Výsledky vyhledávání - "KAZUAKI TABU"

Akademický článek

Analysis of the susceptibility of refractory hepatitis C virus resistant to nonstructural 5A inhibitors

Autor: Ai Toyodome, Seiichi Mawatari, Hiromi Eguchi, Midori Takeda, Kotaro Kumagai, Ohki Taniyama, Sho Ijuin, Haruka Sakae, Kazuaki Tabu, Kohei Oda, Masanori Ikeda, Akio Ido

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)

Abstract Resistance-associated substitutions (RASs) of hepatitis C virus (HCV) affect the efficacy of direct-acting antivirals (DAAs). In this study, we aimed to clarify the susceptibility of the coexistence of nonstructural (NS) 5A Q24K/L28M/R30Q (o

Externí odkaz: https://doaj.org/article/3fe6eb0227284a16be2ea8103fd1f582

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Akademický článek

Glycoprotein non-metastatic melanoma protein B expression correlates with the prognosis of acute liver injury/failure

Autor: Kotaro Kumagai, Shuji Kanmura, Seiichi Mawatari, Yuko Nakamura, Hiromi Eguchi, Oki Taniyama, Ai Toyodome, Sho Ijuin, Haruka Sakae, Kazuaki Tabu, Kohei Oda, Keita Shimata, Taizo Hibi, Akio Ido

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Background: Glycoprotein non-metastatic melanoma protein B (GPNMB) is expressed in macrophages during recovery from acute liver injury (ALI) in carbon tetrachloride (CCl4)-induced liver injury model mice. In this retrospective study, we assessed whet

Externí odkaz: https://doaj.org/article/a1f40279821e4041848a49127e33c2db

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Akademický článek

Features of patients who developed hepatocellular carcinoma after direct-acting antiviral treatment for hepatitis C Virus

Publikováno v: PLoS ONE, Vol 17, Iss 1 (2022)

Background The features of hepatitis C virus patients with a sustained virologic response (SVR) who developed hepatocellular carcinoma (HCC) after direct-acting antiviral (DAA) therapy are unclear. Methods The study population included 1494 DAA-SVR p

Externí odkaz: https://doaj.org/article/a9d631c3572b48d2b03ea489655c1018

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Akademický článek

Hypovascular tumors developed into hepatocellular carcinoma at a high rate despite the elimination of hepatitis C virus by direct-acting antivirals.

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237475 (2020)

Background and aimsDirect-acting antivirals (DAAs) against hepatitis C virus (HCV) exert high anti-HCV activity and are expected to show anti-inflammatory effects associated with HCV elimination. Furthermore, hepatocellular carcinoma (HCC) is known t

Externí odkaz: https://doaj.org/article/77e19cc7fd2f44569864b15ba39951ef

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Akademický článek

The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir.

Autor: Seiichi Mawatari, Kohei Oda, Kazuaki Tabu, Sho Ijuin, Kotaro Kumagai, Kunio Fujisaki, Masafumi Hashiguchi, Yukiko Inada, Hirofumi Uto, Yasunari Hiramine, Takeshi Kure, Takeshi Hori, Oki Taniyama, Ai Kasai, Tsutomu Tamai, Akihiro Moriuchi, Akio Ido

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198642 (2018)

OBJECTIVE:The present study aimed to reveal the factors associated with virologic failure in sofosbuvir and ledipasvir (SOF/LDV)-treated patients, and identify baseline NS5A or NS5B resistance-associated substitutions (RASs). METHODS:Four hundred nin

Externí odkaz: https://doaj.org/article/dd5b56e94e8f4b56a63aad408af02b30

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Akademický článek

Human neutrophil peptide-1 promotes alcohol-induced hepatic fibrosis and hepatocyte apoptosis.

Autor: Rie Ibusuki, Hirofumi Uto, Kohei Oda, Akihiko Ohshige, Kazuaki Tabu, Seiichi Mawatari, Kotaro Kumagai, Shuji Kanmura, Tsutomu Tamai, Akihiro Moriuchi, Hirohito Tsubouchi, Akio Ido

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0174913 (2017)

Neutrophil infiltration of the liver is a typical feature of alcoholic liver injury. Human neutrophil peptide (HNP)-1 is an antimicrobial peptide secreted by neutrophils. The aim of this study was to determine if HNP-1 affects ethanol-induced liver i

Externí odkaz: https://doaj.org/article/3fcd7cd994b040e89977b5e26e5b349f

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Akademický článek

Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice.

Autor: Kotaro Kumagai, Kazuaki Tabu, Fumisato Sasaki, Yoichiro Takami, Yuko Morinaga, Seiichi Mawatari, Shinichi Hashimoto, Shiroh Tanoue, Shuji Kanmura, Tsutomu Tamai, Akihiro Moriuchi, Hirofumi Uto, Hirohito Tsubouchi, Akio Ido

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143413 (2015)

Glycoprotein nonmetastatic melanoma B (Gpnmb), a transmembrane glycoprotein that is expressed in macrophages, negatively regulates inflammation. We have reported that Gpnmb is strongly expressed in the livers of rats fed a choline-deficient, L-amino

Externí odkaz: https://doaj.org/article/2ebe0f32e9c8445a989f507947fcbb0c

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Akademický článek

Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.

Autor: Seiichi Mawatari, Hirofumi Uto, Akio Ido, Kenji Nakashima, Tetsuro Suzuki, Shuji Kanmura, Kotaro Kumagai, Kohei Oda, Kazuaki Tabu, Tsutomu Tamai, Akihiro Moriuchi, Makoto Oketani, Yuko Shimada, Masayuki Sudoh, Ikuo Shoji, Hirohito Tsubouchi

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82094 (2013)

BACKGROUND: It has been hypothesized that persistent hepatitis C virus (HCV) infection is mediated in part by viral proteins that abrogate the host immune response, including the complement system, but the precise mechanisms are not well understood.

Externí odkaz: https://doaj.org/article/045de7e95e3b4de894a64d7ef4fb68db

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