Zobrazeno 1 - 10
of 454
pro vyhledávání: '"KAZUHIKO TAKEHARA"'
Autor:
Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, Masanari Kodera, Yuichiro Shirai, Mitsuteru Akahoshi, Minoru Hasegawa, Takashi Matsushita, Kazuyoshi Saito, Sei-ichiro Motegi, Hajime Yoshifuji, Ayumi Yoshizaki, Tomohiro Kohmoto, Kae Takagi, Akira Oka, Miho Kanda, Yoshihito Tanaka, Yumi Ito, Kazuhisa Nakano, Hiroshi Kasamatsu, Akira Utsunomiya, Akiko Sekiguchi, Hiroaki Niiro, Masatoshi Jinnin, Katsunari Makino, Takamitsu Makino, Hironobu Ihn, Motohisa Yamamoto, Chisako Suzuki, Hiroki Takahashi, Emi Nishida, Akimichi Morita, Toshiyuki Yamamoto, Manabu Fujimoto, Yuya Kondo, Daisuke Goto, Takayuki Sumida, Naho Ayuzawa, Hidetoshi Yanagida, Tetsuya Horita, Tatsuya Atsumi, Hirahito Endo, Yoshihito Shima, Atsushi Kumanogoh, Jun Hirata, Nao Otomo, Hiroyuki Suetsugu, Yoshinao Koike, Kohei Tomizuka, Soichiro Yoshino, Xiaoxi Liu, Shuji Ito, Keiko Hikino, Akari Suzuki, Yukihide Momozawa, Shiro Ikegawa, Yoshiya Tanaka, Osamu Ishikawa, Kazuhiko Takehara, Takeshi Torii, Shinichi Sato, Yukinori Okada, Tsuneyo Mimori, Fumihiko Matsuda, Koichi Matsuda, Tiffany Amariuta, Issei Imoto, Keitaro Matsuo, Masataka Kuwana, Yasushi Kawaguchi, Koichiro Ohmura, Chikashi Terao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region,
Externí odkaz:
https://doaj.org/article/2821292baef747248e9e487cef06ad07
Autor:
Kazuhiro Komura, Koichi Yanaba, Jean-David Bouaziz, Ayumi Yoshizaki, Minoru Hasegawa, John Varga, Kazuhiko Takehara, Takashi Matsushita
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Systemic sclerosis (SSc) is a rare and heterogeneous disease with no relevant environmental trigger or significant responsible gene. It has been and will continue to be difficult to identify large enough patients to conduct classic population-based e
Externí odkaz:
https://doaj.org/article/07b028307791424786e4efb7380fc3c6
Autor:
Kyosuke Oishi, Kyoko Shimizu, Kouhei Takehara, Shintaro Maeda, Takashi Matsushita, Toru Yukami, Kazuhiko Takehara, Yasuhito Hamaguchi
Publikováno v:
Journal of Cutaneous Immunology and Allergy, Vol 4, Iss 1, Pp 13-16 (2021)
Abstract An 83‐year‐old man with muscle involvement and interstitial lung disease (ILD) was diagnosed with anti‐OJ antibody (Ab)‐positive polymyositis (PM). He did not have Raynaud's phenomenon, heliotrope rash, Gottron's sign, fever, arthral
Externí odkaz:
https://doaj.org/article/482e60e7cb57482f9c5363265f5b3ace
Autor:
Kaori Sawada, Tomoyo Sawada, Tadahiro Kobayashi, Akiko Fujiki, Takashi Matsushita, Shigeru Kawara, Kentaro Izumi, Wataru Nishie, Hiroshi Shimizu, Kazuhiko Takehara, Yasuhito Hamaguchi
Publikováno v:
Immunological Medicine, Vol 44, Iss 1, Pp 53-55 (2021)
Bullous pemphigoid (BP) is a cutaneous autoimmune blistering disorder. Recently, it has been reported that dipeptidyl peptidase-4 inhibitors (DPP4i) is associated with the development of BP (DPP4i-BP). Patients with DPP4i-BP have autoantibodies (auto
Externí odkaz:
https://doaj.org/article/188aacc15f304d18a8c4ef9f1d2b69f1
Autor:
Naoki Mugii, Minoru Hasegawa, Takashi Matsushita, Yasuhito Hamaguchi, Sacihe Oohata, Hirokazu Okita, Tetsutarou Yahata, Fujiko Someya, Katsumi Inoue, Shigeyuki Murono, Manabu Fujimoto, Kazuhiko Takehara
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154746 (2016)
OBJECTIVE:Dysphagia develops with low frequency in patients with dermatomyositis. Our objective was to determine the clinical and laboratory features that can estimate the development of dysphagia in dermatomyositis. METHODS:This study included 92 Ja
Externí odkaz:
https://doaj.org/article/67c7e88e53f543128b08008e75bcadb6
Autor:
Hiroshi Furukawa, Shomi Oka, Aya Kawasaki, Kota Shimada, Shoji Sugii, Takashi Matsushita, Atsushi Hashimoto, Akiko Komiya, Naoshi Fukui, Kouji Kobayashi, Atsumu Osada, Atsushi Ihata, Yuya Kondo, Tatsuo Nagai, Keigo Setoguchi, Akiko Okamoto, Akira Okamoto, Noriyuki Chiba, Eiichi Suematsu, Hajime Kono, Masao Katayama, Shunsei Hirohata, Takayuki Sumida, Kiyoshi Migita, Minoru Hasegawa, Manabu Fujimoto, Shinichi Sato, Shouhei Nagaoka, Kazuhiko Takehara, Shigeto Tohma, Naoyuki Tsuchiya
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154255 (2016)
Several studies on associations between human leukocyte antigen (HLA) allele frequencies and susceptibility to systemic sclerosis (SSc) have been reported. Anti-centromere antibodies (ACA) and anti-topoisomerase I antibodies (ATA) are found in SSc pa
Externí odkaz:
https://doaj.org/article/420033d6607340dfbf100fabe0b10284
Autor:
Shinji Sato, Akihiro Murakami, Akiko Kuwajima, Kazuhiko Takehara, Tsuneyo Mimori, Atsushi Kawakami, Michiaki Mishima, Takafumi Suda, Mariko Seishima, Manabu Fujimoto, Masataka Kuwana
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154285 (2016)
Autoantibodies to melanoma differentiation-associated gene 5 (MDA5) are specifically expressed in patients with dermatomyositis (DM) and are associated with a subset of DM patients with rapidly progressive interstitial lung disease (RP-ILD). Here, we
Externí odkaz:
https://doaj.org/article/fc8ff9d48a2a49248b7cc39826c925ed
Autor:
Minoru Hasegawa, Yoshihide Asano, Hirahito Endo, Manabu Fujimoto, Daisuke Goto, Hironobu Ihn, Katsumi Inoue, Osamu Ishikawa, Yasushi Kawaguchi, Masataka Kuwana, Fumihide Ogawa, Hiroki Takahashi, Sumiaki Tanaka, Shinichi Sato, Kazuhiko Takehara
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88150 (2014)
OBJECTIVE: To assess the utility of circulating adhesion molecule levels as a prognostic indicator of disease progression in systemic sclerosis (SSc) patients with early onset disease. METHODS: Ninety-two Japanese patients with early onset SSc presen
Externí odkaz:
https://doaj.org/article/efb00b1987674d529350fb02fc1f72c2
Autor:
Yasuhito Hamaguchi, Manabu Fujimoto, Takashi Matsushita, Kenzo Kaji, Kazuhiro Komura, Minoru Hasegawa, Masanari Kodera, Eiji Muroi, Keita Fujikawa, Mariko Seishima, Hidehiro Yamada, Ryo Yamada, Shinichi Sato, Kazuhiko Takehara, Masataka Kuwana
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60442 (2013)
OBJECTIVE: To identify similarities and differences in the clinical features of adult Japanese patients with individual anti-aminoacyl-tRNA synthetase antibodies (anti-ARS Abs). METHODS: This was a retrospective analysis of 166 adult Japanese patient
Externí odkaz:
https://doaj.org/article/3cd8edbd75bb4012afe2ceb46178f2a4
Autor:
Swati Bhattacharyya, Jennifer L Sargent, Pan Du, Simon Lin, Warren G Tourtellotte, Kazuhiko Takehara, Michael L Whitfield, John Varga
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23082 (2011)
Transforming growth factor-ß (TGF-ß) signaling is implicated in the pathogenesis of fibrosis in scleroderma or systemic sclerosis (SSc), but the precise mechanisms are poorly understood. The immediate-early gene Egr-1 is an inducible transcription
Externí odkaz:
https://doaj.org/article/69140d2364294017bf50e98e9ca86f9b