Lipophilic compounds restore function to neurodevelopmental-associated KCNQ3 mutations.

Autor: Edmond MA; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.; Texas A&M University Health Science Center, Department of Neuroscience & Experimental Therapeutics, Bryan, USA., Hinojo-Perez A; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA., Efrem M; Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Yi-Chun L; Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Shams I; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA., Hayoz S; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.; Department of Physiology, University of Arizona, Tucson, USA., de la Cruz A; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.; Linkoping University, Department of Biomedical and Clinical Sciences (BKV), Linkoping, Sweden., Perez Rodriguez ME; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA., Diaz-Solares M; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA., Dykxhoorn DM; John P. Hussman Institute for Human Genomics, John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA., Luo YL; Department of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA., Barro-Soria R; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA. rbarro@med.miami.edu.

Publikováno v: Communications biology [Commun Biol] 2024 Sep 19; Vol. 7 (1), pp. 1181. Date of Electronic Publication: 2024 Sep 19.

Selective KCNQ2/3 Potassium Channel Opener ICA-069673 Inhibits Excitability in Mouse Vagal Sensory Neurons.

Autor: Sun H; Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland huisun@jhu.edu., Undem BJ; Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2024 Mar 15; Vol. 389 (1), pp. 118-127. Date of Electronic Publication: 2024 Mar 15.

Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity.

Autor: Tian G; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Bartas K; Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA, USA., Hui M; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Chen L; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Vasquez JJ; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Azouz G; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Derdeyn P; Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA, USA., Manville RW; Bioelectricity Laboratory, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Ho EL; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Fang AS; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Li Y; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Tyler I; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Setola V; Department of Neuroscience, West Virginia University, Morgantown, WV, USA; Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, USA., Aoto J; University of Colorado Anschutz School of Medicine, Department of Pharmacology, Aurora, CO, USA., Abbott GW; Bioelectricity Laboratory, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Beier KT; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA. Electronic address: kbeier@uci.edu.

Publikováno v: Neuron [Neuron] 2024 Oct 23; Vol. 112 (20), pp. 3470-3485.e12. Date of Electronic Publication: 2024 Aug 16.

Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain.

Autor: Zhang ZX; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China., Tian Y; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China & National Health Commission of China, Beijing, 100191, China., Li S; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China., Jing HB; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China., Cai J; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China & National Health Commission of China, Beijing, 100191, China., Li M; Department of Anesthesiology, Peking University Third Hospital, Beijing, 100191, China. liminanesth@bjmu.edu.cn., Xing GG; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China. ggxing@bjmu.edu.cn.; Key Laboratory for Neuroscience, Ministry of Education of China & National Health Commission of China, Beijing, 100191, China. ggxing@bjmu.edu.cn.

Publikováno v: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Aug 27; Vol. 22 (1), pp. 416. Date of Electronic Publication: 2024 Aug 27.

The role of KCNQ channel activators in management of major depressive disorder.

Autor: Meshkat S; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada., Kwan ATH; Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: angela.kwan@mail.utoronto.ca., Le GH; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada. Electronic address: hanny.le@mail.utoronto.ca., Wong S; Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada; Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address: sabrinal.wong@mail.utoronto.ca., Rhee TG; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Public Health Sciences, Farmington, CT, USA. Electronic address: taeho.rhee@yale.edu., Ho R; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore. Electronic address: pcmrhcm@nus.edu.sg., Teopiz KM; Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada. Electronic address: kayla.teopiz@mail.utoronto.ca., Cao B; Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University, Chongqing 400715, PR China. Electronic address: bingcao@swu.edu.cn., McIntyre RS; Brain and Cognition Discovery Foundation, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address: roger.mcintyre@bcdf.org.

Publikováno v: Journal of affective disorders [J Affect Disord] 2024 Aug 15; Vol. 359, pp. 364-372. Date of Electronic Publication: 2024 May 19.