Zobrazeno 1 - 10
of 76
pro vyhledávání: '"K.J. Watling"'
Autor:
Fu-Zon Chung, Geoffrey N. Woodruff, Zarina Madden, Robert D. Pinnock, N. Suman-Chauhan, K.J. Watling, Steven Guard, Pauline Grimson
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 269:65-72
Human tachykinin NK3 receptors expressed in Chinese hamster ovary (CHO-K1) cells were characterised using the novel radioligand [125I]iodohistidyl,[MePhe7]neurokinin B ([125I][MePhe7]neurokinin B). [125I][MePhe7]neurokinin B was shown to label human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0355774befd538976b230fdc1dc8f6e
https://doi.org/10.1016/0922-4106(94)90027-2
https://doi.org/10.1016/0922-4106(94)90027-2
Autor:
Geoffery N. Woodruff, John O'Toole, John Hughes, David C. Rees, Michael Higginbottom, Steven Boyle, William Howson, David Christopher Horwell, Kevan Martin, Martyn Clive Pritchard, Steven Guard, Alexander T. McKnight, K.J. Watling, Edward Roberts, Jenny Raphy
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:357-370
The rational design of a non-peptide tachykinin NK 1 receptor antagonist, [(2-benzofuran)-CH 2 OCO]-( R )-α-MeTrp-( S )-NHCH(CH 3 )Ph ( 28 , PD 154075) is described. Compound 28 has a K i = 9 and 0.35 nM for the NK 1 receptor binding site in guinea-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff10f38b604afb8e32f570d530a3f43
https://doi.org/10.1016/s0968-0896(00)82192-6
https://doi.org/10.1016/s0968-0896(00)82192-6
Publikováno v:
Biochemical Society Transactions. 22:118-122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd22033d7135e5ef957ad75ccb98348d
https://doi.org/10.1042/bst0220118
https://doi.org/10.1042/bst0220118
Publikováno v:
European Journal of Pharmacology. 240:177-184
The pharmacological profile of [125I][Tyr4]bombesin binding to gastrin-releasing peptide- and neuromedin B-preferring sites has been investigated in rat cerebral cortex and olfactory bulb membranes, respectively. [125I][Tyr4]bombesin specific binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943e928ee6ceaabec7ffeddb12be4568
https://doi.org/10.1016/0014-2999(93)90896-p
https://doi.org/10.1016/0014-2999(93)90896-p
Publikováno v:
European Journal of Pharmacology. 232:287-290
The pharmacological profile of NK 2 binding sites has been characterized in homogenates of rabbit urinary bladder and compared with that present in homogenates of hamster bladder. In both species, [ 125 I]neurokinin A-specific binding to urinary blad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eb32dcc27e704957576afae95b6da3
https://doi.org/10.1016/0014-2999(93)90786-h
https://doi.org/10.1016/0014-2999(93)90786-h
Autor:
K.J. Watling, James E. Krause
Publikováno v:
Trends in Pharmacological Sciences. 14:81-84
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd26050791599af5b50774c2e2cae6a1
https://doi.org/10.1016/0165-6147(93)90067-t
https://doi.org/10.1016/0165-6147(93)90067-t
Publikováno v:
British Journal of Pharmacology. 101:1001-1005
1. Tachykinin-stimulated inositol phospholipid hydrolysis was examined in slices of rat parotid gland, hamster urinary bladder and guinea-pig ileum longitudinal muscle. 2. In the presence of lithium, substance P and other naturally-occurring and synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3af9e5c73eec00f98402ac491c0867
https://doi.org/10.1111/j.1476-5381.1990.tb14196.x
https://doi.org/10.1111/j.1476-5381.1990.tb14196.x
Autor:
K.J. Watling, R. Franks, R. Zarnegar, Rémi Quirion, Steven Guard, D. Pain, James E. Krause, Yasuo Takeda
Publikováno v:
Regulatory Peptides. 46:311-313
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ee936a1666f34a1d926b4601a67f3a
https://doi.org/10.1016/0167-0115(93)90070-o
https://doi.org/10.1016/0167-0115(93)90070-o
Autor:
M. A. Vartanian, Fu-Zon Chung, Steven Guard, Geoffrey N. Woodruff, Dale L. Oxender, K.J. Watling, Lan-Hsin Wu
Publikováno v:
Biochemical and biophysical research communications. 198(3)
SR 48968, a non-peptide tachykinin NK 2 receptor antagonist, has been shown to possess sub-micromolar affinity for NK 3 receptors present in the guinea pig. In the present study, we have compared the binding affinities of SR 48968 to the cloned human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d911c1ca5f632e9b090d19d27c2afa
https://pubmed.ncbi.nlm.nih.gov/8117304
https://pubmed.ncbi.nlm.nih.gov/8117304
Autor:
William Howson, J. Hodgson, John Hughes, K. Martin, Alexander T. McKnight, Martyn Clive Pritchard, S. J. Boyle, Steven Guard, K.J. Watling, Geoffrey N. Woodruff, David Christopher Horwell
Publikováno v:
Bioorganicmedicinal chemistry. 2(2)
The rational discovery of a high affinity NK2 receptor antagonist is described utilizing a general strategy for peptoid design. The contribution to NK2 receptor binding affinity for each amino acid of the hexapeptide 'minimum fragment': Leu-Met-Gln-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d69e51a9f910b531663707f9c3b12f
https://pubmed.ncbi.nlm.nih.gov/7922121
https://pubmed.ncbi.nlm.nih.gov/7922121