Výsledky vyhledávání - "K. W. M. Lawrie"

16th International Isotope Society (UK group) Symposium

Autor: G. Åberg, F. I. Aigbirhio, E. Alexakis, N. Al-Maharik, M. Almi, Y. Ambacher, S. Andersson, A. Athlan, G. Badman, S. A. Baldwin, M. Baumann, I. R. Baxendale, N. P. Botting, R. A. Bragg, J. A. Brown, A. Burton, N. Bushby, K. Cable, G. Campbell, R. Carr, M. Carroll, L. Chen, M. Christlieb, P. Davies, G. J. Ellames, W. Ellis, C. Elmore, T. Fryatt, N. Geach, J. R. Harding, S. Hartmann, S. Harwood, J. J. Hayward, P. J. F. Henderson, R. B. Herbert, J. R. Heys, S. Hölzl, M. D. Hopkin, P. Horn, T. Ilyas, S. Irvine, S. D. Jackson, J. Jin, A. Keats, A. R. Kennedy, W. J. Kerr, M. O. Kitching, C. Landreau, S. Lanners, R. Lawrence, K. W. M. Lawrie, S. V. Ley, G. Little, W. J. S. Lockley, D. Maier, C. Manning, A. McNeill, D. A. Middleton, S. Montgomery, J. J. Morrison, L. Mrzljak, J. Newman, J. Newsome, N. Nikbin-Roudsari, G. N. Nilsson, M. F. Oldfield, S. G. Patching, D. J. Procter, G. Randall, A. A. Robertson, C. S. Rummel, D. Rustidge, R. Sherhod, N. Shipley, C. D. Smith, C. J. Smith, D. I. Smith, C. Song, L. Tamborini, I. Waterhouse, A. Watts, J. L. Werkheiser, G. Williams, C. L. Willis, P. Woodward, R. Yan, G. Young, Q. Zhang

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 51:247-261

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf6260af171d3f38543b97311ba343f4
https://doi.org/10.1002/jlcr.1513

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15th International Isotope Society (UK group) Symposium

Autor: F. I. Aigbirhio, E. Alexakis, J. Allen, J.-C. Baron, J. Beech, J. Beyer, J. P. Bloxsidge, N. P. Botting, L. Brichard, N. Bushby, K. Cable, J. C. Clark, L. K. Conway, G. Del Fiore, F. Dollé, G. Ellames, N. Feling, T. Fryatt, T. D. Fryer, A. D. Gee, K. Haajanen, J. R. Harding, S. J. Haswell, M. J. Hickey, D. W. Holt, J. Hooper, A. Johnston, G. Johnston, J. R. Jones, B. Kent, L. P. Kingston, S. L. Kitson, E. Knagg, B. Koch, N. Kuhnert, M. Lang, S. Lang-Fugmann, K. W. M. Lawrie, C. Lemaire, R. J. Lewis, W. J. S. Lockley, A. Luxen, C. O. Manning, A. N. Mather, P. Meath, J. Passchier, J. A. Perrie, A. Plenevaux, C. Plisson, K. C. Probst, D. O. Rees, L. Rivron, D. Rustidge, M. Rüth, J. M. Schofield, P. Scott, B. Sontag, P. Spiteller, A. V. Stachulski, W. Steglich, A. H. Wadsworth, P. Watts, L. Warburton, P. Weissberg, C. Wiles, D. J. Wilkinson, C. L. Willis

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 49:377-420

Meeting Programme Dr Nigel Botting [University of St Andrews, UK] – Isotopic Labelling of Lignan Phytoestrogens. Prof. Frederic Dolle [CEA PET Centre, Orsay, France] – Fluorine-18 Chemistry: A Selection of Recent Advances. Prof. Peter Scott [Univ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c6c3c4fa40f1a3dd4ce1493eb487691
https://doi.org/10.1002/jlcr.1056

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Tritiation of organic compounds by polymer-supported base catalysts

Autor: J. R. Brewer, J. R. Jones, K. W. M. Lawrie, D. Saunders, A. Simmonds

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 34:787-794

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dcb6d081f03c9ea5b95443397c7064e
https://doi.org/10.1002/jlcr.2580340812

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Tritiation of organic compounds by polymer-supported acid catalysts

Autor: K. W. M. Lawrie, J. R. Brewer, John R. Jones, Alan J. Simmonds, D. Saunders

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 34:391-400

A range of organic compounds have been tritiated (and in some cases deuteriated) via hydrogen isotope exchange reactions using polymer supported base catalysts. The problem of poor thermal stability of some commercially available anion exchange resin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::564a51c8e64b12de4524e98743e80b35
https://doi.org/10.1002/jlcr.2580340411

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The Synthesis of [methylenedioxy-14C]paroxetine BRL 29060A

Autor: D C Rustidge, K W M Lawrie

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 33:777-781

Paroxetine (1), BRL 29060A, a potent antidepressant, has been prepared radiolabelled with carbon-14 in the methylenedioxy group in 5 steps and 20.9% overall yield from [14C]dibromomethane. Two altenative preparations of 3,4-[methylenedioxy-14C]phenol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f716d5a2d3ed314a30bd4fc9e2c2d0c2
https://doi.org/10.1002/jlcr.2580330814

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The synthesis of [14C]pantoprazole - SK&F 96022Z. An H+/K+ ATPase inhibitor

Autor: D Saunders, C. E. A Johnston, K. W. M. Lawrie, A M Crowe

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 31:409-416

Pantoprazole 1, SK & F 96022Z, an H+/K+ ATPase inhibitor has been prepared, radiolabelled with carbon-14, in two positions, for drug metabolism studies. [Benzimidazole-2-14C]Pantoprazole in 4 steps from potassium ethyl [14C]xanthate, and [pyridylmeth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4476ab926a5f5c735832d0792d317c0
https://doi.org/10.1002/jlcr.2580310511

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The synthesis of [4-3H]oxiracetam - a novel nootropic agent

Autor: U Pfeiffer, A M Crowe, K W M Lawrie, D Saunders

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 29:103-109

The synthesis of [4-3H]oxiracetam (6) from ethyl 2-(4-chloro-3-oxo-butyramido)acetate (1) is described. Ethyl 2-(4-chloro-3-oxo-butyramido)-acetate (1) was reduced with sodium borotritide at Amersham International plc (TR5 tritiation service) to give

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::070f4b29eb35dad3c359f47ef36be272
https://doi.org/10.1002/jlcr.2580290114

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The synthesis of (−), (+) and (±)-[14C] SK&F 94836 a selective PDE III inhibitor

Autor: D Saunders, K. W. M. Lawrie, M A Armitage, S. Singh, A M Crowe, D. A. Rawlings

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 27:331-341

SK&F 94836, a selective PDE III inhibitor is a positive inotropic agent with vasodilator activity. The syntheses of (-)-[N-methyl-14C]SK&F 94836, (+)-[N-methyl-14C]SK&F 94836 and [carbonyl-14C] SK&F 94836 are described. The racemate, labelled in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a715efd994a6a370b26d2d889ad9560
https://doi.org/10.1002/jlcr.2580270311

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The synthesis of [14C] and [3H2] SK&F l-94901. A novel thyromimetic

Autor: K. W. M. Lawrie, D Saunders, A M Crowe

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 25:763-772

A novel thyromimetic SK&F L-94901, L-3,5-dibromo-3′-(6-oxo-1, 6-dihydro pyridazin-3-ylmethyl) thyronine, has been labelled with 14C and 3H for drug metabolism and nuclear binding studies. A six stage synthesis from [β-14C] tyrosine is described. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0bd552400bb8527b557447c72ec0e60
https://doi.org/10.1002/jlcr.2580250710

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