Zobrazeno 1 - 9 of 9 pro vyhledávání: '"KA Elsegood"'
1
Activated T cell subsets in human type 1 diabetes: evidence for expansion of the DR+ CD30+ subpopulation in new-onset disease
Autor: L. Chang, Colin M. Dayan, C. Baker, Amanda J. Bishop, D. H. Gannon, Nicola Leech, KA Elsegood, Parth Narendran
Publikováno v: Clinical and Experimental Immunology. 147:472-482
SummaryAn important limitation in T cell studies of human autoimmune (type 1) diabetes is lack of direct access to cells infiltrating the pancreas. We hypothesized that cells recently released from the pancreas into the blood might express a characte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b64b02d43416bd57a4d115070d220e
https://doi.org/10.1111/j.1365-2249.2006.03307.x
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2
Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes
Autor: Colin M. Dayan, Parth Narendran, Wallace M. Macindoe, Nicola J. Leech, KA Elsegood, Geert-Jan Boons
Publikováno v: Immunology. 111:422-429
In vitro detection of T-cell responses to autoantigens in type 1 diabetes is recognized as being technically challenging. We aimed to accurately measure cellular responses to proinsulin in patients with diabetes, and speculated that presentation of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3a5a7b4014f3ae165854ca243c04d1
https://doi.org/10.1111/j.1365-2567.2004.01825.x
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3
Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes
Autor: Parth Narendran, Colin M. Dayan, Alistair J K Williams, Nicola J. Leech, KA Elsegood
Publikováno v: Diabetes/Metabolism Research and Reviews. 19:52-59
Background: Type 1 diabetes (T1D) is an autoimmune disease characterized by immunity against pancreatic islet-derived proteins. The object of this study was to measure antibody and T-cell responses against proinsulin (PI), an islet-derived protein, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc713052881ef5c25c5f8187bb9f2b7
https://doi.org/10.1002/dmrr.332
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4
Effective formation of major histocompatibility complex class II-peptide complexes from endogenous antigen by thyroid epithelial cells
Autor: KA Elsegood, James B Uney, TC Harding, Ceh Stewart, R Maile, Colin M. Dayan, George Banting
Publikováno v: Immunology. 99:367-374
In autoimmune thyroid disease, thyroid epithelial cells (TEC) express major histocompatibility complex (MHC) class II molecules, potentially enabling them to present thyroid self-antigens to CD4-positive T cells. However, despite this, TEC may fail t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66b33f81bdf285e310d56251cdbd366f
https://doi.org/10.1046/j.1365-2567.2000.00958.x
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5
TGF-β isoforms fail to modulate inositol phosphates and cAMP in normal and tumour-derived human oral keratinocytes
Autor: KA Elsegood, Jonathan R Sandy, Adam J. Collier, Ian C. Paterson, Stephen S. Prime, W. Andrew Yeudall
Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1315(2):117-122
This study examined inositol phosphate and cAMP regulation by TGF-beta 1, -beta 2 and -beta 3 in normal and tumour-derived human oral keratinocytes. Previous findings indicated that the cell lines expressed TGF-beta cell surface receptors and had a r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894e1b3c21d054a524bda46417d3dd39
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6
ras Gene point mutation is a rare event in premalignant tissues and malignant cells and tissues from oral mucosal lesions
Autor: Stephen S. Prime, W.A. Yeudall, Paul M. Speight, KA Elsegood, LK Torrance, Crispian Scully
Publikováno v: European Journal of Cancer Part B: Oral Oncology. 29:63-67
Three series of biopsy specimens of premalignant and malignant oral lesions, together with seven human keratinocyte cultures, previously established from oral squamous cell carcinomas, were analysed for point mutation in exons 1 and 2 of the c-Ha-ras
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9d74a11ac4a3550dd08273731bb81e
https://doi.org/10.1016/0964-1955(93)90012-4
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7
Dendritic cell-based proliferative assays of peripheral T cell responses to tetanus toxoid
Autor: Nicola J. Leech, KA Elsegood, Colin M. Dayan, Parth Narendran
Publikováno v: Annals of the New York Academy of Sciences. 958
Antigen-specific proliferative responses of peripheral blood T cells are widely used in humans to study the T cell compartment. However, responses to autoantigens are often weak and poorly reproducible. Here we show, using a test recall antigen (teta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2c988f157a93cba67f93b221a53371
https://pubmed.ncbi.nlm.nih.gov/12021100
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