Insulin purification-Innovation continuum via synthesis of fundamentals, technology, and modeling.

Autor: Roush D; Process R&D, Merck & Co., Inc, Rahway, New Jersey, USA., Iammarino M; Process R&D, Merck & Co., Inc, Rahway, New Jersey, USA., Chmielowski R; Process R&D, Merck & Co., Inc, Rahway, New Jersey, USA., Insaidoo F; Process R&D, Merck & Co., Inc, Rahway, New Jersey, USA., McCoy MA; Mass Spectrometry & Biophysics, Merck & Co., Inc, Kenilworth, New Jersey, USA., Ortigosa A; Merck & Co., Inc., Elkton, Virginia, USA., Rauscher M; Process R&D, Merck & Co., Inc, Rahway, New Jersey, USA.

Publikováno v: Biotechnology and bioengineering [Biotechnol Bioeng] 2024 Aug; Vol. 121 (8), pp. 2409-2422. Date of Electronic Publication: 2023 May 18.

Subsite differences between the active centres of papaya peptidase A and papain as revealed by affinity chromatography. Purification of papaya peptidase A by ionic-strength-dependent affinity adsorption on an immobilized peptide inhibitor of papain

Autor: Schack, P, Kaarsholm, N C

Publikováno v: Biochemical Journal; May 1984, Vol. 219 Issue: 3 p727-733, 7p

Spectroscopic signatures of the T to R conformational transition in the insulin hexamer*

Autor: Roy, M, Brader, M L, Lee, R W, Kaarsholm, N C, Hansen, J F, Dunn, M F

Publikováno v: Journal of Biological Chemistry; November 1989, Vol. 264 Issue: 32 p19081-19085, 5p

Structure‐based survey of ligand binding in the human insulin receptor.

Autor: Kumar, Lokender¹ (AUTHOR), Vizgaudis, Whitney² (AUTHOR), Klein‐Seetharaman, Judith^2,3 (AUTHOR) jkleinse@asu.edu

Publikováno v: British Journal of Pharmacology. Jul2022, Vol. 179 Issue 14, p3512-3528. 17p. 5 Diagrams, 2 Charts.

Glucose-sensitive insulin with attenuation of hypoglycaemia.

Autor: Hoeg-Jensen T; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Kruse T; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Brand CL; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Sturis J; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Fledelius C; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Nielsen PK; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Nishimura E; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Madsen AR; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Lykke L; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Halskov KS; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Koščová S; APIGENEX, Prague, Czech Republic., Kotek V; APIGENEX, Prague, Czech Republic., Davis AP; University of Bristol, Bristol, UK., Tromans RA; Carbometrics, Bristol, UK., Tomsett M; Carbometrics, Bristol, UK., Peñuelas-Haro G; Carbometrics, Bristol, UK., Leonard DJ; Carbometrics, Bristol, UK., Orchard MG; Carbometrics, Bristol, UK., Chapman A; Carbometrics, Bristol, UK., Invernizzi G; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Johansson E; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Granata D; Digital Science and Innovation, Novo Nordisk, Bagsværd, Denmark., Hansen BF; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Pedersen TA; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Kildegaard J; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Pedersen KM; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Refsgaard HHF; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Alifrangis L; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Fels JJ; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Neutzsky-Wulff AV; Global Research Technologies, Novo Nordisk, Bagsværd, Denmark., Sauerberg P; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark., Slaaby R; Global Drug Discovery, Novo Nordisk, Bagsværd, Denmark. risl@novonordisk.com.

Publikováno v: Nature [Nature] 2024 Oct; Vol. 634 (8035), pp. 944-951. Date of Electronic Publication: 2024 Oct 16.