Zobrazeno 1 - 10
of 27
pro vyhledávání: '"K. W. Riggs"'
Publikováno v:
Laboratory Animals. 34:386-398
The use of pigs as research animals in survival surgery has increased greatly in the last 15 years. Personnel conducting pig research have been hampered by a lack of proven long-acting analgesics for treatment of surgical pain of longer duration, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a0321f837d0b0191ca0664d6619c8b
https://doi.org/10.1258/002367700780387750
https://doi.org/10.1258/002367700780387750
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 75:959-968
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0dc346ad4946cb0680a4cf68d3abd8
https://doi.org/10.1139/y97-120
https://doi.org/10.1139/y97-120
Autor:
K W Riggs, Jiaojiao Zheng, Dan W. Rurak, S. K. Panesar, J. D. Gordon, Frank S. Abbott, Dienchen Yu
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 666:269-281
An improved method for the quantitative determination of valproic acid (VPA) and sixteen of its metabolites has been developed using gas chromatography-mass spectrometry with selected-ion monitoring. The method is applicable to serum or urine and all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d43756d1b3af5ccc5e1ba4ada2b4af8
https://doi.org/10.1016/0378-4347(94)00585-s
https://doi.org/10.1016/0378-4347(94)00585-s
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
Dose-dependent pharmacokinetics and metabolism of valproic acid (VPA) were studied in newborn and adult sheep to assess age-related differences in plasma protein binding and metabolic elimination. Newborn lambs received either a 10- (n = 8), 50- (n =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29d93e79e208e70e2073214e6c221276
https://pubmed.ncbi.nlm.nih.gov/11302932
https://pubmed.ncbi.nlm.nih.gov/11302932
Autor:
K J, McKeown, J R, Challis, C, Small, L, Adamson, A D, Bocking, M, Fraser, D, Rurak, K W, Riggs, S J, Lye
Publikováno v:
Biology of reproduction. 63(6)
Term and preterm labor are associated with increased fetal hypothalamic-pituitary-adrenal (HPA) activation and synthesis of prostaglandins (PGs) generated through the increased expression of prostaglandin H synthase-II (PGHS-II) in the placenta. Inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06349725f87064adb78eeba51c8bec22
https://pubmed.ncbi.nlm.nih.gov/11090463
https://pubmed.ncbi.nlm.nih.gov/11090463
Publikováno v:
Journal of pharmaceutical sciences. 89(10)
The developmental disposition of diphenhydramine (DPHM) and its metabolites, diphenylmethoxyacetic acid (DPMA) and DPHM-N-oxide (DPHMNO), was investigated in postnatal lambs. Lambs received a DPHM intravenous (iv) bolus 15 days (Group A; n = 5) or 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6466a7a5000f0cbc1aeffdce940222ac
https://pubmed.ncbi.nlm.nih.gov/10980511
https://pubmed.ncbi.nlm.nih.gov/10980511
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(8)
The ontogeny of valproic acid (VPA) disposition and metabolism was investigated in developing lambs and adult sheep (Dorset or Suffolk breed). Specifically, we wished to investigate the role of glucuronidation and beta-oxidation on VPA elimination du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14ffc9f6175f20b52d549bbdb4d3c668
https://pubmed.ncbi.nlm.nih.gov/10901700
https://pubmed.ncbi.nlm.nih.gov/10901700
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(7)
Metabolism and renal excretion of valproic acid (VPA) were examined in maternal, fetal, and newborn sheep to identify the underlying reasons for the previously observed reduced VPA clearance in newborn lambs. Plasma and urine from VPA infusion studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::041195c06e5c5976687134d3ad141b77
https://pubmed.ncbi.nlm.nih.gov/10859160
https://pubmed.ncbi.nlm.nih.gov/10859160
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(7)
Separate 24-h maternal and fetal infusions of valproic acid (VPA) were administered to five pregnant sheep at 125 to 138 days gestation (term approximately 145 days) to determine maternal-fetal disposition. The pharmacokinetics of VPA were also inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d4daaae5af8380a6a05179c70515773
https://pubmed.ncbi.nlm.nih.gov/10859159
https://pubmed.ncbi.nlm.nih.gov/10859159
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(3)
The objective of this study was to examine the interrelationships between maternal and fetal plasma drug protein binding, umbilical blood flow (Q(um)), gestational age (GA), and maternal-fetal diphenhydramine (DPHM) clearances in chronically instrume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8650c1b3fc6702960356e36f10078621
https://pubmed.ncbi.nlm.nih.gov/10681371
https://pubmed.ncbi.nlm.nih.gov/10681371