Zobrazeno 1 - 10
of 23
pro vyhledávání: '"KASH domains"'
Autor:
Alexandre Chojnowski, Colin L. Stewart, Lois Yu En Sim, Yin Loon Lee, Choong Tat Keng, Matias Ilmari Autio, Tuan Danh Anh Luu, Ying Jie Loh, Khaing Thet Nyein, Roger Foo, Michael A. Ferenczi, Brian Burke, Shi Ling Ng, Kenneth Kian Boon Tan, Bhavya Sharma, Irina Solovei, Yu Haiyang, Jason Wen Long Cheong, Ruth Jinfen Chai, Peter Yiqing Li, Edita Aliwarga, Raju Navasankari, Martina Maric, Hendrikje Werner, Wei Leong Chew
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy. Here we show that mice with a cardiomyocyte-specific Lmna deletion develop cardiac failure and die within 3–4 weeks after inducing the mutation. When the same Lmna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afa6944b68830856ba3cb421879425b
http://europepmc.org/articles/PMC8342462
http://europepmc.org/articles/PMC8342462
Autor:
Akshay Rathish, Vyom Thakkar, Daniel A. Starr, Venecia A. Valdez, Uyen T. Vu, Hongyan Hao, Zeinab Jahed, Chris Tolentino, Samuel C. J. Kim, Darya Fadavi, Mohammad R. K. Mofrad
Publikováno v:
Molecular Biology of the Cell
The linker of the nucleoskeleton and cytoskeleton (LINC) complex is formed by the conserved interactions between Sad-1 and UNC-84 (SUN) and Klarsicht, ANC-1, SYNE homology (KASH) domain proteins, providing a physical coupling between the nucleoskelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd75bd19b7a1bff50f41f1a7c88f550
https://doi.org/10.1091/mbc.e19-02-0079
https://doi.org/10.1091/mbc.e19-02-0079
Autor:
Shilpi Kalra, Daniel A. Starr, Leslie A Guerrero, Natalie E. Cain, Hongyan Hao, Laura E Jameson, Jessica Bolivar
Publikováno v:
eLife, Vol 10 (2021)
KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of linker of nucleoskeleton and cytoskeleton (LINC) complexes that connect nuclei to the cytoskeleton. Caenorhabditis elegans ANC-1, an ortholog of Nesprin-1/2, contains actin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dc98a25ba37fbb4c251a8916e9d56b
https://elifesciences.org/articles/61069
https://elifesciences.org/articles/61069
Autor:
Shilpi Kalra, Jessica Bolivar, Laura E Jameson, Hongyan Hao, Daniel A. Starr, Natalie E. Cain, Leslie A Guerrero
KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of LINC complexes that connect nuclei to the cytoskeleton.Caenorhabditis elegansANC-1, an ortholog of Nesprin-1/2, contains actin-binding and KASH domains at opposite ends of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b19c183cc7a033f00d5452171c0ad5
https://doi.org/10.1101/2020.07.14.202838
https://doi.org/10.1101/2020.07.14.202838
Publikováno v:
Epigenomes, Vol 2, Iss 3, p 15 (2018)
Epigenomes
Epigenomes
Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms. Among these, constituents of the nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e65beb389e3c2ccff723fc4da39c154
http://www.mdpi.com/2075-4655/2/3/15
http://www.mdpi.com/2075-4655/2/3/15
Autor:
Didier Hodzic, David Razafsky
Publikováno v:
genesis. 52:359-365
Migration and anchorage of nuclei within developing and adult tissues rely on Linkers of the Nucleoskeleton to the Cytoskeleton (LINC complexes). These macromolecular assemblies span the nuclear envelope and physically couple chromatin and nuclear la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d9075704796554994cd7fe2216dbff7
https://doi.org/10.1002/dvg.22755
https://doi.org/10.1002/dvg.22755
Autor:
Zeinab Jahed, Akshay Rathish, Venecia A. Valdez, Mohammad R. K. Mofrad, Darya Fadavi, Vyom Thakkar, Uyen T. Vu, Hongyan Hao, Daniel A. Starr
Publikováno v:
Biophysical Journal. 116:412a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::170cfae6b5812f440f9ef241b806db20
https://doi.org/10.1016/j.bpj.2018.11.2223
https://doi.org/10.1016/j.bpj.2018.11.2223
Publikováno v:
NUCLEUS-AUSTIN
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the double membrane of the nuclear envelope (NE) and physically connect nuclear structures to cytoskeletal elements. LINC complexes are envisioned as force transducers in the NE, which f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06db9523a9453bbd5d917e18edbf1034
https://doi.org/10.4161/nucl.23387
https://doi.org/10.4161/nucl.23387
Publikováno v:
Molecular Biology of the Cell. 20:4586-4595
Klarsicht/ANC-1/Syne/homology (KASH)/Sad-1/UNC-84 (SUN) protein pairs can act as connectors between cytoplasmic organelles and the nucleoskeleton. Caenorhabditis elegans ZYG-12 and SUN-1 are essential for centrosome–nucleus attachment. Although SUN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1847519cc03a7a0379677e8b1f5afe72
https://doi.org/10.1091/mbc.e08-10-1034
https://doi.org/10.1091/mbc.e08-10-1034
Publikováno v:
Journal of Visualized Experiments.
Nuclear migration and anchorage within developing and adult tissues relies heavily upon large macromolecular protein assemblies called LInkers of the Nucleoskeleton and Cytoskeleton (LINC complexes). These protein scaffolds span the nuclear envelope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030dd1c067bf984394151bec81dd7a39
https://doi.org/10.3791/53318
https://doi.org/10.3791/53318