Sustained intra-articular delivery of IL-1Ra from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis

Autor: KA Kimmerling, BD Furman, DS Mangiapani, MA Moverman, SM Sinclair, JL Huebner, A Chilkoti, VB Kraus, LA Setton, F Guilak, SA Olson

Publikováno v: European Cells & Materials, Vol 29, Pp 124-140 (2015)

Post-traumatic arthritis (PTA) is a rapidly progressive form of arthritis that develops due to joint injury, including articular fracture. Current treatments are limited to surgical restoration and stabilization of the joint; however, evidence sugges

Externí odkaz: https://doaj.org/article/8b17c52a17084fe9827e11567f17beb3

Hypothermically Stored Amnion Is Robust and Provides a Scaffold for Supporting Wound Healing by Retaining the Characteristics of Native Tissue.

Autor: Harmon KA; Organogenesis Discovery Center, Birmingham, AL 35243, USA., Kimmerling KA; Organogenesis Discovery Center, Birmingham, AL 35243, USA., Avery JT; Organogenesis Discovery Center, Birmingham, AL 35243, USA., Mowry KC; Organogenesis Discovery Center, Birmingham, AL 35243, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Sep 26; Vol. 25 (19). Date of Electronic Publication: 2024 Sep 26.

Bi-layered living cellular construct resulted in greater healing in an alloxan-induced diabetic porcine model.

Autor: Avery JT; Department of Research & Development, Organogenesis Inc., Canton, Massachusetts, USA., Qiao J; Editas Medicine, Cambridge, Massachusetts, USA., Medeiros E; Department of Quality Control, Organogenesis Inc., Canton, Massachusetts, USA., Bollenbach TJ; Advanced Regenerative Manufacturing Institute, Manchester, New Hampshire, USA., Kimmerling KA; Department of Research & Development, Organogenesis Inc., Canton, Massachusetts, USA., Mowry KC; Department of Research & Development, Organogenesis Inc., Canton, Massachusetts, USA.

Publikováno v: International wound journal [Int Wound J] 2023 Feb; Vol. 20 (2), pp. 403-412. Date of Electronic Publication: 2022 Aug 02.

Amniotic suspension allograft improves pain and function in a rat meniscal tear-induced osteoarthritis model.

Autor: Kimmerling KA; Department of Research & Development, Organogenesis, 2641 Rocky Ridge Lane, Birmingham, AL, 35216, USA., Gomoll AH; Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA., Farr J; Knee Preservation and Cartilage Restoration Center, OrthoIndy, Indianapolis, IN, USA., Mowry KC; Department of Research & Development, Organogenesis, 2641 Rocky Ridge Lane, Birmingham, AL, 35216, USA. kmowry@organo.com.

Publikováno v: Arthritis research & therapy [Arthritis Res Ther] 2022 Mar 04; Vol. 24 (1), pp. 63. Date of Electronic Publication: 2022 Mar 04.

Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice.

Autor: Vovos TJ; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA., Furman BD; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA., Huebner JL; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Kimmerling KA; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA.; Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA., Utturkar GM; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA., Green CL; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA., Kraus VB; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA.; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Guilak F; Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.; Shriners Hospital for Children-St. Louis, St. Louis, Missouri, USA., Olson SA; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2021 Sep; Vol. 39 (9), pp. 1977-1987. Date of Electronic Publication: 2020 Dec 08.