Zobrazeno 1 - 10
of 638
pro vyhledávání: '"KAZUHIKO TAKEHARA"'
Autor:
Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, Masanari Kodera, Yuichiro Shirai, Mitsuteru Akahoshi, Minoru Hasegawa, Takashi Matsushita, Kazuyoshi Saito, Sei-ichiro Motegi, Hajime Yoshifuji, Ayumi Yoshizaki, Tomohiro Kohmoto, Kae Takagi, Akira Oka, Miho Kanda, Yoshihito Tanaka, Yumi Ito, Kazuhisa Nakano, Hiroshi Kasamatsu, Akira Utsunomiya, Akiko Sekiguchi, Hiroaki Niiro, Masatoshi Jinnin, Katsunari Makino, Takamitsu Makino, Hironobu Ihn, Motohisa Yamamoto, Chisako Suzuki, Hiroki Takahashi, Emi Nishida, Akimichi Morita, Toshiyuki Yamamoto, Manabu Fujimoto, Yuya Kondo, Daisuke Goto, Takayuki Sumida, Naho Ayuzawa, Hidetoshi Yanagida, Tetsuya Horita, Tatsuya Atsumi, Hirahito Endo, Yoshihito Shima, Atsushi Kumanogoh, Jun Hirata, Nao Otomo, Hiroyuki Suetsugu, Yoshinao Koike, Kohei Tomizuka, Soichiro Yoshino, Xiaoxi Liu, Shuji Ito, Keiko Hikino, Akari Suzuki, Yukihide Momozawa, Shiro Ikegawa, Yoshiya Tanaka, Osamu Ishikawa, Kazuhiko Takehara, Takeshi Torii, Shinichi Sato, Yukinori Okada, Tsuneyo Mimori, Fumihiko Matsuda, Koichi Matsuda, Tiffany Amariuta, Issei Imoto, Keitaro Matsuo, Masataka Kuwana, Yasushi Kawaguchi, Koichiro Ohmura, Chikashi Terao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Here we report the largest Asian genome-wide association study (GWAS) for systemic sclerosis performed to date, based on data from Japanese subjects and comprising of 1428 cases and 112,599 controls. The lead SNP is in the FCGR/FCRL region,
Externí odkaz:
https://doaj.org/article/2821292baef747248e9e487cef06ad07
Autor:
Kazuhiro Komura, Koichi Yanaba, Jean-David Bouaziz, Ayumi Yoshizaki, Minoru Hasegawa, John Varga, Kazuhiko Takehara, Takashi Matsushita
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Systemic sclerosis (SSc) is a rare and heterogeneous disease with no relevant environmental trigger or significant responsible gene. It has been and will continue to be difficult to identify large enough patients to conduct classic population-based e
Externí odkaz:
https://doaj.org/article/07b028307791424786e4efb7380fc3c6
Autor:
Kyosuke Oishi, Kyoko Shimizu, Kouhei Takehara, Shintaro Maeda, Takashi Matsushita, Toru Yukami, Kazuhiko Takehara, Yasuhito Hamaguchi
Publikováno v:
Journal of Cutaneous Immunology and Allergy, Vol 4, Iss 1, Pp 13-16 (2021)
Abstract An 83‐year‐old man with muscle involvement and interstitial lung disease (ILD) was diagnosed with anti‐OJ antibody (Ab)‐positive polymyositis (PM). He did not have Raynaud's phenomenon, heliotrope rash, Gottron's sign, fever, arthral
Externí odkaz:
https://doaj.org/article/482e60e7cb57482f9c5363265f5b3ace
Autor:
Kaori Sawada, Tomoyo Sawada, Tadahiro Kobayashi, Akiko Fujiki, Takashi Matsushita, Shigeru Kawara, Kentaro Izumi, Wataru Nishie, Hiroshi Shimizu, Kazuhiko Takehara, Yasuhito Hamaguchi
Publikováno v:
Immunological Medicine, Vol 44, Iss 1, Pp 53-55 (2021)
Bullous pemphigoid (BP) is a cutaneous autoimmune blistering disorder. Recently, it has been reported that dipeptidyl peptidase-4 inhibitors (DPP4i) is associated with the development of BP (DPP4i-BP). Patients with DPP4i-BP have autoantibodies (auto
Externí odkaz:
https://doaj.org/article/188aacc15f304d18a8c4ef9f1d2b69f1
Autor:
Yuki Ishikawa, Nao Tanaka, Yoshihide Asano, Masanari Kodera, Yuichiro Shirai, Mitsuteru Akahoshi, Minoru Hasegawa, Takashi Matsushita, Kazuyoshi Saito, Sei-ishiro Motegi, Hajime Yoshifuji, Ayumi Yoshizaki, Tomohiro Komoto, Kae Takagi, Akira Oka, Miho Kanda, Yoshihito Tanak, Yumi Ito, Kazuhisa Nakano, Hiroshi Kasamatsu, Akira Utsunomiya, Akiko Sekiguchi, Hiroaki Niro, Masatoshi Jinnin, Katsunari Makino, Takamitsu Makino, Hironobu Ihn, Motohisa Yamamoto, Chisako Suzuki, Hiroki Takahashi, Emi Nishida, Akimichi Morita, Toshiyuki Yamamoto, Manabu Fujimoto, Yuya Kondo, Daisuke Goto, Takayuki Sumida, Naho Ayuzawa, Hidetashi Yanagida, Tetsuya Horita, Tatsuya Atsumi, Hirahito Endo, Yoshihito Shima, Atsushi Kumanogoh, Jun Hirata, Nao Otomo, Hiroyuki Suetsugu, Yoshinao Koike, Kohei Tomizuka, Soichiro Yoshino, Xiaoxi Liu, Shuji Ito, Keiko Hikino, Akari Suzuki, Yukihide Momozawa, Shiro Ikegawa, Yoshiya Tanaka, Osamu Ishikawa, Kazuhiko Takehara, Takeshi Torii, Shinichi Sato, Yukinori Okada, Tsuneyo Mimori, Fumihiko Matsuda, Koichi Matsuda, Tiffany Amariuta, Issei Imoto, Keitaro Matsuo, Masataka Kuwana, Yasushi Kawaguchi, Koichiro Ohmura, Chikashi Terao
We conducted a Japanese GWAS for systemic sclerosis (SSc) comprising 1,428 cases and 112,599 controls, the largest Asian GWAS for SSc ever, and identified three novel signals. The lead SNP in FCGR/FCRL region had a strong effect size (OR 2.05, P = 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c211a504e6abe4bb4b7e51e21895eaa5
https://doi.org/10.21203/rs.3.rs-2712663/v1
https://doi.org/10.21203/rs.3.rs-2712663/v1
Autor:
Akito Komuro, Kazuhiko Takehara, Kyosuke Oishi, Yuka Ikawa, Shintaro Maeda, Kaori Sawada, Yasuhito Hamaguchi, Takashi Matsushita, Kie Mizumaki
Publikováno v:
Journal of Dermatological Science. 104:201-209
Background Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by excessive fibrosis. FcγRIIB is a low-affinity receptor for the Fc fragment of IgG. FcγRIIB is expressed on the surface of various leukocyte subsets and signals ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf5f5958022e867d199be692fd07d0f
https://doi.org/10.1016/j.jdermsci.2021.11.002
https://doi.org/10.1016/j.jdermsci.2021.11.002
Autor:
Takashi Matsushita, Kazuhiko Takehara, Akito Komuro, Yuka Ikawa, Shintaro Maeda, Kyosuke Oishi, Kie Mizumaki, Natsuki Numata, Yasuhito Hamaguchi, Kaori Sawada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a49288d515fb19d0bae8db123a4447
https://doi.org/10.26226/m.62fa008e5b695e001a54207b
https://doi.org/10.26226/m.62fa008e5b695e001a54207b
Autor:
Michiaki Mishima, Akihiro Murakami, Tsuneyo Mimori, Mariko Seishima, Kazuhiko Takehara, Atsushi Kawakami, Shinji Sato, Takafumi Suda, Manabu Fujimoto, Ikuko Ueda-Hayakawa, Masataka Kuwana
Publikováno v:
Journal of Dermatological Science. 103:53-56
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::181b6643b5b6af8f1bc33bddf6475e32
https://doi.org/10.1016/j.jdermsci.2021.05.005
https://doi.org/10.1016/j.jdermsci.2021.05.005
Autor:
K. Takehara, Kyoko Shimizu, Shintaro Maeda, Kazuhiko Takehara, Kyosuke Oishi, Yasuhito Hamaguchi, Takashi Matsushita, Toru Yukami
Publikováno v:
Journal of Cutaneous Immunology and Allergy, Vol 4, Iss 1, Pp 13-16 (2021)
An 83‐year‐old man with muscle involvement and interstitial lung disease (ILD) was diagnosed with anti‐OJ antibody (Ab)‐positive polymyositis (PM). He did not have Raynaud's phenomenon, heliotrope rash, Gottron's sign, fever, arthralgia, or m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef89aee2fff0b3e802e386b21094445e
https://doi.org/10.1002/cia2.12152
https://doi.org/10.1002/cia2.12152
Publikováno v:
The Journal of Dermatology. 48:106-109
Nail fold videocapillaroscopy (NVC) abnormalities are a characteristic finding of microangiopathy in dermatomyositis (DM). The aim of the present study was to examine long-term changes in NVC abnormalities and serum fibroblast growth factor 23 (FGF23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae2256c468993bf01ea67d2b66ea96b
https://doi.org/10.1111/1346-8138.15589
https://doi.org/10.1111/1346-8138.15589