Zobrazeno 1 - 10
of 71
pro vyhledávání: '"K.R. Prabhakar"'
Autor:
Manoranjan Panda, Anandkumar Raichurkar, Neela Dinesh, Vinayak Hosagrahara, Naveen Kumar, K.R. Prabhakar, Suresh Rudrapatna, Gayathri Balakrishnan, Amit K. Gupta, Vasan K. Sambandamurthy, Karthikeyan Kandaswamy, Stefan Kavanagh, Ramanatha Saralaya, Lalit kumar Jena, Shridhar Narayanan, Suresh Solapure, Robert Nanduri, V. Balasubramanian, Meenakshi Mallya, Ashwini Narayan, Sowmya Bharath, Vijender Panduga, Vikas Shinde, Jitendar Reddy, Khisi Mdluili, Christopher B. Cooper, Parvinder Kaur, Shahul Hameed P, Sreevalli Sharma, Supreeth Guptha, Kakoli Mukherjee, Sudha Ravishankar, Radha Shandil, Pravin Iyer, Shankar D. Markad, Vasanthi Ramachandran, Takahiro Yano, Jyothi Bhat, Harvey Rubin, Subramanyam J. Tantry
Publikováno v:
MedChemComm. 7:1022-1032
The success of bedaquiline as an anti-tubercular agent for the treatment of multidrug-resistant tuberculosis has validated the ATP synthesis pathway and in particular ATP synthase as an attractive target. However, limitations associated with its use
Autor:
Swaminathan Rajagopalan, Jitendar Reddy, Vijender Panduga, K.R. Prabhakar, Naveen Kumar, Anand Anandkumar, Ragini Singh, Vasanthi Ramachandran, Swati Khandelwal, Santanu Datta, Narasimha Rao, Shridhar Narayanan, Suresh Solapure, Malancha Karmarkar, Radha Shandil, V. Balasubramanian, Ramanatha Saralaya, Robert Nanduri, Sreevalli Sharma
Publikováno v:
Antimicrobial Agents and Chemotherapy
There are currently 18 drug classes for the treatment of tuberculosis, including those in the development pipeline. An in silico simulation enabled combing the innumerably large search space to derive multidrug combinations. Through the use of ordina
Publikováno v:
Journal of Evolution of Medical and Dental Sciences. 4:16602-16604
Autor:
Sreevalli Sharma, Monalisa Chatterji, Ashwini Narayan, Sudha Ravishankar, Vasanthi Ramachandran, Vaishali Humnabadkar, Supreeth Guptha, Shahul Hameed, Praveena Manjrekar, Murugan Chinnapattu, K.R. Prabhakar
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:6165-6171
The Mur ligases play an essential role in the biosynthesis of bacterial peptidoglycan and hence are attractive antibacterial targets. A screen of the AstraZeneca compound library led to the identification of compound A, a pyrazolopyrimidine, as a pot
Autor:
K.R. Prabhakar, Mazhuvancherry Kesavan Unnikrishnan, Veeresh P. Veerapur, Punit Bansal, B.S. Thippeswamy, K.K. Srinivasan
Publikováno v:
Food Chemistry. 132:186-193
The present study was designed to investigate the effects of the ethanol extract of Ficus racemosa (FRE) on biochemical parameters in type 2-like diabetes, induced by a combination of standardised high-fat diet and low-dose streptozotocin (25mgkg(-1)
Autor:
Punit Bansal, K.I. Priyadarsini, B. Mishra, Veeresh P. Veerapur, K.R. Prabhakar, Mazhuvancherry Kesavan Unnikrishnan, B.S. Thippeswamy, S.D. Sneha, Pandian Nagakannan, B. D. Shivasharan
Publikováno v:
Biomedicine & Preventive Nutrition. 1:273-281
Ethanolic extract of Ficus racemosa [FRE] was subjected to bioactivity guided fractionation by steady state and kinetic methods using nanosecond pulse radiolysis and stopped-flow spectrophotometer. HPLC fingerprinting and other antioxidant studies re
Autor:
K.I. Priyadarsini, B. Mishra, Vipan K. Parihar, Veeresh P. Veerapur, K.R. Prabhakar, B. S. Satish Rao, K.K. Srinivasan, S. Ramakrishana, Mazhuvancherry Kesavan Unnikrishnan, Machendar Reddy Kandadi
Publikováno v:
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-Based Complementary and Alternative Medicine, Vol 6, Iss 3, Pp 317-324 (2009)
Evidence-Based Complementary and Alternative Medicine, Vol 6, Iss 3, Pp 317-324 (2009)
Ethanol extract (FRE) and water extract (FRW) ofFicus racemosa(family: Moraceae) were subjected to free radical scavenging both by steady state and time resolved methods such as nanosecond pulse radiolysis and stopped-flow spectrophotometric analyses
Autor:
K.R. Prabhakar, Chamallamudi Mallikajuna Rao, K.I. Priyadarsini, Mazhuvancherry Kesavan Unnikrishnan, Vipan K. Parihar, Veeresh P. Veerapur
Publikováno v:
European Journal of Pharmacology. 557:58-65
Anticlastogenic activity of morin was explored against whole body gamma radiation, at a dose rate of 1.66 Gy/min in Swiss albino mice pretreated intraperitoneal or orally. Pretreatment with morin 10, 25, 50, 75, 100, 125, and 150 mg/kg, i.p. delayed
Autor:
Shridhar Narayanan, Laura M. Sanz, Sreenivasaiah Menasinakai, Kevin Hickling, Abhishek Srivastava, Sapna Morayya, Anandkumar Raichurkar, Vikas Patil, Stefan Kavanagh, María Belén Jiménez-Díaz, Ramanatha Saralaya, Vijender Panduga, Gajanan Shanbag, Eknath V. Bellale, Lyn Rosenbrier-Ribeiro, K.R. Prabhakar, Anisha Ambady, David Waterson, Nikhil Rautela, Kannan Murugan, Pavithra Viswanath, Peter Warner, Pamela Magistrado, Pravin Iyer, Dyann F. Wirth, Jayashree Puttur, Krishna Koushik, Sowmya Bharath, Nilanjana Roy Choudhury, Philipp P. Henrich, Olivia Coburn-Flynn, Suresh Solapure, Radha Nandishaiah, Balachandra Bandodkar, Kakoli Mukherjee, María Santos Martínez, Suresh Rudrapatna, David A. Fidock, Shahul Hameed P, Vinayak Hosagrahara, Monalisa Chatterji, Vasan K. Sambandamurthy, V. Balasubramanian, Sudhir Landge, Jitendar Reddy, Robert E. McLaughlin, Amanda K. Lukens, Adam Jeston Dudley, Disha Awasthy
Publikováno v:
Nature Communications
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds,
Autor:
V.P. Veeresh, Mazhuvancherry Kesavan Unnikrishnan, M. Sudheer, K.I. Priyadarsini, R.B.S.S. Satish, K. Vipan, K.R. Prabhakar
Publikováno v:
Phytomedicine. 13:591-595
The whole plant aqueous extract of Coronopus didymus Linn. was fractionated on the basis of polarity and resulting fractions were evaluated for free radical scavenging ability. The most non-polar fraction (CDF1) was found to be more active than other