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c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway

Autor: David Hornby, Lizhi Liu, Weiming Xu

Publikováno v: Molecules, Vol 17, Iss 10, Pp 12086-12101 (2012)

Recent genetic studies have shown that PCSK9, one of the key genes in cholesterol metabolism, plays a critical role by controlling the level of low-density lipoprotein receptor. However, how PCSK9 mediates LDLR degradation is still unknown. By combin

Externí odkaz: https://doaj.org/article/49d00037fd634331b4b3bcea034112c1

Diffuse intrinsic pontine glioma cells are vulnerable to low intensity electric fields delivered by intratumoral modulation therapy

Autor: Matthew O. Hebb, Eugene Wong, Erin Iredale, Hu Xu, Andrew Deweyert, Susanne Schmid

Publikováno v: Journal of Neuro-Oncology
Anatomy and Cell Biology Publications

Introduction Diffuse intrinsic pontine glioma (DIPG) is a high fatality pediatric brain cancer without effective treatment. The field of electrotherapeutics offers new potential for other forms of glioma but the efficacy of this strategy has not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d53a9cfa2a16adb98ffac50b7e5ffd
https://doi.org/10.1007/s11060-019-03145-8

IGFBP-3: So Much More Than an IGF1/2 Binding Protein

Autor: Montserrat Marí

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 643-644 (2020)

Portal hypertension is a major consequence of the progression of chronic liver disease, leading to high morbidity and mortality.1 The prognosis of patients with portal hypertension has improved dramatically in the past decades mainly owing to a bette

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c8ec96d4c19ed089d9cc213c4d0fb2
https://pubmed.ncbi.nlm.nih.gov/32447051