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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin or 2,2′,4,4′,5,5′-hexachloro-biphenyl on vitamin K-dependent blood coagulation in male and female WAG/rij-rats

Autor: K.M. Fase, C.A. Bouwman, Cees Vermeer, Martin van den Berg, Willem Seinen, Edith Van Dam, Henk H.W. Thijssen, Janna G. Koppe

Publikováno v: Chemosphere. 38:489-505

Newborns are susceptible to hemorrhages (hemorrhagic disease of the newborn or HDN) due to vitamin K deficiency. Induction of cytochrome P450 in the fetal liver by maternal anticonvulsant therapy such as phenobarbital or phenytoin is considered to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a6e3c53a0b04c2aee18320e409d088
https://doi.org/10.1016/s0045-6535(98)00208-2

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Relative potencies of polychlorinated dibenzo-p-dioxins (PCDDS), dibenzofurans (PCDFS) and biphenyls (PCBS), for cytochrome P450 1A induction in the mirror carp (Cyprinus carpio)

Autor: Martin van den Berg, Martine E.J. van der Weiden, Willem Seinen, Luite Peter de Vries, K.M. Fase, Malin Celander

Publikováno v: Aquatic Toxicology. 29:163-182

Carp received a single i.p. dose of 2,3,7,8-TCDD, 2,3,7,8-TCDF, 1,2,3,7,8-PnCDD, 2,3,4,7,8-PnCDF, 1,2,3,6,7,8,-HxCDD, OCDF, OCDD, 2,3′,4,4′,5-PCB (PCB 118), 3,3′,4,4′,5-PCB (PCB126) or 2,2′,4,4′,5,5′-PCB (PCB 153). Four doses per congen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d70eb859b2810c8578db0c2716fcca
https://doi.org/10.1016/0166-445x(94)90066-3

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Synergistic effect of 2,2',4,4',5,5'-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic porphyrin levels in the rat

Autor: K.M. Fase, M. van den Berg, J. H. van der Kolk, A.P.J.M. van Birgelen, A. Brouwer, Willem Seinen, H. Poiger

Publikováno v: Environmental Health Perspectives

We studied the effect of polychlorinated biphenyls (PCBs) on hepatic porphyrin accumulation in female Sprague-Dawley rats by feeding them diets containing 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153), 2,3,3'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5607a4c9327146ee2c0a89a09f7538e2
https://pubmed.ncbi.nlm.nih.gov/8743444

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Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism: use in risk assessment

Autor: E.A. Smit, Jan H. Koeman, C.N. Groeneveld, A.P.J.M. van Birgelen, M. van den Berg, K.M. Fase, J. H. van der Kolk, I.M. Kampen, Abraham Brouwer, H. Poiger

Publikováno v: European journal of pharmacology. Environmental toxicology and pharmacology 293 (1995)
European journal of pharmacology. Environmental toxicology and pharmacology, 293, 77-85

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3',4,4',5-pentachlorobiphenyl (PCB 126), or 2,3,3',4,4',5-hexachlorobiphenyl (PCB 156) on thyroid hormone metabolism were studied in 13-week feeding studies in female Sprague-Dawley rats. The d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b114aee202d5ed6d79f8b3fd7ad71d
https://pubmed.ncbi.nlm.nih.gov/7672011

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Subchronic dose-response study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats

Autor: H. Poiger, K.M. Fase, M. van den Berg, I. Bol, Abraham Brouwer, A.P.J.M. van Birgelen, J. van der Kolk

Publikováno v: Organohalogen Compounds, 25, 207-212
Toxicology and Applied Pharmacology, 132, 1-13
Organohalogen Compounds 25 (1995)
Toxicology and Applied Pharmacology 132 (1995)

Toxic and biochemical potencies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were studied in a 13-week feeding study in female Sprague-Dawley rats. The diets were supplemented with 0, 0.2, 0.4, 0.7, 5, or 20 micrograms TCDD/kg diet. The estimated da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8b23f35537930d12da0d5cbf2b5182
https://pubmed.ncbi.nlm.nih.gov/7747272

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Toxic potency of 3,3',4,4',5-pentachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat

Autor: I. Bol, H. Poiger, Abraham Brouwer, J. H. van der Kolk, K.M. Fase, M. van den Berg, A.P.J.M. van Birgelen

Publikováno v: Toxicology and Applied Pharmacology 127 (1994)
Toxicology and Applied Pharmacology, 127, 209-221

Toxic and biochemical potencies of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) were studied relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a 13-week feeding study in female Sprague-Dawley rats. To study possible interactive effects the combi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85c793e409a7a1cbd78b12fa668c212
https://pubmed.ncbi.nlm.nih.gov/8048064

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Toxic potency of 2,3,3',4,4',5-hexachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat

Autor: A.P.J.M. Vanbirgelen, J. Vanderkolk, K.M. Fase, I. Bol, H. Poiger, M. Vandenberg, A. Brouwer

Publikováno v: Toxicology and applied pharmacology. 126(2)

Interactive effects on toxicity and biochemical parameters were studied between 2,3,3',4,4',5-hexachlorobiphenyl (PCB 156) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a 13-week feeding study of female Sprague-Dawley rats. The diets were supplem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2aa5281ce57dbdc494cdcf0114bb5c8
https://pubmed.ncbi.nlm.nih.gov/8209374

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