Zobrazeno 1 - 10
of 75
pro vyhledávání: '"K.Y. Jan"'
Autor:
Chien-Hung Chen, Balakrishnan Ramanathan, Tzyh-Chyuan Hour, K.Y. Jan, Yeong-Shiau Pu, Hong-Jen Yu
Publikováno v:
Cancer Research. 65:8455-8460
Paclitaxel, one of the most commonly prescribed chemotherapeutic agents, is active against a wide spectrum of human cancer. The mechanism of its cytotoxicity, however, remains controversial. Our results indicate that paclitaxel treatment increases le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f9896cc161b7b2051137f88a5827d3
https://doi.org/10.1158/0008-5472.can-05-1162
https://doi.org/10.1158/0008-5472.can-05-1162
Publikováno v:
Biological Trace Element Research. 59:1-11
The activities of DNA polymerization and DNA ligation in extract of Chinese hamster ovary cells were both stimulated by MgCl2. DNA polymerization was stimulated by MgCl2 above 0.25 mM, whereas, MgCl2 above 2 mM was required to stimulate DNA ligation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193e8e2a9659508c62bc1f54c39640ed
https://doi.org/10.1007/bf02783224
https://doi.org/10.1007/bf02783224
Publikováno v:
Toxicology and Applied Pharmacology. 144:171-176
The cogenotoxicity of Cd has been recognized. This effect may stem from Cd inhibition of DNA repair. We studied the effects of Cd on DNA repair of methyl methanesulfonate (MMS)-damaged Chinese hamster ovary cells (CHO-K1) by single-cell alkaline elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2c0b39c9ce0da390f37d3715660de9
https://doi.org/10.1006/taap.1997.8116
https://doi.org/10.1006/taap.1997.8116
Publikováno v:
Mutagenesis. 8:179-182
A background level of sister-chromatid exchange (SCE) is found in mammalian cells. However, in the somatic cells of Drosophila melanogaster, there was no spontaneous SCE if a minimum concentration of bromodeoxyuridine (BrdU) was used. In this communi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead480002a98fcf5bd6c946d81d667ea
https://doi.org/10.1093/mutage/8.3.179
https://doi.org/10.1093/mutage/8.3.179
Publikováno v:
International Journal of Radiation Biology. 61:57-62
It has previously been reported that chromosome aberrations induced by ultraviolet (UV) radiation can be enhanced by treatment with sodium arsenite for 24 h post-irradiation. Using synchronized CHO-K1 cells, it has now been established that cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270ff79805a0827a67cb44d005a0a270
https://doi.org/10.1080/09553009214550621
https://doi.org/10.1080/09553009214550621
Publikováno v:
Toxicology Letters. 51:81-90
Our present data show that postreatment with sodium arsenite has no effect on the cytotoxicity of bleomycin (BLM), a radiomimetic agent, in Chinese hamster ovary (CHO) cells, human skin fibroblasts, and HeLa cells. However, pretreatment with sodium a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4e9abc4a5c3075f57386c43878f70a
https://doi.org/10.1016/0378-4274(90)90227-d
https://doi.org/10.1016/0378-4274(90)90227-d
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 90(2)
Inorganic trivalent arsenicals are vicinal thiol-reacting agents, and dithiothreitol (DTT) is a well-known dithiol agent. Interestingly, both decreasing and increasing effects of DTT on arsenic trioxide-induced apoptosis have been reported. We now pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab4a6fdb57d1c9781116aa463efbd24
https://pubmed.ncbi.nlm.nih.gov/16421177
https://pubmed.ncbi.nlm.nih.gov/16421177
Publikováno v:
Mutation research. 615(1-2)
Drinking arsenic-contaminated water is associated with an increased risk of bladder cancer. Arsenate (iAs(V)), arsenite (iAs(III)), monomethylarsonous acid (MMA(III)), monomethylarsonic acid (MMA(V)), dimethylarsinous acid (DMA(III)), and dimethylars
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e955786af87010d5afb9b4fe3d8c470
https://pubmed.ncbi.nlm.nih.gov/17134727
https://pubmed.ncbi.nlm.nih.gov/17134727
Publikováno v:
Toxicology. 213(1-2)
Ultrafine titanium dioxide (TiO(2)) particles have been shown to exhibit strong cytotoxicity when exposed to UVA radiation, but are regarded as a biocompatible material in the absence of photoactivation. In contrast to this concept, the present resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd8eaa7475dd1d8368a0f9573b704a7
https://pubmed.ncbi.nlm.nih.gov/15970370
https://pubmed.ncbi.nlm.nih.gov/15970370
Publikováno v:
Free radical biologymedicine. 24(3)
Recent studies indicate that arsenic may generate reactive oxygen species to exert its toxicity. Because reactive oxygen species are known to induce poly(ADP-ribosylation), which is implicated in DNA repair, signal transduction, and apoptosis, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d143dc08a5daa7a43194a8dfbdb900b9
https://pubmed.ncbi.nlm.nih.gov/9438557
https://pubmed.ncbi.nlm.nih.gov/9438557