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Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels

Autor: Berke Türkaydin, Marcus Schewe, Elena Barbara Riel, Friederike Schulz, Johann Biedermann, Thomas Baukrowitz, Han Sun

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract The two-pore domain potassium (K2P) channels TREK-1 and TREK-2 link neuronal excitability to a variety of stimuli including mechanical force, lipids, temperature and phosphorylation. This regulation involves the C-terminus as a polymodal sti

Externí odkaz: https://doaj.org/article/5619ce0d50534cba80d1c6194a89ea85

Fluoxetine antagonizes the acute response of LPS: Blocks K2P channels.

Autor: Elliott ER; Department of Biology, University of Kentucky, Lexington 40506, KY, USA. Electronic address: erel222@uky.edu., Cooper RL; Department of Biology, University of Kentucky, Lexington 40506, KY, USA. Electronic address: RLCOOP1@email.uky.edu.

Publikováno v: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2024 Sep 20; Vol. 287, pp. 110045. Date of Electronic Publication: 2024 Sep 20.

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Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier

Autor: Hirosato Kanda, Koichi Noguchi, Yi Dai

Publikováno v: Molecular Brain, Vol 16, Iss 1, Pp 1-4 (2023)

Abstract Saltatory conduction is the propagation of action potentials along myelinated nerves, which enables fast propagation through the node of Ranvier. Recently, we demonstrated that K2P channels, TWIK-related K+ channel-1 (TREK-1), and TWIK-relat

Externí odkaz: https://doaj.org/article/eec9cc5d449c4c1fbcff3203c9e903a4