Zobrazeno 1 - 10
of 17
pro vyhledávání: '"K.R. Gurukumar"'
Autor:
Neerja Kaushik-Basu, Ş. Güniz Küçükgüzel, Oya Orun, Suna Özbaş-Turan, Amartya Basu, Sevil Aydin, Jülide Akbuğa, K.R. Gurukumar, Pınar Mega Tiber
Publikováno v:
Letters in Drug Design & Discovery. 11:121-131
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71796950fecbcf2fa3c92a38620d54e4
https://doi.org/10.2174/15701808113109990069
https://doi.org/10.2174/15701808113109990069
Autor:
Tanaji T. Talele, K.R. Gurukumar, İlkay Küçükgüzel, Daniel Brian Nichols, Esra Tatar, Amartya Basu, Neerja Kaushik-Basu, Gökhan Satılmış
Publikováno v:
European Journal of Medicinal Chemistry. 69:931-941
Hepatitis C virus (HCV) NS5B polymerase is an important and attractive target for the development of anti-HCV drugs. Here we report on the design, synthesis and evaluation of twenty-four novel allosteric inhibitors bearing the 4-thiazolidinone scaffo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e067b5691994061a413ddd1c699e6d
https://doi.org/10.1016/j.ejmech.2013.08.043
https://doi.org/10.1016/j.ejmech.2013.08.043
Autor:
K.R. Gurukumar, Amartya Basu, Jin-Ching Lee, Andriy G. Golub, Tanaji T. Talele, Volodymyr G. Bdzhola, Sergiy M. Yarmoluk, Daniel Brian Nichols, Neerja Kaushik-Basu, Yaroslav V. Bilokin
Publikováno v:
European Journal of Medicinal Chemistry. 58:258-264
Hepatitis C virus (HCV) NS5B polymerase is a key target for the development of anti-HCV drugs. Here we report on the identification of novel allosteric inhibitors of HCV NS5B through a combination of structure-based virtual screening and in vitro NS5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e254ba59234817d21f911b4e61a0f0
https://doi.org/10.1016/j.ejmech.2012.09.010
https://doi.org/10.1016/j.ejmech.2012.09.010
Autor:
Nikhil Khadtare, Payal Arora, Ramalingam Krishnan, Aaditya Bhatt, Tanaji T. Talele, Sanjai Kumar, K.R. Gurukumar, Dibyendu Dana, Neerja Kaushik-Basu, Bhargav A. Patel, Maulik R. Patel, Amartya Basu
Publikováno v:
Bioorganicmedicinal chemistry. 21(11)
Hepatitis C virus (HCV) NS5B polymerase is a key target for anti-HCV therapeutics development. Herein, we report the synthesis and in vitro evaluation of anti-NS5B polymerase activity of a molecular hybrid of our previously reported lead compounds 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3c993714cf8eb9a6bdf39860c7d9c0
https://pubmed.ncbi.nlm.nih.gov/23598249
https://pubmed.ncbi.nlm.nih.gov/23598249
Autor:
Neerja Kaushik-Basu, Rino Ragno, Benoît Joseph, Ira Musmuca, K.R. Gurukumar, Daniel Brian Nichols, Jin-Ching Lee, Frank Kozielski, Amartya Basu, Naoya Sakamoto, Guy Fournet
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2012, 49, pp.191-9. ⟨10.1016/j.ejmech.2012.01.010⟩
European Journal of Medicinal Chemistry, Elsevier, 2012, 49, pp.191-9. ⟨10.1016/j.ejmech.2012.01.010⟩
International audience; Structure-based studies led to the identification of a constrained derivative of S-trityl-l-cysteine (STLC) scaffold as a candidate inhibitor of hepatitis C virus (HCV) NS5B polymerase. A panel of STLC derivatives were synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff2240a0d007d58a3e3e8579845f6b9
https://europepmc.org/articles/PMC3288800/
https://europepmc.org/articles/PMC3288800/
Autor:
Neeraj Masand, K.R. Gurukumar, Satya P. Gupta, Maksim Chudayeu, Subeer Samanta, Neerja Kaushik-Basu, Vaishali M. Patil
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 8(4)
Hepatitis C virus (HCV) NS5B polymerase is the key replicating protein of the virus and thus an attractive target for drug development. Here we report on the synthesis and biological evaluation of a new series of benzimidazole derivatives as HCV NS5B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3897a452529860154671452c51fc4708
https://pubmed.ncbi.nlm.nih.gov/22530910
https://pubmed.ncbi.nlm.nih.gov/22530910
Autor:
Amartya Basu, Neerja Kaushik-Basu, Aaditya Bhatt, Maulik R. Patel, K.R. Gurukumar, Tanaji T. Talele
Hepatitis C virus (HCV) NS5B polymerase is a key target for anti-HCV therapeutics development. Here we report the synthesis and biological evaluation of a new series of α,γ-diketo acids (DKAs) as NS5B polymerase inhibitors. We initiated structure-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b8463b978ad524b4dcb4f7b2b0f0ab
https://europepmc.org/articles/PMC3208381/
https://europepmc.org/articles/PMC3208381/
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