Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted/founder sensitivity to broadly neutralizing antibodies

Autor: Durgadevi Parthasarathy, Karunakar Reddy Pothula, Sneha Ratnapriya, Héctor Cervera Benet, Ruth Parsons, Xiao Huang, Salam Sammour, Katarzyna Janowska, Miranda Harris, Joseph Sodroski, Priyamvada Acharya, Alon Herschhorn

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract HIV-1 envelope glycoproteins (Envs) of most primary HIV-1 strains exist in closed conformation and infrequently sample open states, limiting access to internal epitopes. Thus, immunogen design aims to mimic the closed Env conformation as pre

Externí odkaz: https://doaj.org/article/586e2ac8dde84379b0e08159c9302824

Predicting deep infection in pilon and tibial plateau fractures: a secondary analysis of the VANCO and OXYGEN trials

Autor: Archie L. Overmann, MD, Anthony R. Carlini, MS, Robert V. O'Toole, MD, Renan C. Castillo, PhD, Nathan N. O'Hara, PhD, MHA, METRC, Eben A. Carroll, MD, James Brett Goodman, MBA, Martha B. Holden, AAS, AA, Anna N. Miller, MD, Amanda Spraggs-Hughes, PhD, Michael L. Brennan, MD, Paul Tornetta, III, MD, Patrick M. Osborn, MD, Jessica C. Rivera, MD, PhD, Clinton K. Murray, MD, Joseph E. Kimmel, MS, Michael J. Bosse, MD, Joseph R. Hsu, MD, Madhav A. Karunakar, MD, Laurence B. Kempton, MD, Rachel B. Seymour, PhD, Stephen H. Sims, MD, Christine Churchill, MA, Debra L. Sietsema, PhD, RN, Ida Leah Gitajn, MD, MS, Rachel M. Reilly, MD, Robert D. Zura, MD, Cameron Howes, BA, Hassan Mir, MD, MBA, Michael J. Weaver, MD, Marilyn Heng, MD, MPH, Thuan V. Ly, MD, Emily A. Wagstrom, MD, Jerald R. Westberg, MPH, BA, Brian H. Mullis, MD, Jeffrey O. Anglen, MD, Leilani S. Mullis, MD, Karl D. Shively, MD, Todd O. McKinley, MD, Roman M. Natoli, MD, PhD, Anthony Sorkin, MD, Lauren C. Hill, BS, CCRC, Robert A. Hymes, MD, Greg E. Gaski, MD, A. Stephen Malekzadeh, MD, Lolita Ramsey, PhD, RN, Jeff E. Schulman, MD, Cary C. Schwartzbach, MD, Robert A. Sikorski, MD, Olivia C. Lee, MD, Peter C. Krause, MD, Joshua L. Gary, MD, Timothy S. Achor, MD, Andrew Choo, MD, John W. Munz, MD, Sterling J. Boutte, BS, Matthew C. Galpin, CCRC, H. Michael Frisch, MD, Adam M. Kaufman, MD, C. Michael LeCroy, MD, Christopher S. Smith, MD, Alec C. Stall, MD, MPH, Andrea Horne, MA, CCRP, Manjari Joshi, MBBS, Jason W. Nascone, MD, Marcus F. Sciadini, MD, Gerard P. Slobogean, MD, Andrea L. Howe, BS, Roman Hayda, MD, Andrew R. Evans, MD, Stanislaw P. Stawicki, MD, MBA, Thomas R. Wojda, MD, MBA, Michael J. Gardner, MD, Julius A. Bishop, MD, Saqib Rehman, MD, MBA, Cyrus Caroom, MD, Elizabeth Sheridan, MPH, MACPR, Theodore Miclau, MD, Saam Morshed, MD, PhD, Thomas F. Higgins, MD, Justin M. Haller, MD, Clay A. Spitler, MD, Massimo Max Morandi, MD, FACS, Paul Edward Matuszewski, MD, Arun Aneja, MD, PhD, Patrick F. Bergin, MD, Eldrin Bhanat, MD, MPH, Matt L. Graves, MD, John Morellato, MBBS Hons, David Teague, MD, William Ertl, MD, Jaimo Ahn, MD, PhD, Gele B. Moloney, MD, John C. Weinlein, MD, Boris A. Zelle, MD, Animesh Agarwal, MD, Ravi A. Karia, MD, Ashoke Sathy, MD, Drew Sanders, MD, MPH, David B. Weiss, MD, Seth R. Yarboro, MD, Veronica Lester-Ballard, MSN, Eric D. McVey, MEd, CCRP, Reza Firoozabadi, MD, MA, Arman Dagal, MD, FRCA, Conor P. Kleweno, MD, Julie Agel, MA, Paul S. Whiting, MD, Natasha M. Simske, BS, Alexander B. Siy, BS, William T. Obremskey, MD, MPH, Basem Attum, MD, Eduardo J. Burgos, MD, Vamshi Gajari, MBBS, A. Alex Jahangir, MD, Andres Rodriguez-Buitrago, MD, Manish Sethi, MD, Daniel J. Stinner, MD, PhD, Rajesh R. Tummuru, MBBS, MBA, Karen M. Trochez, MA, BS, Jean-Claude G. D'Alleyrand, MD, MSE, Lauren E. Allen, DrPH, Susan C. Collins, MSc, Yanjie Huang, ScM, Tara J. Taylor, MPH

Publikováno v: OTA International, Vol 7, Iss 4 (2024)

Abstract. Objectives:. To develop and validate a prediction model for a deep surgical site infection (SSI) after fixation of a tibial plateau or pilon fracture. Design:. Pooled data from 2 randomized trials (VANCO and OXYGEN). Setting:. Fifty-two US

Externí odkaz: https://doaj.org/article/f526c1bca38a46778b5055dcf59b14aa

Disguised face liveness detection: an ensemble approach using deep features

Autor: Padmashree G., Karunakar A. K.

Publikováno v: Cogent Engineering, Vol 11, Iss 1 (2024)

Deep learning models have surpassed classic machine learning models in face anti-spoofing detection during the last decade. Most face-spoofing detection algorithms are biased toward a single presentation attack, failing to robustly detect multiple sp

Externí odkaz: https://doaj.org/article/c545f03eee3048fcadc4ab7a37f3292a

CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer

Autor: Ganesh Acharya, Chinnadurai Mani, Naresh Sah, Karunakar Saamarthy, Robert Young, Mark B. Reedy, Robert W. Sobol, Komaraiah Palle

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-15 (2024)

Abstract Chemoresistance contributes to the majority of deaths in women with ovarian cancer (OC). Altered DNA repair and metabolic signaling is implicated in mediating therapeutic resistance. DNA damage checkpoint kinase 1 (CHK1) integrates cell cycl

Externí odkaz: https://doaj.org/article/fc36ae4b6fdf4aff9425053db2638baa

Evaluation of the Efficacy of Neo-endo, Hyflex Re-treatment File Systems and H-Files for Removing Gutta-Percha From Root Canal Treated Tooth by Using Stereomicroscope—An In Vitro Study

Autor: Karunakar P, Ranga Reddy M S, Karteek Basa Srinivas, Lakshmi Charan Reddy Chavva, Swetha Chigurupati, Racha Kundana, Waheed Sumaiya

Publikováno v: Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss 6, Pp 1695-1699 (2024)

AimTo evaluate the efficacy of Neo-endo, Hyflextm retreatment file systems, and H-files for removing gutta-percha from root canal treated tooth. Materials and MethodsThirty extracted single-rooted human teeth with a single canal were opted. The shapi

Externí odkaz: https://doaj.org/article/59d755409b904dd5af77eecf937a5a10