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pro vyhledávání: '"KCa2"'
Akademický článek
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Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1780 (2023)
K+ channels are involved in many critical functions in lung physiology. Recently, the family of Ca2+-activated K+ channels (KCa) has received more attention, and a massive amount of effort has been devoted to developing selective medications targetin
Externí odkaz:
https://doaj.org/article/3c020c35823c4a62aa96542fbdbe1ffb
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 37, Iss , Pp 100898- (2021)
Background: Atrial dilation is an important risk factor for atrial fibrillation (AF) and animal studies have found that acute atrial dilation shortens the atrial effective refractory period (AERP) and increases the risk of AF. Stretch activated ion c
Externí odkaz:
https://doaj.org/article/82411e8ecce4417c847b406d7fefec9e
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Carlotta Citerni, Jeppe Kirchhoff, Lisbeth Høier Olsen, Stefan Michael Sattler, Morten Grunnet, Nils Edvardsson, Bo Hjorth Bentzen, Jonas Goldin Diness
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundInhibition of KCa2 channels, conducting IKCa, can convert atrial fibrillation (AF) to sinus rhythm and protect against its induction. IKCa inhibition has been shown to possess functional atrial selectivity with minor effects on ventricles.
Externí odkaz:
https://doaj.org/article/a086a10d016b44ba86aca26b558f382f
Autor:
Jonas Goldin Diness, Lea Abildgaard, Sofia Hammami Bomholtz, Mark Alexander Skarsfeldt, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundHypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents.Small conductan
Externí odkaz:
https://doaj.org/article/20be621c8ddb4634a78c173606c22392
Autor:
Bo Hjorth Bentzen, Sofia Hammami Bomholtz, Rafel Simó-Vicens, Lasse Folkersen, Lea Abildgaard, Tobias Speerschneider, Kalai Mangai Muthukumarasamy, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Jonas Goldin Diness
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
AimsSmall conductance Ca2+-activated K+ channels (SK channels, KCa2) are a new target for treatment of atrial fibrillation (AF). AP30663 is a small molecule inhibitor of KCa2 channels that is currently in clinical development for treatment of AF. The
Externí odkaz:
https://doaj.org/article/f462fdae02ad4e698282f8bd9227d4e9
Autor:
Jonas Goldin Diness, Jeppe Egedal Kirchhoff, Tobias Speerschneider, Lea Abildgaard, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet, Bo Hjorth Bentzen
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
AimsTo describe the effects of the KCa2 channel inhibitor AP30663 in pigs regarding tolerability, cardiac electrophysiology, pharmacokinetics, atrial functional selectivity, effectiveness in cardioversion of tachy-pacing induced vernakalant-resistant
Externí odkaz:
https://doaj.org/article/5c0147df7d244338b19b09ac7b4cb339
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
A variety of polycyclic pyridines have been proposed as inhibitors of the small conductance calcium-activated potassium (SK) channel. To this group belongs 2,6-bis(2-benzimidazolyl)pyridine (BBP), a commercially and readily available small organic co
Externí odkaz:
https://doaj.org/article/d72356213dd44457a08fa507a592b688
Autor:
Adéla Tiffner, Isabella Derler
Publikováno v:
Membranes, Vol 10, Iss 12, p 425 (2020)
Ca2+ ions play a variety of roles in the human body as well as within a single cell. Cellular Ca2+ signal transduction processes are governed by Ca2+ sensing and Ca2+ transporting proteins. In this review, we discuss the Ca2+ and the Ca2+-sensing ion
Externí odkaz:
https://doaj.org/article/07a3a874de864519b26a187e999c6352