Zobrazeno 1 - 10
of 198
pro vyhledávání: '"KCNK3"'
Autor:
Felix Wiedmann, Manuel Kraft, Stefan Kallenberger, Antonius Büscher, Amelie Paasche, Pablo L. Blochberger, Timon Seeger, Natasa Jávorszky, Gregor Warnecke, Rawa Arif, Jamila Kremer, Matthias Karck, Norbert Frey, Constanze Schmidt
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 7 (2022)
Background Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. However, underlying molecular mechanisms are insufficiently understood. Previous studies suggested that microRNA (miRNA) dependent gene regulation plays an important
Externí odkaz:
https://doaj.org/article/9ddec92a514b466baa28b501ea914138
Publikováno v:
Frontiers in Surgery, Vol 9 (2022)
BackgroundProstate cancer (PCa) is one of the most popular cancer types in men. Nevertheless, the pathogenic mechanisms of PCa are poorly understood. Hence, we aimed to identify the potential genetic biomarker of PCa in the present study.MethodsHigh-
Externí odkaz:
https://doaj.org/article/ebc570c797dd4ac9b7c84513f72f5552
Autor:
Hélène Le Ribeuz, Audrey Courboulin, Maria-Rosa Ghigna, Mélanie Lambert, Aurélie Hautefort, Marc Humbert, David Montani, Sylvia Cohen-Kaminsky, Frédéric Perros, Fabrice Antigny
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background The pathogenesis of pulmonary arterial hypertension (PAH) involves many signalling pathways. MicroRNAs are potential candidates involved in simultaneously coordinating multiple genes under such multifactorial conditions. Methods a
Externí odkaz:
https://doaj.org/article/26a236ccb97f44b9b8de19f4f935ba23
Autor:
Zheng-Yong Wen, Chuan-Jie Qin, Yun-Yun Lv, Yan-Ping Li, Yuan-Chao Zou, Sheng-Tao Guo, Qiong Shi
Publikováno v:
Frontiers in Marine Science, Vol 8 (2021)
Potassium channels are important for K+ transport and cell volume regulation, which play important roles in many biological processes such as hormone secretion, ion homeostasis, excitability, and cell development. In mammals, a total of 15 potassium
Externí odkaz:
https://doaj.org/article/ea2095dfa3fe4672a14f9c08fd273cda
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1341 (2022)
Pulmonary arterial hypertension (PAH) is a devastating disease with high morbidity and mortality. Deleterious remodeling in the pulmonary arterial system leads to irreversible arterial constriction and elevated pulmonary arterial pressures, right hea
Externí odkaz:
https://doaj.org/article/6d3c1f4ca390417098685e0b3f9e7c09
Autor:
Benoît Chevalier, Nesrine Baatallah, Matthieu Najm, Solène Castanier, Vincent Jung, Iwona Pranke, Anita Golec, Véronique Stoven, Stefano Marullo, Fabrice Antigny, Ida Chiara Guerrera, Isabelle Sermet-Gaudelus, Aleksander Edelman, Alexandre Hinzpeter
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8937 (2022)
Proteins interacting with CFTR and its mutants have been intensively studied using different experimental approaches. These studies provided information on the cellular processes leading to proper protein folding, routing to the plasma membrane, recy
Externí odkaz:
https://doaj.org/article/76ec2236d3bc421abf870a741f154d49
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/12334bbba9494f8a9da4c5d79556adec
Autor:
Manuel Kraft, Antonius Büscher, Felix Wiedmann, Yannick L’hoste, Walter E. Haefeli, Norbert Frey, Hugo A. Katus, Constanze Schmidt
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Atrial fibrillation (AF) is the most common sustained arrhythmia with a prevalence of up to 4% and an upwards trend due to demographic changes. It is associated with an increase in mortality and stroke incidences. While stroke risk can be significant
Externí odkaz:
https://doaj.org/article/f3fc694076744efe853c265b4efa84c3
Autor:
Felix Wiedmann, Christoph Beyersdorf, Xiao-Bo Zhou, Manuel Kraft, Kathrin I. Foerster, Ibrahim El-Battrawy, Siegfried Lang, Martin Borggrefe, Walter E. Haefeli, Norbert Frey, Constanze Schmidt
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
BackgroundUpregulation of the two-pore-domain potassium channel TASK-1 (hK2P3.1) was recently described in patients suffering from atrial fibrillation (AF) and resulted in shortening of the atrial action potential. In the human heart, TASK-1 channels
Externí odkaz:
https://doaj.org/article/54eddb22db5b4324b5ea8376b0a17eda
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and one of the major causes of cardiovascular morbidity and mortality. Despite good progress within the past years, safe and effective treatment of AF remains an unm
Externí odkaz:
https://doaj.org/article/728ba1137c604984b26cc010f8077558