Zobrazeno 1 - 10
of 35
pro vyhledávání: '"K.M. Bray"'
Publikováno v:
Drug Development Research. 43:214-224
The aims of this study were to characterize the adenosine receptor subtype mediating inhibition of superoxide anion generation induced by N-formyl-methionyl-leucylphenylalanine (fMLP) in human neutrophils and to test the hypothesis that adenosine 3':
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a866f078f59efde43ae001093c48241
https://doi.org/10.1002/(sici)1098-2299(199804)43:4<214::aid-ddr5>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199804)43:4<214::aid-ddr5>3.0.co
Publikováno v:
Journal of Medicinal Chemistry. 36:2004-2010
The synthesis of N-cyano-N'-[1,1-dimethyl-[2,2,3,3-3H]propyl]-N"-(3- pyridinyl)guanidine, [3H]-15, is described. The utility of this tritiated radioligand in characterizing the interactions of potassium channel openers and blockers with their recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8610a868ba986af080ecc6bdc4ab1b
https://doi.org/10.1021/jm00066a009
https://doi.org/10.1021/jm00066a009
Autor:
K.M. Bray, Ulrich Quast
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 345:244-250
The effects of the K+ channel blockers tedisamil and glibenclamide on cromakalim- and minoxidil sulphate-induced 42K+ and 86Rb+ efflux and vasorelaxation in rat aorta, were investigated. In aortic strips preloaded with 42K+ or 86Rb+, cromakalim (1 mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d346950e74aefa0051d592c7552e2547
https://doi.org/10.1007/bf00165744
https://doi.org/10.1007/bf00165744
Autor:
Ulrich Quast, K.M. Bray
Publikováno v:
British Journal of Pharmacology. 102:585-594
1. The effects of acetylcholine and substance P on the efflux of 86Rb+ and 42K+ from rat aorta and pig coronary artery, respectively, were compared with those of the K+ channel opening agent, cromakalim. 2. In rat aorta preloaded with 86Rb+ and/or 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933c1b50c46f23b7cf37f7a5d37d94ce
https://doi.org/10.1111/j.1476-5381.1991.tb12217.x
https://doi.org/10.1111/j.1476-5381.1991.tb12217.x
Autor:
Gillian Edwards, K.M. Bray, T.J. Brown, D. T. Newgreen, Arthur H. Weston, J. Longmore, Susan Duty
Publikováno v:
British Journal of Pharmacology. 102:337-344
1. The effects of cromakalim on endothelium-denuded rabbit aortic strips were compared with those of the calcium (Ca2+) entry blocking agent, nifedipine. 2. Pre-incubation with cromakalim or nifedipine had no significant effect on the initial phasic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c03766a6967af384722d1af60a5b3cd
https://doi.org/10.1111/j.1476-5381.1991.tb12175.x
https://doi.org/10.1111/j.1476-5381.1991.tb12175.x
Autor:
J. Longmore, B. S. Brown, Susan Duty, D. T. Newgreen, P. B. Kay, A. D. McHarg, Arthur H. Weston, K.M. Bray, Gillian Edwards, J. S. Southerton
Publikováno v:
British Journal of Pharmacology. 100:605-613
1. The actions of diazoxide and minoxidil sulphate have been compared with those of cromakalim in rat aorta and portal vein. 2. Diazoxide and minoxidil sulphate hyperpolarized the rat portal vein in a similar manner to cromakalim. 3. Cromakalim, diaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a34565963a467df9000147a4c93971
https://doi.org/10.1111/j.1476-5381.1990.tb15854.x
https://doi.org/10.1111/j.1476-5381.1990.tb15854.x
Publikováno v:
Journal of Vascular Research. 27:306-313
Cromakalim, pinacidil, nicorandil, diazoxide and RP- 49356 belong to the class of drugs termed potassium channel openers. In rat portal vein diazoxide, like cromakalim, abolished spontaneous mechanical and electrical activity and in rat aorta caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a3881b429bb0f3adab1f09b94699c2
https://doi.org/10.1159/000158823
https://doi.org/10.1159/000158823
Autor:
Ulrich Quast, K.M. Bray
Publikováno v:
European Journal of Pharmacology. 200:163-165
Tedisamil, a blocker of cardiac K+ channels, potently inhibited cromakalim-induced 86Rb+ efflux from rat aorta with a pIC50 = 7.3, a value similar to that obtained with the sulphonylurea glibenclamide. However, tedisamil was approximately 30 times le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fb8999753d5b0c7164daddd1df4d64
https://doi.org/10.1016/0014-2999(91)90680-o
https://doi.org/10.1016/0014-2999(91)90680-o
1. Abstract Opening of plasmalemmal K + channels leads to cellular hyper-polarization which, in excitable tissues possessing voltage-dependent Ca 2+ channels, prevents the opening of such channels and thus prevents excitation. In the last few years a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16c8676383eb1ac067cd8a14307ac05f
https://doi.org/10.1016/b978-0-444-88931-7.50023-2
https://doi.org/10.1016/b978-0-444-88931-7.50023-2
Autor:
Ulrich Quast, K.M. Bray
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 344(3)
The effects of the K+ channel opening drugs minoxidil sulphate and cromakalim, on 42K+ and 86Rb+ efflux and on vasorelaxation in rat isolated aorta, were compared. In rat aortic rings precontracted with noradrenaline (100 nmol/l), minoxidil sulphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6c0ec1622d47af40224f6fa0e6b4a5
https://pubmed.ncbi.nlm.nih.gov/1961260
https://pubmed.ncbi.nlm.nih.gov/1961260