Zobrazeno 1 - 10
of 182
pro vyhledávání: '"K. Wareham"'
Autor:
Maximilian J. Garcia, Monica S. Morales, Tzushan S. Yang, Joseph Holden, Olivia L. Bossardet, Samuel A. Palmer, Marvarakumari Jhala, Stephen Priest, Neeraj Namburu, Nolan Beatty, Sariah E. D’Empaire Salomon, Jordan Vancel, Lauren K. Wareham, Dolly Ann Padovani-Claudio
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-22 (2024)
Abstract The family of pro-inflammatory and pro-angiogenic chemokines including Interleukin-8 (IL-8, aka CXCL8) and its homologues (CXCL1,2,3,5,6, and 7) exhibit promiscuous binding and activation of several G-protein-coupled receptors (i.e., CXCR2,
Externí odkaz:
https://doaj.org/article/fd412cd117e540968156ef8420fb5413
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract The extracellular matrix is a richly bioactive composition of substrates that provides biophysical stability, facilitates intercellular signaling, and both reflects and governs the physiological status of the local microenvironment. The matr
Externí odkaz:
https://doaj.org/article/a207ceef47b64a0f8c77cf84dfe821bd
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Astrocytes are important regulators of blood flow and play a key role in the response to injury and disease in the central nervous system (CNS). Despite having an understanding that structural changes to these cells have consequences for local neurov
Externí odkaz:
https://doaj.org/article/23fcaeeaeea84c37ab2871b516840550
Autor:
Lauren K. Wareham, Joseph M. Holden, Olivia L. Bossardet, Robert O. Baratta, Brian J. Del Buono, Eric Schlumpf, David J. Calkins
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
The intraepithelial sub-basal nerve plexus of the cornea is characterized by a central swirl of nerve processes that terminate between the apical cells of the epithelium. This plexus is a critical component of maintaining homeostatic function of the
Externí odkaz:
https://doaj.org/article/9da9d9f7e3c24a5da3069e7c52b07094
Autor:
Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, M. Valeria Canto-Soler, John G. Flanagan, Preeti Subramanian, Sharyn Rossi, Thomas Brunner, Diane E. Bovenkamp, David J. Calkins
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss em
Externí odkaz:
https://doaj.org/article/c304792ddb214075a9d068c15e1e5d12
Autor:
Lauren K. Wareham, John Kuchtey, Hang-Jing Wu, Evan Krystofiak, Yusheng Wu, Cynthia A. Reinhart-King, Rachel W. Kuchtey
Publikováno v:
Matrix Biology Plus, Vol 16, Iss , Pp 100120- (2022)
Lysyl oxidase-like 1 encoded by the LOXL1 gene is a member of the lysyl oxidase family of enzymes that are important in the maintenance of extracellular matrix (ECM)-rich tissue. LOXL1 is important for proper elastic fiber formation and mice lacking
Externí odkaz:
https://doaj.org/article/7c4668119b6448e9a94d441e342eee23
Autor:
Lauren K. Wareham, Amy E. Whitener, Hang-Jing Wu, Shu-Yu Wu, Hassane S. Mchaourab, Douglas P. Mortlock, Rachel W. Kuchtey, John Kuchtey
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Although mutations in ADAMTS10 have long been known to cause autosomal recessive Weill-Marchesani Syndrome which is characterized by short stature and ocular abnormalities, more recent work has shown that certain mutations in ADAMTS10 cause glaucoma
Externí odkaz:
https://doaj.org/article/a581c4471555490e81ea1730455c0abd
Autor:
Joseph M Holden, Lauren K Wareham
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 6, Pp 1267-1268 (2023)
Externí odkaz:
https://doaj.org/article/e18afb1e60eb4c9488651bfd9d3c77bb
cGMP Signaling in the Neurovascular Unit—Implications for Retinal Ganglion Cell Survival in Glaucoma
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1671 (2022)
Glaucoma is a progressive age-related disease of the visual system and the leading cause of irreversible blindness worldwide. Currently, intraocular pressure (IOP) is the only modifiable risk factor for the disease, but even as IOP is lowered, the pa
Externí odkaz:
https://doaj.org/article/5948df5d70f7435388b58d64f2c24888
Autor:
Lauren K. Wareham, Franklin D. Echevarria, Jennifer L. Sousa, Danielle O. Konlian, Gabrielle Dallas, Cathryn R. Formichella, Priya Sankaran, Peter J. Goralski, Jenna R. Gustafson, Rebecca M. Sappington
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103141- (2021)
Summary: The interleukin-6 (IL-6) family of cytokines and its downstream effector, STAT3, are important mediators of neuronal health, repair, and disease throughout the CNS, including the visual system. Here, we elucidate a transcription-independent
Externí odkaz:
https://doaj.org/article/b63bd7395b34419184036396f2f520ab