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Expression of the human papillomavirus E7 oncogene during cell transformation is sufficient to induce susceptibility to lysis by activated macrophages

Autor: L Banks, F Moreau, K Vousden, D Pim, G Matlashewski

Publikováno v: The Journal of Immunology. 146:2037-2042

Human papillomaviruses (HPV), and in particular HPV type 16, are etiologic agents in the development of cervical cancer, which is the second most common form of cancer in women worldwide. Mammalian cells are susceptible to transformation in vitro by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0b883fd52d04778ff9c4481754082e0
https://doi.org/10.4049/jimmunol.146.6.2037

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Strategies for Studying Mouse and Human Immune Responses to Human Papillomavirus Type 16

Autor: J. Hickling, X. Zhu, S. Collins, Liquan Gao, K. Vousden, Hans J. Stauss, Elena Sadovnikova, Peter C. L. Beverley, L. Crawford, Benjamin M. Chain

Publikováno v: Ciba Foundation Symposium 187-Vaccines Against Virally Induced Cancers

Cytotoxic T lymphocytes (CTL) are an important protective mechanism in viral infection and can be effective against tumours. We have investigated the tumour-associated Ed and E7 genes of human papillomavirus type 16 as CTL targets. In H-2(b) mice we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::588fc657af66aef3444aba712e20cbbe
https://doi.org/10.1002/9780470514672.ch6

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p53 mediated apoptosis in HeLa cells: transcription dependent and independent mechanisms

Autor: Y, Haupt, S, Rowan, E, Shaulian, A, Kazaz, K, Vousden, M, Oren

Publikováno v: Leukemia. 11

The most frequent target for genetic alterations in human cancers is the p53 tumor suppressor gene. Mutations in p53 abrogate its ability to inhibit cell growth and to suppress tumor progression. The anti-proliferative activity of p53 can be mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::366fe6b2479846413e0073fea4187f49
https://pubmed.ncbi.nlm.nih.gov/9209383

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Both immunization with protein and recombinant vaccinia virus can stimulate CTL specific for the E7 protein of human papilloma virus 16 in H-2d mice

Autor: C. J. M. Melief, M. Tommasino, E. Sadovnikava, R. Rappuoli, X. Zhu, M. Kast, Peter C. L. Beverley, K. Vousden, Hans J. Stauss, L. Crawford

Publikováno v: Scandinavian journal of immunology. 42(5)

The transforming protein E7 of human papilloma virus type 16 can stimulate cytotoxic T lymphocytes (CTL) which can protect experimental animals against growth of E7 expressing tumour cells. In this study we compared CTL responses in mice immunized wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32728e1de091cc216a07208dc9f33410
https://pubmed.ncbi.nlm.nih.gov/7481562

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Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein

Autor: S, Bates, D, Parry, L, Bonetta, K, Vousden, C, Dickson, G, Peters

Publikováno v: Oncogene. 9(6)

Cyclins D1, D2 and D3 are thought to function in the G1 phase of the cell division cycle by regulating the activity of cyclin-dependent protein kinases. All three D-type cyclins can be shown to associate with two specific kinases, cdk4 and cdk6, prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3ce18b642ac3026177f173986dcdd59
https://pubmed.ncbi.nlm.nih.gov/8183557

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