Targeting hydrogen sulphide signaling in breast cancer

Autor: Nabil Ahmed, Khaled Sanber, Mohamed Z. Gad, Ahmed Z. Gad, Hafez Mohamed Hafez, Amira Abdel Motaal, Rana Ahmed Youness, Emad Khallaf, Gi-Ja Lee, Yong Jin Ahn

Publikováno v: Journal of Advanced Research
Journal of Advanced Research, Vol 27, Iss, Pp 177-190 (2021)

Graphical abstract
Introduction Hydrogen sulphide (H2S) has been established as a key member of the gasotransmitters family that recently showed a pivotal role in various pathological conditions including cancer. Objectives This study investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ff83ab0e4869a509813e452dab4a54
https://doi.org/10.1016/j.jare.2020.07.006

Transcriptional regulation of miR-30a by YAP impacts PTPN13 and KLF9 levels and Schwann cell proliferation

Autor: Sany Hoxha, David Harbaugh, Scott Troutman, Michael S. Kareta, Joseph L. Kissil, Alyssa Shepard

Publikováno v: The Journal of Biological Chemistry

The Hippo pathway is a key regulatory pathway that is tightly regulated by mechanical cues such as tension, pressure, and contact with the extracellular matrix and other cells. At the distal end of the pathway is the yes-associated protein (YAP), a w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b74cf5d914eb1255b98445949c86bd1
http://europepmc.org/articles/PMC8348554

Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway

Autor: Yingxia Liu, Jiang Zhu, Yu Xia, Ming-Tat Ling, George L. Tipoe, Jia Xiao, Xiaogang Wang, Feiyue Xing, Yi Lv, Hao Gao, Min Yang, Kwok-Fai So, Songying Ouyang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 8, Iss 4, Pp 575-586 (2018)

Whether and how garlic-derived S-allylmercaptocysteine (SAMC) inhibits hepatocellular carcinoma (HCC) is largely unknown. In the current study, the role of low-density lipoprotein receptor (LDLR)-related protein 6 (LRP6) in HCC progression and the an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7ba21d8627d51d0afb2b48fadc1d2a
http://europepmc.org/articles/PMC6090075

Munc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells

Autor: Herbert Y. Gaisano, Ya-Chi Huang, Dan Zhu, Youhou Kang, Li Xie, Tao Liang, Negar Karimian

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 4, Iss 5, Pp 418-426 (2015)

Objective: Pancreatic beta-cells express three Munc18 isoforms. Much is known about the roles of Munc18a (pre-docked secretory granules-SGs) and Munc18b (newcomer SGs and SG–SG fusion) in insulin exocytosis. Although shown to influence glucose-stim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e041ffa5cb48ee0df720f36e09427b0d
https://pubmed.ncbi.nlm.nih.gov/25973389

Targeting hydrogen sulphide signaling in breast cancer.

Autor: Youness RA; Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt., Gad AZ; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA., Sanber K; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Ahn YJ; Department of Medical Engineering, Graduate School, Kyung Hee University, Seoul 130-701, Republic of Korea.; Department of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea., Lee GJ; Department of Medical Engineering, Graduate School, Kyung Hee University, Seoul 130-701, Republic of Korea.; Department of Biomedical Engineering, College of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea., Khallaf E; Department of General Surgery, Faculty of Medicine, Cairo University, 12613 Cairo, Egypt., Hafez HM; Department of General Surgery, Faculty of Medicine, Cairo University, 12613 Cairo, Egypt., Motaal AA; Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Egypt., Ahmed N; Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX 77030, USA.; Center for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA., Gad MZ; Department of Biochemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Egypt.

Publikováno v: Journal of advanced research [J Adv Res] 2020 Jul 16; Vol. 27, pp. 177-190. Date of Electronic Publication: 2020 Jul 16 (Print Publication: 2021).