Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis

Autor: Mukai, Kuniaki, Sugimoto, Hiroshi, Kamiya, Katsumasa, Suzuki, Reiko, Matsuura, Tomomi, Hishiki, Takako, Shimada, Hideo, Shiro, Yoshitsugu, Suematsu, Makoto, Kagawa, Norio

Publikováno v: In Current Research in Structural Biology 2021 3:192-205

Three-dimensional Structure of Steroid 21-Hydroxylase (Cytochrome P450 21A2) with Two Substrates Reveals Locations of Disease-associated Variants

Autor: Zhao, Bin, Lei, Li, Kagawa, Norio, Sundaramoorthy, Munirathinam, Banerjee, Surajit, Nagy, Leslie D., Guengerich, F. Peter, Waterman, Michael R.

Publikováno v: In Journal of Biological Chemistry 23 March 2012 287(13):10613-10622

Interaction between Substrate and Oxygen Ligand Responsible for Effective O–O Bond Cleavage in Bovine Cytochrome P450 Steroid 21-Hydroxylase Proved by Raman Spectroscopy

Autor: Tosha, Takehiko, Kagawa, Norio, Arase, Miharu, Waterman, Michael R., Kitagawa, Teizo

Publikováno v: In Journal of Biological Chemistry 15 February 2008 283(7):3708-3717

Molecular Basis of CYP19A1 Deficiency in a 46, XX Patient with R550W Mutation in POR: Expanding the PORD Phenotype

Autor: Parween, Shaheena, Fernández-Cancio, Mónica, Benito-Sanz, Sara, Camats, Núria, Velazquez, Maria Natalia Rojas, López-Siguero, Juan-Pedro, Udhane, Sameer S., Kagawa, Norio, Flück, Christa E., Audì, Laura, Pandey, Amit V.

Context: Mutations in Cytochrome P450 oxidoreductase (POR) cause a form of congenital adrenal hyperplasia (CAH). We are reporting a novel R550W mutation in POR identified in a 46, XX patient with signs of aromatase deficiency. Objective: Analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharePrprorg::aa13d9763c23adc1ee26d76876ee16d4

Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase

Autor: Parween, Shaheena, Rojas Velazquez, Maria Natalia, Udhane, Sameer S., Kagawa, Norio, Pandey, Amit V.

Publikováno v: Parween, Shaheena; Rojas Velazquez, Maria Natalia; Udhane, Sameer Sopanrao; Kagawa, Norio; Pandey, Amit Vikram (2019). Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase. Frontiers in Pharmacology, 10, p. 1187. Frontiers 10.3389/fphar.2019.01187

Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450 oxidoreductase (POR) for their catalytic activities. Mutations in POR cause multiple disorders in humans related to the biosynthesis of steroid hormones and also affe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64593882b4c84fa02fb422402f816227
https://boris.unibe.ch/138673/1/fphar-10-01187.pdf