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pro vyhledávání: '"K.A.T. Naipal"'
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Akademický článek
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Autor:
Winand N.M. Dinjens, Titia G. Meijer, Dik C. van Gent, Hein F.B.M. Sleddens, Harmen J.G. van de Werken, Michael A. den Bakker, Carolien H.M. van Deurzen, Anieta M. Sieuwerts, Job van Riet, T. Dorine den Toom, John W.M. Martens, Agnes Jager, Marcel Smid, Petra M. Nederlof, K.A.T. Naipal, Nicole S. Verkaik, Roland Kanaar, Esther H. Lips, H.J. Dubbink
Publikováno v:
Clinical Cancer Research, 24(24), 6277-6287. American Association for Cancer Research Inc.
Purpose: Tumors of germline BRCA1/2 mutated carriers show homologous recombination (HR) deficiency (HRD), resulting in impaired DNA double-strand break (DSB) repair and high sensitivity to PARP inhibitors. Although this therapy is expected to be effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350aea2a0b0a0612f9695298bbd8e905
https://doi.org/10.1158/1078-0432.ccr-18-0063
https://doi.org/10.1158/1078-0432.ccr-18-0063
Autor:
Gerda M. Verduijn, Martine Franckena, Agnes Jager, Berina Eppink, K.A.T. Naipal, Gerard C. van Rhoon, Hanny Odijk, Jose A. Hardillo, Jan C. Drooger, Nathalie van den Tempel, Helena C. van Doorn, Dineke H P M Smedts, Roland Kanaar, Dik C. van Gent, Joost L. Boormans, Anja Raams, Netteke van Holthe
Publikováno v:
International Journal of Hyperthermia, 34(4), 407-414. Informa Healthcare
Purpose: Hyperthermia (40–44 °C) effectively sensitises tumours to radiotherapy by locally altering tumour biology. One of the effects of heat at the cellular level is inhibition of DNA repair by homologous recombination via degradation of the BRC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169f2db6a3942defc53ab3acca98f80f
https://pure.eur.nl/en/publications/ca0b94b1-cb44-45dc-8804-b429864143c9
https://pure.eur.nl/en/publications/ca0b94b1-cb44-45dc-8804-b429864143c9
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Future Science OA, 3(2):Fso190. Future Medicine Ltd.
Future Science OA
Future Science OA
Optimal patient stratification is of utmost importance in the era of personalized medicine. Prediction of individual treatment responses by functional ex vivo assays requires model systems derived from viable tumor samples, which should closely resem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173325eee3eb2366e095231516a43ccf
https://pure.eur.nl/en/publications/c388c1f8-2b76-43ce-8d86-825352b5de3c
https://pure.eur.nl/en/publications/c388c1f8-2b76-43ce-8d86-825352b5de3c
Autor:
N J F van den Broek, Judith Campisi, D Putavet, D C van Gent, Boudewijn M.T. Burgering, P L J de Keizer, J.H.J. Hoeijmakers, M P Baar, Arjan B. Brenkman, K.A.T. Naipal, Flore Kruiswijk, Renuka Sivapatham, P.J. van der Spek, Wim H. J. Kruit, Sebastian C. Hasenfuss
Publikováno v:
Oncogene, 35(17), 2166-2177. Nature Publishing Group
Oncogene
Oncogene, 35(17), 2166. Nature Publishing Group
Oncogene
Oncogene, 35(17), 2166. Nature Publishing Group
Melanoma is the most lethal form of skin cancer and successful treatment of metastatic melanoma remains challenging. BRAF/MEK inhibitors only show a temporary benefit due to rapid occurrence of resistance, whereas immunotherapy is mainly effective in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d159499dd1b43e3fd7972e28f4a7040
https://pure.eur.nl/en/publications/65ad3aa2-05f7-42e8-9673-cab4e71557c6
https://pure.eur.nl/en/publications/65ad3aa2-05f7-42e8-9673-cab4e71557c6
Autor:
Martin J. van den Bent, Dik C. van Gent, Lotte M. E. Berghauser Pont, Martine L.M. Lamfers, Roland Kanaar, K.A.T. Naipal, Subramanian Venkatesan, Sieger Leenstra, Clemens M F Dirven, Jenneke Kloezeman
Publikováno v:
Cancer Letters, 356(2), 525-535. Elsevier Ireland Ltd
HDAC inhibitors have radiosensitizing effects in established cancer cell lines. This study was conducted to compare the efficacy of SAHA, LBH589, Valproic Acid (VPA), MS275 and Scriptaid in the patient-derived glioblastoma model. In more detail, SAHA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d70eb165f3799f37f4c9f41edc8e03c
https://pubmed.ncbi.nlm.nih.gov/25305451
https://pubmed.ncbi.nlm.nih.gov/25305451
Autor:
Roland Kanaar, Nicole S. Verkaik, D C van Gent, K.A.T. Naipal, J.H.J. Hoeijmakers, Titia G. Meijer, C.H.M. van Deurzen, A. Jager
Publikováno v:
European Journal of Cancer. 61:S21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcbbbce7d41330a7e452251a953c6ae6
https://doi.org/10.1016/s0959-8049(16)61062-6
https://doi.org/10.1016/s0959-8049(16)61062-6
Autor:
K.A.T. Naipal, G.J.L.H. Van Leenders, D.C. van Gent, Roland Kanaar, Joost L. Boormans, Anja Raams
Publikováno v:
European Urology Supplements. 15:e937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f5cd5650f954fa09977b5b4ce0c2f36
https://doi.org/10.1016/s1569-9056(16)60939-9
https://doi.org/10.1016/s1569-9056(16)60939-9