Zobrazeno 1 - 10
of 169
pro vyhledávání: '"KANG JIN JEONG"'
Autor:
Jennifer M. Finan, Roberto Di Niro, Soon Young Park, Kang Jin Jeong, Madeline D. Hedberg, Alexander Smith, Grace A. McCarthy, Alex O. Haber, John Muschler, Rosalie C. Sears, Gordon B. Mills, William H. Gmeiner, Jonathan R. Brody
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease soon to become the second leading cause of cancer deaths in the US. Beside surgery, current therapies have narrow clinical benefits with systemic toxicities. FOLFIRINOX is the current standa
Externí odkaz:
https://doaj.org/article/31179cb813084425aaab19da48c81dcf
Autor:
Xi Li, Alfonso Poire, Kang Jin Jeong, Dong Zhang, Tugba Yildiran Ozmen, Gang Chen, Chaoyang Sun, Gordon B. Mills
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Although Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have been approved in multiple diseases, including BRCA1/2 mutant breast cancer, responses are usually transient requiring the deployment of combination therapies for optimal ef
Externí odkaz:
https://doaj.org/article/87332cc7bc164961bc45782eb7c90b2e
Autor:
Soon Young Park, Kang Jin Jeong, Alfonso Poire, Dong Zhang, Yiu Huen Tsang, Aurora S. Blucher, Gordon B. Mills
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)
Abstract Ferroptosis, a form of programed cell death, can be promoted by inhibitors of the xCT transporter (erastin) or GPX4 (RSL3). We found that GPX4, but not the xCT transporter, is selectively elevated in luminal breast cancer. Consistent with th
Externí odkaz:
https://doaj.org/article/ff2915ae1db14ee2ab69ef8e7bbe97b4
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-17 (2023)
Abstract Bromo- and extra-terminal domain (BET) inhibitors (BETi) have been shown to decrease tumor growth in preclinical models and clinical trials. However, toxicity and rapid emergence of resistance have limited their clinical implementation. To i
Externí odkaz:
https://doaj.org/article/06d75379cd0b419d90459f84d9119855
Autor:
Hanseop Kim, Wi-jae Lee, Chan Hyoung Kim, Yeounsun Oh, Lee Wha Gwon, Hyomin Lee, Woojeung Song, Junho K. Hur, Kyung-Seob Lim, Kang Jin Jeong, Ki-Hoan Nam, Young-Suk Won, Kyeong-Ryoon Lee, Youngjeon Lee, Young-Hyun Kim, Jae-Won Huh, Bong-Hyun Jun, Dong-Seok Lee, Seung Hwan Lee
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 353-362 (2022)
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a system is composed of a Cas12a effector that acts as a DNA-cleaving endonuclease and a crispr RNA (crRNA) that guides the effector to the target DNA. It is considered a key
Externí odkaz:
https://doaj.org/article/ca3da64f7d3e427f968243ed76e0d3c6
Autor:
Jincheol Seo, Kyung Seob Lim, Chang-Yeop Jeon, SeungHo Baek, Hyeon-Gu Yeo, Won Seok Choi, Sung-Hyun Park, Kang Jin Jeong, Jinyoung Won, Keonwoo Kim, Junghyung Park, Jiyeon Cho, Jung Bae Seong, Minji Kim, Yu Gyeong Kim, Jae-Won Huh, Samhwan Kim, Yong Hoon Lim, Hyung Woo Park, Hye Min Tak, Man Seong Heo, Ji-Woong Choi, Sun Ha Paek, Youngjeon Lee
Publikováno v:
Parkinson's Disease, Vol 2022 (2022)
The hemiparkinsonian nonhuman primate model induced by unilateral injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the carotid artery is used to study Parkinson’s disease. However, there have been no studies that the contralate
Externí odkaz:
https://doaj.org/article/e184de2df2f743b4a3850a8b75c98e5a
Autor:
Carman K. M. Ip, Patrick K. S. Ng, Kang Jin Jeong, S. H. Shao, Zhenlin Ju, P. G. Leonard, Xu Hua, Christopher P. Vellano, Richard Woessner, Nidhi Sahni, Kenneth L. Scott, Gordon B. Mills
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Activation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomo
Externí odkaz:
https://doaj.org/article/5afbb5f4318a4d348864297344880429
Autor:
Jue Wang, Wei Zhao, Huifang Guo, Yong Fang, Sarah Elizabeth Stockman, Shanshan Bai, Patrick Kwok-Shing Ng, Yang Li, Qinghua Yu, Yiling Lu, Kang Jin Jeong, Xiaohua Chen, Meng Gao, Jiyong Liang, Wentao Li, Xingsong Tian, Eric Jonasch, Gordon B. Mills, Zhiyong Ding
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Aberrant AKT activation is prevalent across human cancer lineages, providing an important therapeutic target. AKT comprises three isoforms that mediate critical non-redundant, even opposing functions in cancer pathophysiology. The
Externí odkaz:
https://doaj.org/article/9749cf56d10842c794d00f85219d164d
Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer
Autor:
Pradeep Chaluvally-Raghavan, Kang Jin Jeong, Sunila Pradeep, Andreia Machado Silva, Shuangxing Yu, Wenbin Liu, Tyler Moss, Cristian Rodriguez-Aguayo, Dong Zhang, Prahlad Ram, Jinsong Liu, Yiling Lu, Gabriel Lopez-Berestein, George A. Calin, Anil K. Sood, Gordon B. Mills
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1493-1504 (2016)
Summary: 3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome. Importantly, miR551b-3p contributes to resistance to apoptosis and increase
Externí odkaz:
https://doaj.org/article/73ebc2f1874e4686a858da0b14630166
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 1, Pp 25-35 (2016)
The ectonucleotide pyrophosphatase/phosphodiesterase type 2, more commonly known as autotaxin (ATX), is an ecto-lysophospholipase D encoded by the human ENNP2 gene. ATX is expressed in multiple tissues and participates in numerous key physiologic and
Externí odkaz:
https://doaj.org/article/f49dfcf39e814220b3cc2027325879ea