Zobrazeno 1 - 10
of 43
pro vyhledávání: '"K.L. Culley"'
Autor:
Tony Chen, Russell F. Warren, Laurianne Imbert, K.L. Culley, Suzanne A. Maher, Patrick E. Donnelly
Publikováno v:
Journal of Biomaterials Science, Polymer Edition. 30:215-232
The optimal solution for articular cartilage repair has not yet been identified, in part because of the challenges in achieving integration with the host. Coatings have the potential to transform the adhesive features of surfaces, but their applicati
Autor:
Mary B. Goldring, Justin Quinn, Darren A. Plumb, Cecilia Dragomir, E.B. Wondimu, Jun Chang, K.L. Culley, Miguel Otero
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
The E-74 like factor 3 (ELF3) is a transcription factor induced by inflammatory factors in various cell types, including chondrocytes. ELF3 levels are elevated in human cartilage from patients with osteoarthritis (OA), and ELF3 contributes to the IL-
Autor:
Lomeli Carpio Shull, Miguel Otero, Jennifer J. Westendorf, Lauren E. Ta, Marina Feigenson, Sanjeev Kakar, K.L. Culley, Elizabeth W. Bradley, Dana L. Begun, Mary B. Goldring, Soyun M. Hwang
Publikováno v:
Journal of Orthopaedic Research®. 36:1487-1497
Phlpp protein phosphatases are abnormally abundant within human osteoarthritic articular chondrocytes and may contribute to the development of osteoarthritis. Mice lacking Phlpp1 were previously shown to be resistant to post-traumatic osteoarthritis.
Autor:
Kazuo Kaneko, I. Futami, Eri Arikawa-Hirasawa, Miguel Otero, K.L. Culley, Shinnosuke Hada, Risa Nonaka, H. Kaneko, Ryo Sadatsuki, Mayuko Kinoshita, Yoshihiko Yamada, Mary B. Goldring, Muneaki Ishijima
Publikováno v:
Journal of Orthopaedic Research. 35:837-846
We previously reported that perlecan, a heparan-sulfate proteoglycan (Hspg2), expressed in the synovium at the cartilage-synovial junction, is required for osteophyte formation in knee osteoarthritis. To examine the mechanism underlying this process,
Autor:
Sarah J. B. Snelling, L. Le, Tracey E. Swingler, Rose K Davidson, Ian M. Clark, K.L. Culley, Andrew Carr, Matt J. Barter, Andrew Price
Publikováno v:
Osteoarthritis and Cartilage
Summary Objective Dickkopf-3 (Dkk3) is a non-canonical member of the Dkk family of Wnt antagonists and its upregulation has been reported in microarray analysis of cartilage from mouse models of osteoarthritis (OA). In this study we assessed Dkk3 exp
Publikováno v:
Cartilage ISBN: 9783319458014
Osteoarthritis (OA) is the most common joint disorder and is a leading cause of disability in the adult population. It is now appreciated that all components of the joint, including the cartilage, calcified cartilage, synovial joint lining, and peria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b84c72f2d508592b0d0804b9f1f5ed4e
https://doi.org/10.1007/978-3-319-45803-8_1
https://doi.org/10.1007/978-3-319-45803-8_1
Autor:
Andrew D. Rowan, Simon T. Donell, Auriane P. M. Destrument, K.L. Culley, Tracey E. Swingler, Steve Fenwick, Wang Hui, Jenny L. Scott, Ian M. Clark, David Young, Matt J. Barter, Rose K Davidson
Publikováno v:
Arthritis & Rheumatism. 65:1822-1830
Objective To examine the ability of a broad-spectrum histone deacetylase (HDAC) inhibitor to protect cartilage in vivo, and to explore the effects of class-selective HDAC inhibitors and small interfering RNA (siRNA)–induced knockdown of HDACs on me
Autor:
Karim El Hachem, Ko Hashimoto, K.L. Culley, Kaneyuki Tsuchimochi, Hiroshi Asahara, E.B. Wondimu, Haibing Peng, Miguel Otero, Mary B. Goldring, Justin Quinn
Publikováno v:
Connective tissue research. 58(1)
We showed previously that E74-like factor 3 (ELF3) protein levels are increased in osteoarthritic (OA) cartilage, that ELF3 accounts for inflammatory cytokine-driven MMP13 gene expression, and that, upon induction by interleukin-1β, ELF3 binds to th
Autor:
Kosei Ijiri, Kaneyuki Tsuchimochi, H. Peng, Mary B. Goldring, M. Otero, E.B. Wondimu, K.L. Culley
Publikováno v:
Osteoarthritis and Cartilage. 24