Výsledky vyhledávání

Preterm birth does not affect bone mineral density in young adults

Autor: Sandra W K de Kort, Ralph W. J. Leunissen, Ruben H. Willemsen, Petra E. Breukhoven, Anita C. S. Hokken-Koelega

Publikováno v: European Journal of Endocrinology, 164, 133-138. Bioscientifica Ltd

ObjectivePrevious studies showed conflicting data on the effect of prematurity on bone mineral density (BMD) in infants and children. Only a few studies investigated the long-term effects of prematurity on BMD in early adulthood. The objective of our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d2556db65b2b2abdba62f8a5da9842
https://doi.org/10.1530/eje-10-0573

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ORIGINAL ARTICLE: Should short children born small for gestational age with a distance to target height <1 standard deviation score be excluded from growth hormone treatment?

Autor: Annemieke J. Lem, Sandra W K de Kort, Anita C. S. Hokken-Koelega, Maria A. J. de Ridder

Publikováno v: Clinical Endocrinology. 73:355-360

Summary Context The criteria for starting growth hormone (GH), an approved treatment for short children born small for gestational age (SGA), differ between Europe and the USA. One European requirement for starting GH, a distance to target height (DT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e276c17c5f86ee36d303a811d3a275a7
https://doi.org/10.1111/j.1365-2265.2010.03833.x

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The PPAR-y Pro12Ala polymorphisms associated with weight gain during GH-treatment in short children born small for gestationa age

Autor: Sandra W K de Kort, Anita C. S. Hokken-Koelega

Publikováno v: European Journal of Endocrinology, 162, 49-52. Bioscientifica Ltd

ContextShort children born small for gestational age (SGA) have a lean phenotype with lower insulin sensitivity and higher blood pressure. GH treatment results in weight gain, and a decrease in blood pressure and insulin sensitivity. However, not all

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https://doi.org/10.1530/eje-09-0631

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Interactions between TCF7L2 genotype and growth hormone-induced changes in glucose homeostasis in small for gestational age children

Autor: Sandra W K de Kort, Anita C. S. Hokken-Koelega, Dennis O. Mook-Kanamori, Vincent W. V. Jaddoe

Publikováno v: Clinical Endocrinology. 72:47-52

Summary Context The Transcription factor 7-like 2 (TCF7L2) rs7903146 gene polymorphism has been associated with risk of developing type 2 diabetes mellitus (DM), possibly by decreasing insulin secretion. Small for gestational age (SGA) birth has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c6845df6dcaa305c9b2624fb95aa2f1
https://doi.org/10.1111/j.1365-2265.2009.03635.x

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Serum insulin-like growth factor-Binding protein-2 levels and metabolic and cardiovascular risk factors in young adults and children born small for gestational age

Autor: Ad G. M. van de Sande, Anita C. S. Hokken-Koelega, Sandra W K de Kort, Jaap van Doorn, Ralph W. J. Leunissen

Publikováno v: Journal of Clinical Endocrinology and Metabolism, 95(2), 864-871. Endocrine Society

IGF binding protein (IGFBP)-2 might protect against cardiovascular disease. Small for gestational age (SGA) birth could be associated with a higher risk for type 2 diabetes mellitus and cardiovascular disease in later life. No data are available on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19fa90fd9a74427245fa1a199cfd2fd
https://hdl.handle.net/1765/27345

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Phenotype-genotype correlation in a familial IGF1R microdeletion case

Autor: Lutgarde C.P. Govaerts, H.J. Eussen, R J Odink, S W K de Kort, Carine Wouters, Danielle Veenma, A. de Klein, Anita C. S. Hokken-Koelega

Publikováno v: Journal of Medical Genetics, 47, 492-498. BMJ Publishing Group

Background: IGF1R (Insulin-Like Growth Factor 1 Receptor) haploinsufficiency is a rare event causing difficulties in defining clear genotype-phenotype correlations, although short stature is its’ well-established hallmark. Several pure 15q26 monoso

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https://doi.org/10.1136/jmg.2009.070730

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Does preterm birth influence the response to growth hormone treatment in short, small for gestational age children?

Autor: Ruben H. Willemsen, Anita C. S. Hokken-Koelega, Sandra W K de Kort, Danielle C. M. van der Kaay, Hugo J. Duivenvoorden

Publikováno v: Clinical Endocrinology, 70, 582-587. Wiley-Blackwell Publishing Ltd

Objective To investigate whether prematurity has an independent influence on the response to GH treatment in short, small for gestational age (SGA) children. Design A longitudinal 3-year GH study. Patients A total of 392 prepubertal non-GH-deficient,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a22b195926ea9efd26a019c3706634
https://doi.org/10.1111/j.1365-2265.2008.03484.x

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Insulin-Like Growth Factor-Binding Protein-1: Serum Levels, Promoter Polymorphism, and Associations with Components of the Metabolic Syndrome in Short Subjects Born Small for Gestational Age

Autor: Ralph W. J. Leunissen, Cheri Deal, Wietske A. Ester, Danielle C. M. van der Kaay, Anita C. S. Hokken-Koelega, Sandra W K de Kort, Jean Paquette, Jaap van Doorn, Ruben H. Willemsen

Publikováno v: Endocrine Research, 94(4), 1386-1392. Informa Healthcare

IGF binding protein (IGFBP)-1 is the only acute regulator of IGF-I bioavailability. Its production is suppressed by insulin, and low levels are associated with hyperinsulinemia and cardiovascular disease risk in adults. Data on IGFBP-1 levels in shor

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https://doi.org/10.1210/jc.2008-1430

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Genetic and epigeneti variability in the gene for IGFBP-3 (IGFBP3): Correlation with serum IGFBP-3 levels and growth in short children born small for gestational age

Autor: D.C.M. van der Kaay, Cheri Deal, S. W. K. de Kort, Jean Paquette, Ralph W. J. Leunissen, Wietske A. Ester, Anita C. S. Hokken-Koelega, A.E.J. Hendriks, Ruben H. Willemsen

Publikováno v: Growth Hormone and IGF Research, 19, 198-205. Elsevier Ltd.

Context IGF-I and IGFBP-3 play a central role in fetal and postnatal growth and levels are low in short SGA children. The -202 A/C and -185 C/T SNPs are located near elements involved in directing IGFBP3 promoter activity and expression. Changes in p

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https://pure.eur.nl/en/publications/720807d5-1fca-4e94-ac15-feb14b35bd30

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Cardiovasculair risk factors in parents of short children born small for gestational age

Autor: Marije van Dijk, Ruben H. Willemsen, Anita C. S. Hokken-Koelega, Yolanda B. de Rijke, Lucie Viet, Wietske A. Ester, Sandra W K de Kort

Publikováno v: Pediatric Research, 64(1), 91-96. Lippincott Williams & Wilkins

Small for gestational age (SGA) children have a higher prevalence of cardiovascular risk factors at a young age. It is not known whether this increased risk is caused by their size at birth, a familial predisposition for cardiovascular disease or sma

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https://doi.org/10.1203/PDR.0b013e3181732922

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