Visualizing protein–ligand binding with chemical energy-wise decomposition (CHEWD): application to ligand binding in the kallikrein-8 S1 Site

Autor: Christopher J. Woods, Saad Raza, Adrian J. Mulholland, Syed Sikander Azam, Marc W. van der Kamp, Kara E. Ranaghan

Publikováno v: Raza, S, Ranaghan, K, Van der Kamp, M, Woods, C, Mulholland, A & Azam, S S 2019, ' Visualizing protein–ligand binding with chemical energy-wise decomposition (CHEWD) : application to ligand binding in the kallikrein-8 S1 Site ', Journal of Computer-Aided Molecular Design, vol. 33, no. 5, pp. 461-475 . https://doi.org/10.1007/s10822-019-00200-4

Kallikrein-8, a serine protease, is a target for structure-based drug design due to its therapeutic potential in treating Alzheimer’s disease and is also useful as a biomarker in ovarian cancer. We present a binding assessment of ligands to kallikr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6e47ad830ef5d355605da5b82415f7
https://doi.org/10.1007/s10822-019-00200-4

Increase of Serum Kallikrein-8 Level After Long-term Telbivudine Treatment

Autor: Haw-En Wang, Chau-Ting Yeh, Chih-Lang Lin, Tai-Long Pan

Publikováno v: In vivo (Athens, Greece). 32(4)

Background/Aim: Our previous cDNA microarray study revealed increased cellular mRNA levels of a panel of genes, including kallikrein-8 (KLK8), after long-term telbivudine treatment in chronic hepatitis B patients. The aim of this study was to verify

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e82130b5f0650445e0af9b9dd702d4b
https://pubmed.ncbi.nlm.nih.gov/29936485

Structure modeling and hybrid virtual screening study of Alzheimer’s associated protease kallikrein 8 for the identification of novel inhibitors

Autor: Saad Raza, Syed Sikander Azam

Publikováno v: Medicinal Chemistry Research. 23:3516-3527

Kallikrein 8 (KLK8) is an extra cellular serine protease which is responsible for nerve growth, and degeneration and nervous plasticity have been associated with Alzheimer’s disease. In silico analysis of KLK8 has not been performed until now. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dad519cf425b1191217d9d010f5a1f5
https://doi.org/10.1007/s00044-014-0932-1

Kallikrein 8 Is Involved in Skin Desquamation in Cooperation with Other Kallikreins

Autor: Yoshio Bando, Mari Kishibe, Kazuhiko Namikawa, Ying Ping Jiang, Hidetoshi Takahashi, Hajime Iizuka, Ryuji Terayama, Shigetaka Yoshida, Yoshio Hashimoto, Daniel Perez, Akemi Ishida-Yamamoto, Branka Mitrovic

Publikováno v: Journal of Biological Chemistry. 282:5834-5841

Kallikrein type serine proteases, KLK8/neuropsin, KLK6, and KLK7, have been implicated in the proliferation and differentiation of epidermal keratinocytes and in the pathogenesis of psoriasis. However, their mechanistic roles in these processes remai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb9e9d05d21973b2dd3b6ad6a15d127
https://doi.org/10.1074/jbc.m607998200

Human Kallikrein 8 Protein Is a Favorable Prognostic Marker in Ovarian Cancer

Autor: Eleftherios P. Diamandis, Manfred Schmitt, Barbara Schmalfeldt, Julia Dorn, Andreas Scorilas, Nadia Harbeck, Carla A. Borgoño, Tadaaki Kishi

Publikováno v: Clinical Cancer Research. 12:1487-1493

Human kallikrein 8 (hK8/neuropsin/ovasin; encoded by KLK8) is a steroid hormone–regulated secreted serine protease differentially expressed in ovarian carcinoma. KLK8 mRNA levels are associated with a favorable patient prognosis and hK8 protein lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c94ba6a8be4a595eee1e4f192d7297
https://doi.org/10.1158/1078-0432.ccr-05-2106