Výsledky vyhledávání - "KCa3.1 channel"

Akademický článek

Reduction of Ca2+ Entry by a Specific Block of KCa3.1 Channels Optimizes Cytotoxic Activity of NK Cells against T-ALL Jurkat Cells

Autor: Miguel Olivas-Aguirre, Laura Hadit Cruz-Aguilar, Igor Pottosin, Oxana Dobrovinskaya

Publikováno v: Cells, Vol 12, Iss 16, p 2065 (2023)

Degranulation mediated killing mechanism by NK cells is dependent on store-operated Ca2+ entry (SOCE) and has optimum at moderate intracellular Ca2+ elevations so that partial block of SOCE optimizes the killing process. In this study, we tested the

Externí odkaz: https://doaj.org/article/0f6075c8d7b245f0a6960e22af3f35fe

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Akademický článek

Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases

Autor: Sijian Wang, Biyao Wang, Dehao Shang, Kaige Zhang, Xu Yan, Xinwen Zhang

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Astrocytes play an important role in the central nervous system (CNS). Ion channels in these cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but also participate in physiological processes of neurons and glial

Externí odkaz: https://doaj.org/article/52c6cd2e25c440e3a38935eadfeea5f5

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Akademický článek

Inhibition of KCa3.1 Channels Suppresses Atrial Fibrillation via the Attenuation of Macrophage Pro-inflammatory Polarization in a Canine Model With Prolonged Rapid Atrial Pacing

Autor: Shanqing He, Youcheng Wang, Yajun Yao, Zhen Cao, Junkui Yin, Liuliu Zi, Huiyu Chen, Yuntao Fu, Xi Wang, Qingyan Zhao

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Aims: To investigate the role of KCa3. 1 inhibition in macrophage pro-inflammatory polarization and vulnerability to atrial fibrillation (AF) in a canine model with prolonged rapid atrial pacing.Materials and Methods: Twenty beagle dogs (weighing 8�

Externí odkaz: https://doaj.org/article/f6158f5bf90e48a28ccdffbc3d3016d4

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Akademický článek

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Co‐staining of KCa3.1 Channels in NSCLC Cells with a Small‐Molecule Fluorescent Probe and Antibody‐Based Indirect Immunofluorescence

Autor: Sarah Maskri, Etmar Bulk, Oliver Koch, Kathrin Brömmel, Zoltán Pethő, Bernhard Wünsch, Albrecht Schwab, Thomas Budde, Marius Rieke

Publikováno v: Chemmedchem

The Ca2+ activated potassium channel 3.1 (KCa3.1) is involved in critical steps of the metastatic cascade, such as proliferation, migration, invasion and extravasation. Therefore, a fast and efficient protocol for imaging of KCa3.1 channels was envis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278ac8e0c506edd5a4f81776a7f26bda
http://europepmc.org/articles/PMC7756743

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A critical role of the KCa3.1 channel in mechanical stretch‐induced proliferation of rat bone marrow‐derived mesenchymal stem cells

Autor: Chao Gao, Lin-Hua Jiang, Xianghui Gong, Xinlan Chen, Pei Ji, Yangbi Huang, Yan Huang, Xiaoling Jia, Hao Su, Yufan Zheng, Yubo Fan

Publikováno v: Journal of Cellular and Molecular Medicine

Mechanical stimulation is an important factor regulating mesenchymal stem cell (MSC) functions such as proliferation. The Ca2+‐activated K+ channel, KCa3.1, is critically engaged in MSC proliferation but its role in mechanical regulation of MSC pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d360ab3f562443a1fb2df9178b0ceb
http://europepmc.org/articles/PMC7131943

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Akademický článek

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Akademický článek

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Ion Channel Dysfunction in Astrocytes in Neurodegenerative Diseases

Autor: Sijian Wang, Biyao Wang, Dehao Shang, Kaige Zhang, Xu Yan, Xinwen Zhang

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3105218f49e69f99796230d1c7cb5479
https://pubmed.ncbi.nlm.nih.gov/35222082

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Effect of the KCa3.1 blocker, senicapoc, on cerebral edema and cardiovascular function after cardiac arrest — A randomized experimental rat study

Autor: Asger Granfeldt, Thomas H. Mattson, Ulf Simonsen, Niels Jørgen Secher, Bo Løfgren, Frederik Boe Hansen

Publikováno v: Resuscitation Plus, Vol 6, Iss, Pp 100111-(2021)
Resuscitation Plus
Hansen, F B, Secher, N, Mattson, T, Løfgren, B, Simonsen, U & Granfeldt, A 2021, ' Effect of the KCa3.1 blocker, senicapoc, on cerebral edema and cardiovascular function after cardiac arrest — A randomized experimental rat study ', Resuscitation Plus, vol. 6, 100111 . https://doi.org/10.1016/j.resplu.2021.100111

Highlights • Senicapoc was successfully administered intravenously. • Senicapoc did not reduce cerebral edema 4 h after cardiac arrest. • Senicapoc did not increase mean arterial pressure within 4 h from resuscitation.
Aim Formation of cer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd4cf1b9c8034bd812126d6331b5e10
http://www.sciencedirect.com/science/article/pii/S2666520421000369

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