Zobrazeno 1 - 10
of 31
pro vyhledávání: '"K. Van Derpoorten"'
Autor:
J. H. Poupaert, Robert Snoeck, H Ucar, K. Van Derpoorten, Jan Balzarini, Erik De Clercq, Graciela Andrei
Publikováno v:
Antiviral Chemistry and Chemotherapy. 10:87-97
The synthesis and antiviral activity of an original series of 6-benzoyl-benzoxazolin-2-one and 6-benzoyl-benzothiazolin-2-one derivatives are described. Several compounds were found to have a selective inhibitory activity against human cytomegaloviru
Autor:
Bernard Masereel, James P. Stables, Paul Depovere, H Ucar, K. Van Derpoorten, J. Delarge, S. Cacciaguerra, Jacques H. Poupaert, M. Isa, Santi Spampinato
Publikováno v:
Journal of Medicinal Chemistry. 41:1138-1145
A series of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives were synthesized and evaluated for anticonvulsant activity. The compounds were assayed, intraperitoneally in mice and per os in rats, against seizures induced by maximal electrosho
Autor:
Paul Depovere, M. Isa, Jacques H. Poupaert, Daniel Lesieur, Jacques Delarge, H Ucar, K. Van Derpoorten, Bernard Masereel
Publikováno v:
Tetrahedron. 54:1763-1772
6-Acyl-2(3H)-benzoxazolone and 6-acyl-2(3H)-benzothiazolone derivatives have particularly interesting anti-inflammatory, antiepileptic, analgesic and antiviral properties. in this study, we report an original method of acylation on the 6-position of
Autor:
M Kanyonyo, J. H. Poupaert, O. Diouf, K. Van Derpoorten, A. Gozzo, D. M. Lambert, Philippe Levêque, Joseph Vamecq
Publikováno v:
ChemInform. 27
Autor:
Daniel Lesieur, M. Isa, Didier M. Lambert, H Ucar, M Kanyonyo, K. Van Derpoorten, J. H. Poupaert
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 28
Autor:
Paul Depovere, Bernard Masereel, Jacques Delarge, Daniel Lesieur, M. Isa, Jacques H. Poupaert, H Ucar, K. Van Derpoorten
Publikováno v:
ChemInform. 29
6-Acyl-2(3H)-benzoxazolone and 6-acyl-2(3H)-benzothiazolone derivatives have particularly interesting anti-inflammatory, antiepileptic, analgesic and antiviral properties. in this study, we report an original method of acylation on the 6-position of
Autor:
J. Delarge, Jacques H. Poupaert, Paul Depovere, K. Van Derpoorten, James P. Stables, H Ucar, S. Cacciaguerra, Santi Spampinato, Bernard Masereel, M. Isa
Publikováno v:
ChemInform. 29
A series of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives were synthesized and evaluated for anticonvulsant activity. The compounds were assayed, intraperitoneally in mice and per os in rats, against seizures induced by maximal electrosho
Autor:
Luc Dasnois, André Trouet, E R Lewis, Karim Lebtahi, K. Van Derpoorten, T J Lobl, Vincent Dubois, Anne-Marie Fernandez, D Shochat, S Gangwar, Cecilia Oliyai
Publikováno v:
Journal of medicinal chemistry. 44(22)
Intravenous administration of N-(beta-alanyl-L-leucyl-L-alanyl-L-leucyl)doxorubicin (4) induces an acute toxic reaction, killing animals in a few minutes. This results from its positive charge at physiological pH combined with its propensity to form
Autor:
A, Trouet, A, Passioukov, K, Van derpoorten, A M, Fernandez, J, Abarca-Quinones, R, Baurain, T J, Lobl, C, Oliyai, D, Shochat, V, Dubois
Publikováno v:
Cancer research. 61(7)
Oligopeptidic derivatives of anthracyclines unable to penetrate cells were prepared and screened for their stability in human blood and their reactivation by peptidases secreted by cancer cells. N-beta-alanyl-L-leucyl-L-alanyl-L-leucyl-doxorubicin wa