PUFA stabilizes a conductive state of the selectivity filter in IKs channels.

Autor: Golluscio A; Department of Physiology and Biophysics, University of Miami, Miami, United States.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Eldstrom J; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada., Jowais JJ; Department of Physiology and Biophysics, University of Miami, Miami, United States., Perez ME; Department of Physiology and Biophysics, University of Miami, Miami, United States., Cunningham KP; Department of Physiology and Biophysics, University of Miami, Miami, United States.; School of Life Sciences, University of Westminster, London, United Kingdom., De La Cruz A; Department of Physiology and Biophysics, University of Miami, Miami, United States.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden., Wu X; Department of Physiology and Biophysics, University of Miami, Miami, United States., Corradi V; Department of Biological Sciences and Centre for Molecular Simulation, University of Calgary, Calgary, Canada., Tieleman DP; Department of Biological Sciences and Centre for Molecular Simulation, University of Calgary, Calgary, Canada., Fedida D; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada., Larsson HP; Department of Physiology and Biophysics, University of Miami, Miami, United States.; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Publikováno v: ELife [Elife] 2024 Oct 31; Vol. 13. Date of Electronic Publication: 2024 Oct 31.

Targeting the I Ks Channel PKA Phosphorylation Axis to Restore Its Function in High-Risk LQT1 Variants.

Autor: Zhong L; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Yan Z; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Jiang D; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Weng KC; Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO (K.-C.W., J.R.S.)., Ouyang Y; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Zhang H; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Lin X; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Xiao C; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Yang H; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University (H.Y.)., Yao J; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Frontier Science Center for Immunology and Metabolism, Wuhan University, China (J.Y.)., Kang X; Key Laboratory of Medical Electrophysiology, Ministry of Education of China, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease and the Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China (X.K.).; Department of Neurosurgery, the Affiliated Hospital of Southwest Medical University, Luzhou, China (X.K.).; College of Life Sciences, Liaocheng University, China (X.K.)., Wang C; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Department of Neurology, First Affiliated Hospital, Neuroscience Research Center, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, China (C.W.)., Huang C; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Shen B; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Chung SK; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Jiang ZH; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Zhu W; Cardiovascular Medicine Division and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (W.Z.)., Neher E; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.)., Silva JR; Department of Biomedical Engineering, Center for the Investigation of Membrane Excitability Disorders, Cardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO (K.-C.W., J.R.S.)., Hou P; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute. Zhuhai, Guangdong, China (L.Z., Z.Y., D.J., Y.O., H.Z., X.L., C.X., C.H., B.S., S.K.C., Z.-H.J., E.N., P.H.).

Publikováno v: Circulation research [Circ Res] 2024 Sep 13; Vol. 135 (7), pp. 722-738. Date of Electronic Publication: 2024 Aug 21.

Novel associations between KCNQ1 rs231840 polymorphism and preeclampsia in Chinese gestational women: A case-control candidate genetic study.

Autor: Ma L; Department of Gynecology and Obstetrics Center, the First Hospital of Jilin University, Jilin, China., Ma R; Department of Obstetrics, Maternal and Child Health Hospital of Ningxia Hui Autonomous Region, Yinchuan, China., Ran R; Department of Gynecology and Obstetrics Center, the First Hospital of Jilin University, Jilin, China., Li J; Department of Research and Development, Yinfeng Biological Engineering Technology Company Limited, Jilin, China., Pan X; Department of Gynecology and Obstetrics Center, the First Hospital of Jilin University, Jilin, China., Guo Z; Department of Gynecology and Obstetrics Center, the First Hospital of Jilin University, Jilin, China., Lin X; Affiliated Middle School to Jilin University, Jilin, China., Wen D; Department of Medical Genetics, College of Basic Medical Sciences, Jilin University, China., Wu S; Department of Gynecology and Obstetrics Center, the First Hospital of Jilin University, Jilin, China., Chen Y; Department of Gynecology and Obstetrics Center, the First Hospital of Jilin University, Jilin, China.

Publikováno v: Medicine [Medicine (Baltimore)] 2024 Oct 11; Vol. 103 (41), pp. e39778.

KCNQ1 suppression-replacement gene therapy in transgenic rabbits with type 1 long QT syndrome.

Autor: Bains S; Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics, Divisions of Heart Rhythm Services and Pediatric Cardiology, Windland Smith Rice Genetic Heart Rhythm Clinic and The Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Guggenheim 501, Rochester, MN 55905, USA., Giammarino L; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Nimani S; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Alerni N; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Tester DJ; Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics, Divisions of Heart Rhythm Services and Pediatric Cardiology, Windland Smith Rice Genetic Heart Rhythm Clinic and The Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Guggenheim 501, Rochester, MN 55905, USA., Kim CSJ; Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics, Divisions of Heart Rhythm Services and Pediatric Cardiology, Windland Smith Rice Genetic Heart Rhythm Clinic and The Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Guggenheim 501, Rochester, MN 55905, USA., Christoforou N; Formerly from the Rare Disease Research Unit, Pfizer Inc., Cambridge, MA, USA., Louradour J; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Horváth A; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Beslac O; Department of Cardiology, University Hospital Bern, University of Bern, Bern, Switzerland., Barbieri M; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Matas L; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Hof TS; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Lopez R; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland., Perez-Feliz S; Department of Cardiology, University Heart Center, University Hospital Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany., Parodi C; Experimental Surgical Facility, Experimental Animal Center, University of Bern, Bern, Switzerland., Garcia Casalta LG; Experimental Surgical Facility, Experimental Animal Center, University of Bern, Bern, Switzerland., Jurgensen J; Department of Virology & Gene Therapy, Vector and Vaccine Engineering Laboratory, Mayo Clinic, Rochester, USA., Barry MA; Department of Virology & Gene Therapy, Vector and Vaccine Engineering Laboratory, Mayo Clinic, Rochester, USA., Bego M; Formerly from Biomedicine Design, Pfizer Inc., Cambridge, MA, USA., Keyes L; Formerly from Biomedicine Design, Pfizer Inc., Cambridge, MA, USA., Owens J; Formerly from the Rare Disease Research Unit, Pfizer Inc., Cambridge, MA, USA., Pinkstaff J; Drug Safety Research & Development, Pfizer Inc., Cambridge, MA, USA., Koren G; Cardiovascular Research Center, Brown University, Providence, USA., Zehender M; Department of Cardiology, University Heart Center, University Hospital Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany., Brunner M; Department of Cardiology, University Heart Center, University Hospital Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.; Department of Cardiology and Intensive Care, St. Josefskrankenhaus Freiburg, Freiburg, Germany., Casoni D; Experimental Surgical Facility, Experimental Animal Center, University of Bern, Bern, Switzerland., Praz F; Department of Cardiology, University Hospital Bern, University of Bern, Bern, Switzerland., Haeberlin A; Department of Cardiology, University Hospital Bern, University of Bern, Bern, Switzerland., Brooks G; Formerly from the Rare Disease Research Unit, Pfizer Inc., Cambridge, MA, USA., Ackerman MJ; Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics, Divisions of Heart Rhythm Services and Pediatric Cardiology, Windland Smith Rice Genetic Heart Rhythm Clinic and The Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Guggenheim 501, Rochester, MN 55905, USA., Odening KE; Translational Cardiology, Department of Cardiology and Department of Physiology, University Hospital Bern, University of Bern, Bühlplatz 5, 3012 Bern, Switzerland.; Department of Cardiology, University Heart Center, University Hospital Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.

Publikováno v: European heart journal [Eur Heart J] 2024 Sep 29; Vol. 45 (36), pp. 3751-3763.

Generation of induced pluripotent stem cell lines from patients with LQT1 caused by heterozygous mutations in the KCNQ1 gene.

Autor: Ren L; Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Depart of Medicine, Division of Cardiovascular Medicine, Stanford, CA 94305, USA., Jahng JWS; Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Depart of Medicine, Division of Cardiovascular Medicine, Stanford, CA 94305, USA., Belbachir N; Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Depart of Medicine, Division of Cardiovascular Medicine, Stanford, CA 94305, USA., Cook Z; Greenstone Biosciences, Palo Alto, CA 94304, USA., Rivero GC; Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Depart of Medicine, Division of Cardiovascular Medicine, Stanford, CA 94305, USA., Perez MV; Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Depart of Medicine, Division of Cardiovascular Medicine, Stanford, CA 94305, USA., Wu JC; Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Depart of Medicine, Division of Cardiovascular Medicine, Stanford, CA 94305, USA. Electronic address: joewu@stanford.edu.

Publikováno v: Stem cell research [Stem Cell Res] 2024 Aug; Vol. 78, pp. 103443. Date of Electronic Publication: 2024 May 16.