Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision.

Autor: Sachdev A; Gladstone Institutes, San Francisco, CA 94158., Gill K; Gladstone Institutes, San Francisco, CA 94158.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158., Sckaff M; Gladstone Institutes, San Francisco, CA 94158.; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158., Birk AM; Gladstone Institutes, San Francisco, CA 94158., Aladesuyi Arogundade O; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.; Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158., Brown KA; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.; Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158., Chouhan RS; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.; Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158., Issagholian-Lewin PO; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.; Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158., Patel E; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.; Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158., Watry HL; Gladstone Institutes, San Francisco, CA 94158., Bernardi MT; Gladstone Institutes, San Francisco, CA 94158., Keough KC; Gladstone Institutes, San Francisco, CA 94158., Tsai YC; Pacific Biosciences, Menlo Park, CA 94025., Smith AST; Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195.; The Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195., Conklin BR; Gladstone Institutes, San Francisco, CA 94158.; Department of Medicine, University of California San Francisco, San Francisco, CA 94143.; Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143.; Department of Pharmacology, University of California San Francisco, San Francisco, CA 94158., Clelland CD; Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94158.; Memory & Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA 94158.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Apr 23; Vol. 121 (17), pp. e2307814121. Date of Electronic Publication: 2024 Apr 15.

Evolutionary constraint and innovation across hundreds of placental mammals.

Autor: Christmas MJ; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 32 Uppsala, Sweden., Kaplow IM; Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA., Genereux DP; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Dong MX; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 32 Uppsala, Sweden., Hughes GM; School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland., Li X; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.; Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA 01605, USA.; Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01605, USA., Sullivan PF; Department of Genetics, University of North Carolina Medical School, Chapel Hill, NC 27599, USA.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Hindle AG; School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA., Andrews G; Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01605, USA., Armstrong JC; Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Bianchi M; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 32 Uppsala, Sweden., Breit AM; School of Biology and Ecology, University of Maine, Orono, ME 04469, USA., Diekhans M; Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Fanter C; School of Life Sciences, University of Nevada Las Vegas, Las Vegas, NV 89154, USA., Foley NM; Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA., Goodman DB; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Goodman L; Fauna Bio, Inc., Emeryville, CA 94608, USA., Keough KC; Fauna Bio, Inc., Emeryville, CA 94608, USA.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA.; Gladstone Institutes, San Francisco, CA 94158, USA., Kirilenko B; Faculty of Biosciences, Goethe-University, 60438 Frankfurt, Germany.; LOEWE Centre for Translational Biodiversity Genomics, 60325 Frankfurt, Germany.; Senckenberg Research Institute, 60325 Frankfurt, Germany., Kowalczyk A; Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA., Lawless C; School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland., Lind AL; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA.; Gladstone Institutes, San Francisco, CA 94158, USA., Meadows JRS; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 32 Uppsala, Sweden., Moreira LR; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.; Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01605, USA., Redlich RW; Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA., Ryan L; School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland., Swofford R; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Valenzuela A; Department of Experimental and Health Sciences, Institute of Evolutionary Biology (UPF-CSIC), Universitat Pompeu Fabra, 08003 Barcelona, Spain., Wagner F; Museum of Zoology, Senckenberg Natural History Collections Dresden, 01109 Dresden, Germany., Wallerman O; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 32 Uppsala, Sweden., Brown AR; Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA., Damas J; The Genome Center, University of California Davis, Davis, CA 95616, USA., Fan K; Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01605, USA., Gatesy J; Division of Vertebrate Zoology, American Museum of Natural History, New York, NY 10024, USA., Grimshaw J; Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA., Johnson J; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Kozyrev SV; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 32 Uppsala, Sweden., Lawler AJ; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.; Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA., Marinescu VD; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 32 Uppsala, Sweden., Morrill KM; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.; Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA 01605, USA.; Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01605, USA., Osmanski A; Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Paulat NS; Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA., Phan BN; Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Reilly SK; Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA., Schäffer DE; Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA., Steiner C; Conservation Genetics, San Diego Zoo Wildlife Alliance, Escondido, CA 92027, USA., Supple MA; Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Wilder AP; Conservation Genetics, San Diego Zoo Wildlife Alliance, Escondido, CA 92027, USA., Wirthlin ME; Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Allen Institute for Brain Science, Seattle, WA 98109, USA., Xue JR; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Birren BW; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Gazal S; Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Hubley RM; Institute for Systems Biology, Seattle, WA 98109, USA., Koepfli KP; Center for Species Survival, Smithsonian's National Zoo and Conservation Biology Institute, Washington, DC 20008, USA.; Computer Technologies Laboratory, ITMO University, St. Petersburg 197101, Russia.; Smithsonian-Mason School of Conservation, George Mason University, Front Royal, VA 22630, USA., Marques-Bonet T; Catalan Institution of Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), 08036 Barcelona, Spain.; Department of Medicine and Life Sciences, Institute of Evolutionary Biology (UPF-CSIC), Universitat Pompeu Fabra, 08003 Barcelona, Spain.; Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain., Meyer WK; Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA., Nweeia M; Department of Comprehensive Care, School of Dental Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.; Department of Vertebrate Zoology, Canadian Museum of Nature, Ottawa, Ontario K2P 2R1, Canada.; Department of Vertebrate Zoology, Smithsonian Institution, Washington, DC 20002, USA.; Narwhal Genome Initiative, Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA 02115, USA., Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA., Shapiro B; Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.; Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Smit AFA; Institute for Systems Biology, Seattle, WA 98109, USA., Springer MS; Department of Evolution, Ecology and Organismal Biology, University of California Riverside, Riverside, CA 92521, USA., Teeling EC; School of Biology and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland., Weng Z; Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01605, USA., Hiller M; Faculty of Biosciences, Goethe-University, 60438 Frankfurt, Germany.; LOEWE Centre for Translational Biodiversity Genomics, 60325 Frankfurt, Germany.; Senckenberg Research Institute, 60325 Frankfurt, Germany., Levesque DL; School of Biology and Ecology, University of Maine, Orono, ME 04469, USA., Lewin HA; The Genome Center, University of California Davis, Davis, CA 95616, USA.; Department of Evolution and Ecology, University of California Davis, Davis, CA 95616, USA.; John Muir Institute for the Environment, University of California Davis, Davis, CA 95616, USA., Murphy WJ; Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843, USA., Navarro A; Catalan Institution of Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.; Department of Medicine and Life Sciences, Institute of Evolutionary Biology (UPF-CSIC), Universitat Pompeu Fabra, 08003 Barcelona, Spain.; BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, 08005 Barcelona, Spain.; CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), 08003 Barcelona, Spain., Paten B; Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA., Pollard KS; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA.; Gladstone Institutes, San Francisco, CA 94158, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Ray DA; Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA., Ruf I; Division of Messel Research and Mammalogy, Senckenberg Research Institute and Natural History Museum Frankfurt, 60325 Frankfurt am Main, Germany., Ryder OA; Conservation Genetics, San Diego Zoo Wildlife Alliance, Escondido, CA 92027, USA.; Department of Evolution, Behavior and Ecology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92039, USA., Pfenning AR; Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.; Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA., Lindblad-Toh K; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, 751 32 Uppsala, Sweden.; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Karlsson EK; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.; Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA 01605, USA.; Program in Molecular Medicine, UMass Chan Medical School, Worcester, MA 01605, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Apr 28; Vol. 380 (6643), pp. eabn3943. Date of Electronic Publication: 2023 Apr 28.

Three-dimensional genome rewiring in loci with human accelerated regions.

Autor: Keough KC; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA., Whalen S; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA., Inoue F; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA., Przytycki PF; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA., Fair T; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA., Deng C; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA., Steyert M; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA., Ryu H; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA., Lindblad-Toh K; Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Karlsson E; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Bioinformatics and Integrative Biology, UMass Chan Medical School, Worcester, MA, USA.; Program in Molecular Medicine, UMass Chan Medical School, Worcester, MA, USA., Nowakowski T; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA., Ahituv N; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA., Pollen A; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Pollard KS; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.; Department of Epidemiology & Biostatistics and Bakar Institute for Computational Health Sciences, University of California San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Apr 28; Vol. 380 (6643), pp. eabm1696. Date of Electronic Publication: 2023 Apr 28.

Bi-allelic CAMSAP1 variants cause a clinically recognizable neuronal migration disorder.

Autor: Khalaf-Nazzal R; Biomedical Sciences Department, Faculty of Medicine, Arab American University of Palestine, Jenin P227, Palestine., Fasham J; Department of Clinical and Biomedical Science, University of Exeter Faculty of Health and Life Science, RILD building, Barrack Road, Exeter EX2 5DW, UK; Peninsula Clinical Genetics Service, Royal Devon University Healthcare NHS Foundation Trust (Heavitree Hospital), Gladstone Road, Exeter EX1 2ED, UK., Inskeep KA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7016, Cincinnati, OH 45229, USA; Institute for Genomic Medicine at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH 43205, USA., Blizzard LE; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7016, Cincinnati, OH 45229, USA., Leslie JS; Department of Clinical and Biomedical Science, University of Exeter Faculty of Health and Life Science, RILD building, Barrack Road, Exeter EX2 5DW, UK., Wakeling MN; Department of Clinical and Biomedical Science, University of Exeter Faculty of Health and Life Science, RILD building, Barrack Road, Exeter EX2 5DW, UK., Ubeyratna N; Department of Clinical and Biomedical Science, University of Exeter Faculty of Health and Life Science, RILD building, Barrack Road, Exeter EX2 5DW, UK., Mitani T; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Griffith JL; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Baker W; Paediatrics Department, Dr. Khalil Suleiman Government Hospital, Jenin, Palestine., Al-Hijawi F; Paediatrics Community Outpatient Clinics, Palestinian Ministry of Health, Jenin, Palestine., Keough KC; Department of Pediatrics, Dell Medical School, 1400 Barbara Jordan Boulevard, Austin, TX 78723, USA; Child Neurology Consultants of Austin, 7940 Shoal Creek Boulevard, Suite 100, Austin, TX 78757, USA., Gezdirici A; Department of Medical Genetics, Başakşehir Çam and Sakura City Hospital, 34480 Istanbul, Turkey., Pena L; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7016, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Spaeth CG; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7016, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Turnpenny PD; Department of Clinical and Biomedical Science, University of Exeter Faculty of Health and Life Science, RILD building, Barrack Road, Exeter EX2 5DW, UK; Peninsula Clinical Genetics Service, Royal Devon University Healthcare NHS Foundation Trust (Heavitree Hospital), Gladstone Road, Exeter EX1 2ED, UK., Walsh JR; Department of Neurological Surgery, School of Medicine, Washington University in Saint Louis, St. Louis, MO 63110, USA., Ray R; Departments of Pediatrics and Medical Genetics, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA., Neilson A; Genome Engineering & Stem Cell Center, Department of Genetics, School of Medicine, Washington University in Saint Louis, St. Louis, MO 63110, USA., Kouranova E; Genome Engineering & Stem Cell Center, Department of Genetics, School of Medicine, Washington University in Saint Louis, St. Louis, MO 63110, USA., Cui X; Genome Engineering & Stem Cell Center, Department of Genetics, School of Medicine, Washington University in Saint Louis, St. Louis, MO 63110, USA., Curiel DT; Department of Biomedical Engineering, McKelvey School of Engineering, Washington University in Saint Louis, St. Louis, MO 63130, USA; Division of Cancer Biology, Department of Radiation Oncology, School of Medicine, Washington University in Saint Louis, St. Louis, MO 63110, USA; Biologic Therapeutics Center, Department of Radiation Oncology, School of Medicine, Washington University in Saint Louis, St. Louis, MO 63110, USA., Pehlivan D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Division of Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA., Akdemir ZC; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Posey JE; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Lupski JR; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030, USA., Dobyns WB; Departments of Pediatrics and Genetics, University of Minnesota, Minneapolis, MN, USA., Stottmann RW; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7016, Cincinnati, OH 45229, USA; Institute for Genomic Medicine at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH 43205, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7016, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA., Crosby AH; Department of Clinical and Biomedical Science, University of Exeter Faculty of Health and Life Science, RILD building, Barrack Road, Exeter EX2 5DW, UK., Baple EL; Department of Clinical and Biomedical Science, University of Exeter Faculty of Health and Life Science, RILD building, Barrack Road, Exeter EX2 5DW, UK; Peninsula Clinical Genetics Service, Royal Devon University Healthcare NHS Foundation Trust (Heavitree Hospital), Gladstone Road, Exeter EX1 2ED, UK. Electronic address: e.baple@exeter.ac.uk.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2022 Nov 03; Vol. 109 (11), pp. 2068-2079. Date of Electronic Publication: 2022 Oct 24.

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

Autor: Gordon DE; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Hiatt J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Medical Scientist Training Program, University of California, San Francisco, CA 94143, USA.; Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143, USA., Bouhaddou M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Rezelj VV; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France., Ulferts S; Institute for Clinical and Experimental Pharmacology and Toxicology I, University of Freiburg, 79104 Freiburg, Germany., Braberg H; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Jureka AS; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA., Obernier K; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Guo JZ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Batra J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Kaake RM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Weckstein AR; Aetion, Inc., New York, NY 10001, USA., Owens TW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Gupta M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Pourmal S; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Titus EW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Cakir M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Soucheray M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., McGregor M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Cakir Z; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Jang G; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., O'Meara MJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Tummino TA; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Zhang Z; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., Foussard H; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Rojc A; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Zhou Y; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Kuchenov D; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Hüttenhain R; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Xu J; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Eckhardt M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. 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David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Medicine, University of California, San Francisco, CA 94143, USA., Palmarini M; MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, Scotland, UK., Shokat KM; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; 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Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.; Department of Medicine, University of California, San Francisco, CA 94143, USA., Verba KA; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Basler CF; Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Vignuzzi M; Viral Populations and Pathogenesis Unit, CNRS UMR 3569, Institut Pasteur, 75724, Paris, cedex 15, France. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Peden AA; Department of Biomedical Science, Centre for Membrane Interactions and Dynamics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Beltrao P; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu., Krogan NJ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA. nevan.krogan@ucsf.edu pbeltrao@ebi.ac.uk marco.vignuzzi@pasteur.fr cbasler@gsu.edu verba@msg.ucsf.edu oren.rosenberg@ucsf.edu a.peden@sheffield.ac.uk robert.grosse@pharmakol.uni-freiburg.de jeremy.rassen@aetion.com Adolfo.Garcia-Sastre@mssm.edu.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Dec 04; Vol. 370 (6521). Date of Electronic Publication: 2020 Oct 15.