger, Ryan W. Clinton, Leo Kei Iwai, Kristen M. Naegle
Publikováno v:
Biochemical Journal
Collagen is an important extracellular matrix component that directs many fundamental cellular processes including differentiation, proliferation and motility. The signalling networks driving these processes are propagated by collagen receptors such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c387521eaf5d495273f18ce098d2aa9
http://europepmc.org/articles/PMC3893797
http://europepmc.org/articles/PMC3893797
Autor:
Peter Sheldrake, Samerene Siddique, Cornelis Matijssen, Julian Blagg, M. Cris Silva-Santisteban, Vanessa Choi, Rob L. M. van Montfort, Isaac M. Westwood
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract Unconstrained rigid docking, flexible side chain docking and protein crystal structure determinations reveal a water-mediated hinge binding mode for a series of benzimidazole ligands of the protein kinase CHK2. This binding mode is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4bcc2c2a7d392f546b3e72ddc09573
https://doi.org/10.1016/j.bmc.2012.09.024
https://doi.org/10.1016/j.bmc.2012.09.024
Autor:
Ding C; Research Laboratory of Medicinal Chemical Biology & Frontiers on Drug Discovery (RLMCBFDD), School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Song Z; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Shen A; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Chen T; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Zhang A; Research Laboratory of Medicinal Chemical Biology & Frontiers on Drug Discovery (RLMCBFDD), School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China.; University of Chinese Academy of Sciences, Beijing 100049, China.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Dec; Vol. 10 (12), pp. 2272-2298. Date of Electronic Publication: 2020 Mar 13.