Výsledky vyhledávání

Inactivation of p53 increases the cytotoxicity of camptothecin in human colon HCT116 and breast MCF-7 cancer cells

Autor: M, Gupta, S, Fan, Q, Zhan, K W, Kohn, P M, O'Connor, Y, Pommier

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(9)

Camptothecin (CPT) derivatives are topoisomerase I (top1) inhibitors recently introduced as clinical agents. To explore the role of p53 in CPT-induced cytotoxicity, we examined CPT effects in two isogenic pairs of human cancer cell lines, MCF-7 breas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0d6ad42a05f363219bab3082403aa06
https://pubmed.ncbi.nlm.nih.gov/9815856

Zobrazit plný text záznamu

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function

Autor: R G, Shao, C X, Cao, T, Shimizu, P M, O'Connor, K W, Kohn, Y, Pommier

Publikováno v: Cancer research. 57(18)

7-Hydroxystaurosporine (UCN-01) is a selective protein kinase C inhibitor in clinical trial for cancer treatment. In this study, we found that nanomolar concentrations of camptothecin (CPT), a topoisomerase I inhibitor, arrest or delay cell cycle pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e314467dda239b1e936cbf5f64e728aa
https://pubmed.ncbi.nlm.nih.gov/9307289

Zobrazit plný text záznamu

Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors

Autor: J K, Buolamwini, K, Raghavan, M R, Fesen, Y, Pommier, K W, Kohn, J N, Weinstein

Publikováno v: Pharmaceutical research. 13(12)

A QSAR study based on electrotopological state (E-state) indices was conducted for a series of flavone HIV-1 integrase inhibitors to guide drug design.E-state indices formulated to encode electronic and topological information for each skeletal atom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39a7a071aeb0db0f37089f4deda6039d
https://pubmed.ncbi.nlm.nih.gov/8987091

Zobrazit plný text záznamu

Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells

Autor: F, Goldwasser, T, Shimizu, J, Jackman, Y, Hoki, P M, O'Connor, K W, Kohn, Y, Pommier

Publikováno v: Cancer research. 56(19)

Previous cell line comparisons indicated that neither S-phase fraction nor topoisomerase I (top1) levels are sufficient to predict camptothecin (CPT) cytotoxicity (F. Goldwasser el al., Cancer Res., 55: 2116-2121, 1995.). To identify new determinants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6bbd11ce933176625337d5d4995928ff
https://pubmed.ncbi.nlm.nih.gov/8813137

Zobrazit plný text záznamu

Potentiation of cisplatin cytotoxicity by 9-aminocamptothecin

Autor: F, Goldwasser, M, Valenti, R, Torres, K W, Kohn, Y, Pommier

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(4)

Camptothecin (CPT) derivatives are presently in ongoing Phase I/II clinical trials. The interactions between 9-aminocamptothecin (9AC) and cisplatin (CDDP) have been studied in the IGROV-1 human ovarian cancer cell line used in the National Cancer In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e364c0bd6b52a52537466f0375099b05
https://pubmed.ncbi.nlm.nih.gov/9816219

Zobrazit plný text záznamu

Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage

Autor: T, Shimizu, P M, O'Connor, K W, Kohn, Y, Pommier

Publikováno v: Cancer research. 55(2)

We have studied changes in cyclin A- and B1-dependent kinases during apoptosis induced in human promyelocytic leukemia (HL60) cells treated with the topoisomerase I inhibitor camptothecin. We found that cyclin B1/Cdc2 kinase activity transiently incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::507c4492f4d6769d06b1a18670019d5b
https://pubmed.ncbi.nlm.nih.gov/7812949

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání