Phage therapy to treat cystic fibrosis Burkholderia cepacia complex lung infections: perspectives and challenges

Autor: Jack S. Canning, Daniel R. Laucirica, Kak-Ming Ling, Mark P. Nicol, Stephen M. Stick, Anthony Kicic

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

Burkholderia cepacia complex is a cause of serious lung infections in people with cystic fibrosis, exhibiting extremely high levels of antimicrobial resistance. These infections are difficult to treat and are associated with high morbidity and mortal

Externí odkaz: https://doaj.org/article/d8fee1ea23b34a9e8e68aff9f8a2236f

Pulmonary bacteriophage and cystic fibrosis airway mucus: friends or foes?

Autor: Kak-Ming Ling, Stephen Michael Stick, Anthony Kicic

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

For those born with cystic fibrosis (CF), hyper-concentrated mucus with a dysfunctional structure significantly impacts CF airways, providing a perfect environment for bacterial colonization and subsequent chronic infection. Early treatment with anti

Externí odkaz: https://doaj.org/article/ec3e016abd444c048e9b94ce0ba008c5

Persistent activation of interlinked type 2 airway epithelial gene networks in sputum-derived cells from aeroallergen-sensitized symptomatic asthmatics

Autor: Anya C. Jones, Niamh M. Troy, Elisha White, Elysia M. Hollams, Alexander M. Gout, Kak-Ming Ling, Anthony Kicic, Stephen M. Stick, Peter D. Sly, Patrick G. Holt, Graham L. Hall, Anthony Bosco

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Abstract Atopic asthma is a persistent disease characterized by intermittent wheeze and progressive loss of lung function. The disease is thought to be driven primarily by chronic aeroallergen-induced type 2-associated inflammation. However, the vast

Externí odkaz: https://doaj.org/article/3ac16e7684d348ea85dff8c594b24574

Elucidating the Interaction of CF Airway Epithelial Cells and Rhinovirus: Using the Host-Pathogen Relationship to Identify Future Therapeutic Strategies

Autor: Kak-Ming Ling, Luke W. Garratt, Timo Lassmann, Stephen M. Stick, Anthony Kicic, WAERP, AusREC, Australian Respiratory Early Surveillance Team for Cystic Fibrosis

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Chronic lung disease remains the primary cause of mortality in cystic fibrosis (CF). Growing evidence suggests respiratory viral infections are often more severe in CF compared to healthy peers and contributes to pulmonary exacerbations (PEx) and det

Externí odkaz: https://doaj.org/article/1f28780486404eeaa2d400272e238b36

Dysregulated Notch Signaling in the Airway Epithelium of Children with Wheeze

Autor: Thomas Iosifidis, Erika N. Sutanto, Samuel T. Montgomery, Patricia Agudelo-Romero, Kevin Looi, Kak-Ming Ling, Nicole C. Shaw, Luke W. Garratt, Jessica Hillas, Kelly M. Martinovich, Elizabeth Kicic-Starcevich, Shyan Vijayasekaran, Francis J. Lannigan, Paul J. Rigby, Darryl A. Knight, Stephen M. Stick, Anthony Kicic

Publikováno v: Journal of Personalized Medicine
Journal of Personalized Medicine; Volume 11; Issue 12; Pages: 1323
Journal of Personalized Medicine, Vol 11, Iss 1323, p 1323 (2021)

The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma. However, its role in airw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc981d9334620dc3f5d455ba0d140217
https://pubmed.ncbi.nlm.nih.gov/34945795