Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes

Autor: Colin M. Dayan, Parth Narendran, Wallace M. Macindoe, Nicola J. Leech, KA Elsegood, Geert-Jan Boons

Publikováno v: Immunology. 111:422-429

In vitro detection of T-cell responses to autoantigens in type 1 diabetes is recognized as being technically challenging. We aimed to accurately measure cellular responses to proinsulin in patients with diabetes, and speculated that presentation of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3a5a7b4014f3ae165854ca243c04d1
https://doi.org/10.1111/j.1365-2567.2004.01825.x

Effective formation of major histocompatibility complex class II-peptide complexes from endogenous antigen by thyroid epithelial cells

Autor: KA Elsegood, James B Uney, TC Harding, Ceh Stewart, R Maile, Colin M. Dayan, George Banting

Publikováno v: Immunology. 99:367-374

In autoimmune thyroid disease, thyroid epithelial cells (TEC) express major histocompatibility complex (MHC) class II molecules, potentially enabling them to present thyroid self-antigens to CD4-positive T cells. However, despite this, TEC may fail t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66b33f81bdf285e310d56251cdbd366f
https://doi.org/10.1046/j.1365-2567.2000.00958.x

ras Gene point mutation is a rare event in premalignant tissues and malignant cells and tissues from oral mucosal lesions

Autor: Stephen S. Prime, W.A. Yeudall, Paul M. Speight, KA Elsegood, LK Torrance, Crispian Scully

Publikováno v: European Journal of Cancer Part B: Oral Oncology. 29:63-67

Three series of biopsy specimens of premalignant and malignant oral lesions, together with seven human keratinocyte cultures, previously established from oral squamous cell carcinomas, were analysed for point mutation in exons 1 and 2 of the c-Ha-ras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9d74a11ac4a3550dd08273731bb81e
https://doi.org/10.1016/0964-1955(93)90012-4

FasL expression on epithelial cells: the Bottazzo-Feldman hypothesis revisited

Autor: Robert Maile, Colin M. Dayan, KA Elsegood

Publikováno v: Immunology today. 18(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec00ab7ec5377289a2ad7dd8a95b702d
https://pubmed.ncbi.nlm.nih.gov/9509765

Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence.

Autor: Fernández E; Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; KU Leuven, Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), and VIB Center for the Biology of Disease, Leuven, Belgium., Collins MO; Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Frank RAW; Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Zhu F; Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK., Kopanitsa MV; Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; Synome Ltd., Moneta Building, Babraham Research Campus, Cambridge, UK., Nithianantharajah J; Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK., Lemprière SA; Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK., Fricker D; Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; Synome Ltd., Moneta Building, Babraham Research Campus, Cambridge, UK., Elsegood KA; Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK., McLaughlin CL; Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK., Croning MDR; Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK., Mclean C; School of Informatics, Institute for Adaptive and Neural Computation, University of Edinburgh, UK., Armstrong JD; School of Informatics, Institute for Adaptive and Neural Computation, University of Edinburgh, UK., Hill WD; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, UK., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, UK., Cencelli G; KU Leuven, Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), and VIB Center for the Biology of Disease, Leuven, Belgium; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Bagni C; KU Leuven, Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), and VIB Center for the Biology of Disease, Leuven, Belgium; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Fromer M; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Purcell SM; Division of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Pocklington AJ; Institute of Psychological Medicine & Clinical Neurosciences, University of Cardiff, Cardiff, Wales, UK., Choudhary JS; Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK., Komiyama NH; Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK., Grant SGN; Genes to Cognition Programme, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK; Genes to Cognition Programme, Centre for Clinical Brain Science, University of Edinburgh, Edinburgh, UK. Electronic address: seth.grant@ed.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2017 Oct 17; Vol. 21 (3), pp. 679-691.