Zobrazeno 1 - 10
of 258
pro vyhledávání: '"K18-hACE2"'
Autor:
Ji-Hun Lee, Eun-Seon Yoo, Na-Won Kim, Won-Yong Shim, Han-Bi Jeong, Dong-Hyun Kim, Young-Jun Park, Sun-Min Seo, Jun-Won Yun, Jun Won Park, Kang-Seuk Choi, Ho-Young Lee, Jun-Young Seo, Ki Taek Nam, Je Kyung Seong, Yang-Kyu Choi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Coronavirus disease-2019 (COVID-19), attributed to the severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2), has posed global health challenges since it first emerged in 2019, and its impact continues to persist. The neurotro
Externí odkaz:
https://doaj.org/article/9b4e8f09ba0b42bebfe4813960748baf
Autor:
Zhen Zhang, Li Zhou, Qianyun Liu, Yucheng Zheng, Xue Tan, Zhixiang Huang, Ming Guo, Xin Wang, Xianying Chen, Simeng Liang, Wenkang Li, Kun Song, Kun Yan, Jiali Li, Qiaohong Li, Yuzhen Zhang, Shimin Yang, Zeng Cai, Ming Dai, Qiaoyang Xian, Zheng-Li Shi, Ke Xu, Ke Lan, Yu Chen
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
Animal models of COVID-19 facilitate the development of vaccines and antivirals against SARS-CoV-2. The efficacy of antivirals or vaccines may differ in different animal models with varied degrees of disease. Here, we introduce a mouse model expressi
Externí odkaz:
https://doaj.org/article/fa17329035b44d72b792b36985b71803
Autor:
Aytül Gül, Sedef Erkunt Alak, Hüseyin Can, Muhammet Karakavuk, Gülay Korukluoğlu, Ayşe Başak Altaş, Ceren Gül, Tuğba Karakavuk, Ahmet Efe Köseoğlu, Hivda Ülbeği Polat, Hilal Yazıcı Malkoçoğlu, Arzu Taş Ekiz, İrem Abacı, Özge Aksoy, Hakan Enül, Cumhur Adıay, Serdar Uzar, Fahriye Saraç, Cemal Ün, Adnan Yüksel Gürüz, Ayşe Gülten Kantarcı, Hasan Akbaba, Gülşah Erel Akbaba, Habibe Yılmaz, Aysu Değirmenci Döşkaya, Meltem Taşbakan, Hüsnü Pullukçu, Ercüment Karasulu, Şaban Tekin, Mert Döşkaya
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Severe acute respiratory syndrome coronavirus 2 had devastating consequences for human health. Despite the introduction of several vaccines, COVID-19 continues to pose a serious health risk due to emerging variants of concern. DNA vaccines g
Externí odkaz:
https://doaj.org/article/70a1957a12804e069e8928eedb04be9a
Autor:
Lidia Sánchez-Morales, Néstor Porras, Teresa García-Seco, Marta Pérez-Sancho, Fátima Cruz, Blanca Chinchilla, Sandra Barroso-Arévalo, Marta Diaz-Frutos, Aránzazu Buendía, Inmaculada Moreno, Víctor Briones, María de los Ángeles Risalde, José de la Fuente, Ramón Juste, Joseba Garrido, Ana Balseiro, Christian Gortázar, Antonio Rodríguez-Bertos, Mercedes Domínguez, Lucas Domínguez
Publikováno v:
Veterinary Research, Vol 55, Iss 1, Pp 1-18 (2024)
Abstract In the wake of the COVID-19 pandemic caused by SARS-CoV-2, questions emerged about the potential effects of Bacillus Calmette-Guérin (BCG) vaccine on the immune response to SARS-CoV-2 infection, including the neurodegenerative diseases it m
Externí odkaz:
https://doaj.org/article/d1479fae9de64e50a9b822d845b11239
Publikováno v:
Immunity, Inflammation and Disease, Vol 12, Iss 8, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/cfb0b20c009343b096573b4954c83a5d
Autor:
Yasmin Silva-Santos, Roberta Liberato Pagni, Thais Helena Martins Gamon, Marcela Santiago Pacheco de Azevedo, Mônica Bielavsky, Maria Laura Goussain Darido, Danielle Bruna Leal de Oliveira, Edmarcia Elisa de Souza, Carsten Wrenger, Edson Luiz Durigon, Maria Cecília Rui Luvizotto, Hans Christian Ackerman, Claudio Romero Farias Marinho, Sabrina Epiphanio, Leonardo José Moura Carvalho
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
COVID-19 causes more severe and frequently fatal disease in patients with pre-existing comorbidities such as hypertension and heart disease. SARS-CoV-2 virus enters host cells through the angiotensin-converting enzyme 2 (ACE2), which is fundamental i
Externí odkaz:
https://doaj.org/article/0a80208c429c4258b038df8565cf4881
Autor:
María Ángeles Rodríguez-Hernández, Mercedes Baena-Bustos, David Carneros, Carola Zurita-Palomo, Pablo Muñoz-Pinillos, Jaime Millán, Francisco Javier Padillo, Cristian Smerdou, Cayetano von Kobbe, Stefan Rose-John, Matilde Bustos
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105132- (2024)
Summary: Background: SARS-CoV-2 infection is considered as a relapsing inflammatory process with a dysregulation of IL-6 signalling. Classic IL-6 signalling is thought to represent a defence mechanism against pathogens. In contrast, IL-6 trans-signal
Externí odkaz:
https://doaj.org/article/cb1a454d27374e47aa940a4799b66b43
Autor:
Sebenzile K. Myeni, Anouk A. Leijs, Peter J. Bredenbeek, Shessy Torres Morales, Marissa E. Linger, Cyrielle Fougeroux, Sophie van Zanen-Gerhardt, Serge A. L. Zander, Adam F. Sander, Marjolein Kikkert
Publikováno v:
Vaccines, Vol 12, Iss 7, p 766 (2024)
The SARS-CoV-2 pandemic and the emergence of novel virus variants have had a dramatic impact on public health and the world economy, underscoring the need for detailed studies that explore the high efficacy of additional vaccines in animal models. In
Externí odkaz:
https://doaj.org/article/d28bc8a871ee4f499192070d34b38ba9
Autor:
Seunghoon Choi, Jusung Lee, Suhyeon Kim, Youn Woo Lee, Gi-Cheon Kim, Seung-Min Hong, Se-Hee An, Hyuna Noh, Kyung Eun Kim, Dain On, Sang Gyu Lee, Hui Jeong Jang, Sung-Hee Kim, Jiseon Kim, Jung Seon Seo, Jeong Jin Kim, In Ho Park, Jooyeon Oh, Da-Jung Kim, Jong-Hwi Yoon, Sang-Hyuk Seok, Yu Jin Lee, Seo Yeon Kim, Young Been Kim, Ji-Yeon Hwang, Hyo-Jung Lee, Hong Bin Kim, Jun Won Park, Jun-Won Yun, Jeon-Soo Shin, Jun-Young Seo, Ki Taek Nam, Kang-Seuk Choi, Ho-Keun Kwon, Ho-Young Lee, Jong Kyoung Kim, Je Kyung Seong
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104932- (2024)
Summary: Background: The global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to approximately 500 million cases and 6 million deaths worldwide. Previous investigations into the pathophysiology of SARS-CoV-2
Externí odkaz:
https://doaj.org/article/f2f106e6b5e741e4b13b71bb0cdd0c4a
Autor:
Na Yun Lee, Youn Woo Lee, Seung-Min Hong, Dain On, Gyeong Min Yoon, See-He An, Ki Taek Nam, Jun-Young Seo, Jeon-Soo Shin, Yang-Kyu Choi, Seung Hyun Oh, Jun-Won Yun, Ho Young Lee, Kang-Seuk Choi, Je Kyung Seong, Jun Won Park
Publikováno v:
Laboratory Animal Research, Vol 39, Iss 1, Pp 1-7 (2023)
Abstract Background The Omicron variant has become the most prevalent SARS-CoV-2 variant. Omicron is known to induce milder lesions compared to the original Wuhan strain. Fatal infection of the Wuhan strain into the brain has been well documented in
Externí odkaz:
https://doaj.org/article/a80de1f53ebe4de3b13a5a95d4d67801