Establishment of a transgene-free iPS cell line (SDCHi008-A) from a young patient bearing a KCNQ2 mutation and suffering from Epilepsy.

Autor: Zhang H; Neurology Department, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Neurology Department, Jinan Children's Hospital, Jinan, Shandong 250022, China; Epilepsy Center, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Epilepsy Center, Jinan Children's Hospital, Jinan, Shandong 250022, China., Zhang Q; Epilepsy Center, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Epilepsy Center, Jinan Children's Hospital, Jinan, Shandong 250022, China., Chen X; Neonatology Department, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Neonatology Department, Jinan Children's Hospital, Jinan, Shandong 250022, China., Wang M; Epilepsy Center, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Epilepsy Center, Jinan Children's Hospital, Jinan, Shandong 250022, China., Li L; Epilepsy Center, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Epilepsy Center, Jinan Children's Hospital, Jinan, Shandong 250022, China., Yu C; Neurology Department, Children's Hospital Affiliated to Shandong University, Jinan, Shandong 250022, China; Neurology Department, Jinan Children's Hospital, Jinan, Shandong 250022, China. Electronic address: m15806674066@163.com.

Publikováno v: Stem cell research [Stem Cell Res] 2024 Oct; Vol. 80, pp. 103507. Date of Electronic Publication: 2024 Jul 24.

Novel KCNQ2 missense variant expands the genotype spectrum of DEE7.

Autor: Wang C; Department of Neurology, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China., Zhai J; Department of Neurology, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China., Chen Y; Department of Neurology, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, China. 2630043341@qq.com.

Publikováno v: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2024 Nov; Vol. 45 (11), pp. 5481-5488. Date of Electronic Publication: 2024 Jun 17.

Discovery of a novel K V 7.2/7.3 channels agonist for the treatment of neuropathic pain.

Autor: Qian K; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Zhou J; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Xiong J; Medicine Center, Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006, China., Wang Q; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Chen L; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Zhuang T; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Jin J; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Zhang G; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Hao C; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: 2022000085@jou.edu.cn., Huang L; Grand Medical Nutrition Science (Wuhan) Co., LTD., Wuhan, 430040, China. Electronic address: huangcjia@126.com., Chen Y; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: 2019000015@jou.edu.cn.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116953. Date of Electronic Publication: 2024 Oct 12.

Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription repression activated by EREG/EGFR-ERK-Runx1 signaling in bone cancer pain.

Autor: Zhang ZX; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China., Tian Y; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China & National Health Commission of China, Beijing, 100191, China., Li S; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China., Jing HB; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China., Cai J; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China.; Key Laboratory for Neuroscience, Ministry of Education of China & National Health Commission of China, Beijing, 100191, China., Li M; Department of Anesthesiology, Peking University Third Hospital, Beijing, 100191, China. liminanesth@bjmu.edu.cn., Xing GG; Department of Neurobiology, School of Basic Medical Sciences, Peking University Health Science Center and Neuroscience Research Institute, Peking University, Beijing, China. ggxing@bjmu.edu.cn.; Key Laboratory for Neuroscience, Ministry of Education of China & National Health Commission of China, Beijing, 100191, China. ggxing@bjmu.edu.cn.

Publikováno v: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Aug 27; Vol. 22 (1), pp. 416. Date of Electronic Publication: 2024 Aug 27.

A small-molecule activation mechanism that directly opens the KCNQ2 channel.

Autor: Zhang S; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., Ma D; Department of Biophysics, and Department of Neurology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Wang K; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., Li Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., Yang Z; Department of Biophysics, and Department of Neurology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Li X; Department of Biophysics, and Department of Neurology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Li J; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., He J; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., Mei L; Suzhou Institute of Drug Innovation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Suzhou, China., Ye Y; Suzhou Institute of Drug Innovation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Suzhou, China., Chen Z; Department of Neurology, Wuhu Hospital Affiliated to East China Normal University, Wuhu, China., Shen J; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China., Hou P; Dr Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China., Guo J; Department of Biophysics, and Department of Neurology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. jiangtaoguo@zju.edu.cn., Zhang Q; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. qszhang@bio.ecnu.edu.cn., Yang H; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. hyyang@bio.ecnu.edu.cn.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2024 Jul; Vol. 20 (7), pp. 847-856. Date of Electronic Publication: 2024 Jan 02.