Zobrazeno 1 - 10
of 213
pro vyhledávání: '"K2P channels"'
Autor:
Elizabeth R. Elliott, Robin L. Cooper
Publikováno v:
Biology, Vol 13, Iss 9, p 750 (2024)
Regulating membrane potential is key to cellular function. For many animal cells, resting membrane potential is predominantly driven by a family of K2P (two-pore domain) potassium channels. These channels are commonly referred to as leak channels, as
Externí odkaz:
https://doaj.org/article/852e9a4ba83f4351b6fcf0cffd476264
Autor:
Bethany J. Ison, Maya O. Abul-Khoudoud, Sufia Ahmed, Abraham W. Alhamdani, Clair Ashley, Patrick C. Bidros, Constance O. Bledsoe, Kayli E. Bolton, Jerone G. Capili, Jamie N. Henning, Madison Moon, Panhavuth Phe, Samuel B. Stonecipher, Hannah N. Tanner, Logan T. Turner, Isabelle N. Taylor, Mikaela L. Wagers, Aaron K. West, Robin L. Cooper
Publikováno v:
NeuroSci, Vol 3, Iss 4, Pp 566-588 (2022)
The resting membrane potential enables neurons to rapidly initiate and conduct electrical signals. K2p channels are key in maintaining this membrane potential and electrical excitability. They direct the resting membrane potential toward the K+ equil
Externí odkaz:
https://doaj.org/article/19889a3056224445b0e62cd7153221c0
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Akademický článek
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Autor:
Robin L. Cooper, Rebecca M. Krall
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15787 (2022)
Bacterial septicemia is commonly induced by Gram-negative bacteria. The immune response is triggered in part by the secretion of bacterial endotoxin lipopolysaccharide (LPS). LPS induces the subsequent release of inflammatory cytokines which can resu
Externí odkaz:
https://doaj.org/article/51a86e2bf9ed47a39ffacf53512f49c5
Autor:
Rafael Zúñiga, Daniel Mancilla, Tamara Rojas, Fernando Vergara, Wendy González, Marcelo A. Catalán, Leandro Zúñiga
Publikováno v:
Biology, Vol 11, Iss 8, p 1097 (2022)
Two pore domain potassium channels (K2P) are strongly expressed in the nervous system (CNS), where they play a central role in excitability. These channels give rise to background K+ currents, also known as IKSO (standing-outward potassium current).
Externí odkaz:
https://doaj.org/article/bfec2ffb4ab54291a9e55489a349b6a7
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases. Potassium efflux has been reported to be essential for NLRP3 inflammasom
Externí odkaz:
https://doaj.org/article/0030c12c946942378309b5719555ef33
Akademický článek
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Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6635 (2021)
Years before the first two-pore domain potassium channel (K2P) was cloned, certain ion channels had already been demonstrated to be present in the heart with characteristics and properties usually attributed to the TREK channels (a subfamily of K2P c
Externí odkaz:
https://doaj.org/article/95503abd4162443fa44960125357ec68
Autor:
Susanne Rinné, Aytug K. Kiper, Constanze Schmidt, Beatriz Ortiz-Bonnin, Simone Zwiener, Guiscard Seebohm, Niels Decher
Publikováno v:
Cellular Physiology and Biochemistry, Vol 44, Iss 3, Pp 1024-1037 (2017)
Background/Aims: TASK channels belong to the two-pore-domain potassium (K2P) channel family. TASK-1 is discussed to contribute to chronic atrial fibrillation (AFib) and has been together with uncoupling protein 1 found as a marker protein of brown ad
Externí odkaz:
https://doaj.org/article/39747ae55a3242348190538d7dfbac3e