Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

Autor: Mullish, Benjamin H., McDonald, Julie A. K., Pechlivanis, Alexandros, Allegretti, Jessica R., Kao, Dina, Barker, Grace F., Kapila, Diya, Petrof, Elaine O., Joyce, Susan A., Gahan, Cormac G., Glegola-Madejska, Izabela, Williams, Horace R. T., Holmes, Elaine, Clarke, Thomas B., Thursz, Mark R., Marchesi, Julian R.

Objective Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8c7bbc4a137a56ba402911e97a98f573
http://hdl.handle.net/10044/1/67139

Female role models in medicine: a medical student's perspective.

Autor: KAPILA, DIYA¹ diya.kapila@gmail.com

Publikováno v: Journal of Advances in Medical Education & Professionalism. Jan2018, Vol. 1 Issue 1, p49-50. 2p.

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Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection.

Autor: Mullish BH; Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., McDonald JAK; Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Pechlivanis A; Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Allegretti JR; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Harvard University, Boston, Massachusetts, USA., Kao D; Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada., Barker GF; Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Kapila D; Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Petrof EO; Division of Infectious Diseases/ GI Diseases Research Unit Wing, Department of Medicine, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada., Joyce SA; APC Microbiome Institute, University College Cork, Cork, Ireland.; School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland., Gahan CGM; APC Microbiome Institute, University College Cork, Cork, Ireland.; School of Pharmacy, University College Cork, Cork, Ireland., Glegola-Madejska I; MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK., Williams HRT; Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Holmes E; Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Clarke TB; MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, UK., Thursz MR; Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK., Marchesi JR; Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.; School of Biosciences, Cardiff University, Cardiff, UK.

Publikováno v: Gut [Gut] 2019 Oct; Vol. 68 (10), pp. 1791-1800. Date of Electronic Publication: 2019 Feb 11.