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Improved synthesis of (S)-N-Boc-5-oxaproline for protein synthesis with the α-ketoacid-hydroxylamine (KAHA) ligation

Autor: Thibault J. Harmand, Claudia E. Murar, Jeffrey W. Bode

Publikováno v: Bioorganic & Medicinal Chemistry, 25 (18)

We describe a new route for the synthesis of (S)-N-Boc-5-oxaproline. This building block is a key element for the chemical synthesis of proteins with the α-ketoacid-hydroxylamine (KAHA) ligation. The new synthetic pathway to the enantiopure oxaproli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ace6a1969865965aa9c8f0e9a95d28
https://doi.org/10.1016/j.bmc.2017.06.019

Chemical Synthesis of the Highly Hydrophobic Antiviral Membrane-Associated Protein IFITM3 and Modified Variants

Autor: Vijaya R. Pattabiraman, Jeffrey W. Bode, Thibault J. Harmand

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Angewandte Chemie. International Edition, 56 (41)
Angewandte Chemie (Weinheim an Der Bergstrasse, Germany)

Interferon-induced transmembrane protein 3 (IFITM3) is an antiviral transmembrane protein that is thought to serve as the primary factor for inhibiting the replication of a large number of viruses, including West Nile virus, Dengue virus, Ebola virus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d2cc9d4b51733455c714eb5e72dc64
https://pubmed.ncbi.nlm.nih.gov/28834009

Chemical Synthesis of Insulin Variants by KAHA Ligation

Autor: Boross, Gábor N.

Insulin is a protein hormone with a pivotal role in the regulation of numerous metabolic processes. Malfunction of insulin secretion or reduced sensitivity of the insulin receptor to its native ligand are the main reasons for diabetes mellitus. Recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e87ab64fab6e15623f7f1a7afdca6f
https://hdl.handle.net/20.500.11850/301883

Chemical Synthesis of Betatrophin and the Integral Membrane Protein IFITM3 by KAHA Ligation

Autor: Harmand, Thibault J.

Proteins are involved in and perform a myriad of biological functions. Understanding their structures, functions and interactions with small molecules or other proteins is essential for modern day science. In recent years, proteins as therapeutics ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13d39c2ba633ec63240cad8f25cad32
https://hdl.handle.net/20.500.11850/209686