Výsledky vyhledávání - "KATIE C. COATE"

Akademický článek

Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways

Autor: Yulong Gong, Bingyuan Yang, Dingdong Zhang, Yue Zhang, Zihan Tang, Liu Yang, Katie C. Coate, Linlin Yin, Brittney A. Covington, Ravi S. Patel, Walter A. Siv, Katelyn Sellick, Matthew Shou, Wenhan Chang, E. Danielle Dean, Alvin C. Powers, Wenbiao Chen

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

Insufficient glucagon signalling results in hyperaminoacidemia, which drives adaptive proliferation of glucagon-producing α cells. Here the authors report that the amino acid sensitive calcium sensing receptor (CaSR) is necessary for α cell prolife

Externí odkaz: https://doaj.org/article/654699dbaee24375b1033c131a876439

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Akademický článek

Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

Autor: Jason G. Anderson, Giorgio Ramadori, Rafael M. Ioris, Mirco Galiè, Eric D. Berglund, Katie C. Coate, Teppei Fujikawa, Stefania Pucciarelli, Benedetta Moreschini, Augusto Amici, Cristina Andreani, Roberto Coppari

Publikováno v: Molecular Metabolism, Vol 4, Iss 11, Pp 846-856 (2015)

Objective: Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting protective effects against these metabolic imbalances is of enormous medical significance. Sirt6 loss-

Externí odkaz: https://doaj.org/article/342ca602a10d4d6e8cd7632471dd0105

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Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

Autor: Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Jon Hastings, Alan D. Cherrington, Dale S. Edgerton

Publikováno v: Diabetes. 72:196-209

Endogenous insulin secretion is a key regulator of postprandial hepatic glucose metabolism, but this process is dysregulated in diabetes. Subcutaneous insulin delivery alters normal insulin distribution, causing relative hepatic insulin deficiency an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d1800212904726a665b8284e047a37
https://doi.org/10.2337/db22-0471

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A pragmatic low carbohydrate diet intervention changes neither carbohydrate consumption nor glycemia in adolescents and young adults with type 1 diabetes in a randomized trial

Autor: Sara H. Duffus, James C. Slaughter, William Cooley, Navila Sharif, Kimberly Rainer, Katie C. Coate, Sarah S. Jaser, Daniel J. Moore, Kevin D. Niswender, Justin M. Gregory

Publikováno v: Pediatr Diabetes

OBJECTIVE: Despite enthusiasm for low carbohydrate diets (LCDs) among patients with type 1 diabetes (T1DM), no prospective study has investigated outcomes in adolescent T1DM. We aimed to quantify a pragmatic LCD intervention’s impact on glycemia, l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8254b820a5f89aee9754fe56b27a9e
https://doi.org/10.1111/pedi.13407

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365-OR: Interruption of Glucagon Signaling Increases Delta-Cell Proliferation in Mouse and Human Islets

Autor: CHUNHUA DAI, AMBER BRADLEY, ERICK SPEARS, AJAY K. SINGH, FAVOUR O. OLADIPUPO, REGINA JENKINS, KATIE C. COATE, ALVIN C. POWERS

Publikováno v: Diabetes. 71

The determinants of delta cell mass are not known. As part of studies showing interruption of glucagon signaling (IGS) stimulates alpha cell proliferation in an amino acid (AA) -dependent manner, we noted an increase in delta cells. To investigate, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e48b1fdcfac3123013e81edbee99499
https://doi.org/10.2337/db22-365-or

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1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

Autor: DALE S. EDGERTON, GUILLAUME KRAFT, KATIE C. COATE, BEN FARMER, MARTA S. SMITH, MELANIE SCOTT, JON R. HASTINGS, MARY C. MOORE, ALAN D. CHERRINGTON

Publikováno v: Diabetes. 71

High fat and fructose diets (HFFD) disrupt glucose metabolism. The aim of this study was to determine the effect of HFFD on glucagon (GGN) effectiveness. Dogs were fed either chow or HFFD for one month. After a basal sampling period, somatostatin and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ec96c910c1958597b705e0d3e142f41
https://doi.org/10.2337/db22-1341-p

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260-LB: Elucidating the Role of NTPDase3 and Purinergic Signaling in Islet Hormone Secretion

Autor: TIFFANY M. RICHARDSON, CHUNHUA DAI, RADHIKA ARAMANDLA, HEATHER H. DURAI, CONRAD REIHSMANN, COREY DAVIS, SHAOJUN MEI, DANNIELLE GIBSON, SHRISTI SHRESTHA, DIANE C. SAUNDERS, KATIE C. COATE, SIMON C. ROBSON, ALVIN C. POWERS, MARCELA BRISSOVA

Publikováno v: Diabetes. 71

ATP release from β cell secretory vesicles during insulin exocytosis is postulated to modulate islet hormone secretion via purinergic signaling in an autocrine or paracrine manner. Ecto-enzymes, including a family of ectonucleotidases (NTPDase) , co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d89daa86a9ada689d1973feefa22b24
https://doi.org/10.2337/db22-260-lb

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Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between mTORC1 and CaSR-Gq signaling pathways

Autor: Linlin Yin, Walter Siv, Katie C. Coate, Ravi Patel, Yulong Gong, Brittney A. Covington, Bingyuan Yang, Danielle Dean, Wenbiao Chen, Alvin C. Powers, Zihan Tang, Liu Yang, Ding-Dong Zhang

Glucagon has emerged as the main regulator of extracellular amino acid homeostasis. Insufficient glucagon signaling results in hyperaminoacidemia, which drives adaptive proliferation of glucagon-producing α cells. Aside from mammalian target of rapa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f20e79c574261ec72812c11d52e8dd24
https://doi.org/10.21203/rs.3.rs-798563/v1

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Insulin Infusion Is Linked to Increased NPPC Expression in Muscle and Plasma C-type Natriuretic Peptide in Male Dogs

Autor: Ben Farmer, Yan Ru Su, Kelsey Tomasek, Guillaume Kraft, Katie C. Coate, David C. Laneve, Christopher S Wilson, Justin M. Gregory, Mark D Thompson, Marta S. Smith, Alan D. Cherrington, Phillip E. Williams

Publikováno v: Journal of the Endocrine Society

The purpose of this study was to assess insulin-stimulated gene expression in canine skeletal muscle with a particular focus on NPPC, the gene that encodes C-type natriuretic peptide, a key hormonal regulator of cardiometabolic function. Four conscio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c81a99951d76ddfe7ce4fe10abba351
http://europepmc.org/articles/PMC8195255

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The Importance of the Mechanisms by which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

Autor: Melanie Scott, Marta S. Smith, Alan D. Cherrington, Ben Farmer, Dale S. Edgerton, Guillaume Kraft, Katie C. Coate

Publikováno v: Diabetes

Hepatic glucose uptake (HGU) is critical for maintaining normal postprandial glucose metabolism. Insulin is clearly a key regulator of HGU, but the physiologic mechanisms by which it acts have yet to be established. This study sought to determine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051774454963799d902e4aa398b405a6
https://doi.org/10.2337/figshare.14242049.v1

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