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Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs

Autor: Shamika Danzy, Virginia K. Vachon, Esther N. Park, Graeme L. Conn, Samantha L. Schwartz, Anice C. Lowen

Publikováno v: Nucleic Acids Research

2′-5′-Oligoadenylate synthetases (OAS) are innate immune sensors of cytosolic double-stranded RNA (dsRNA) and play a critical role in limiting viral infection. dsRNA binding induces allosteric structural changes in OAS1 that reorganize its cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a093557dc2f53f59e701219494fa269
http://europepmc.org/articles/PMC7367156

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MP48: White blood cells count and C-reactive protein performance to identify severe bacterial infection in the fever without a source workup of infants 22 to 60 days old

Autor: Simon Berthelot, G. Gravel, L. Lajeunesse, M. Giguère, J. Ouellet-Pelletier, J. Morin, R. Turgeon, K. Vachon

Publikováno v: CJEM. 21:S59-S60

Introduction: Identification of severe bacterial infections (SBI) among infants presenting to the emergency department (ED) for fever without a source (FWS) remains challenging. Controversies persist on the usefulness of blood biomarkers, especially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3fd373d40a594db0c9f56aef0077f2a
https://doi.org/10.1017/cem.2019.183

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PL04: Comparison of the cost and the quality of the care provided to low acuity patients in an emergency department and a walk-in clinic

Publikováno v: CJEM. 21:S6

Introduction: Low acuity patients have been controversially tagged as a source of emergency department (ED) misuse. Authorities for many Canadian health regions have set up policies so these patients preferably present to walk-in clinics (WIC). We co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f65f2cf67969022a5b215b6840520f7
https://doi.org/10.1017/cem.2019.43

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P056: Is lumbar puncture mandatory in the workup of infants 22 to 60 days old presenting to the emergency department with a fever without a source?

Autor: L. Lajeunesse, J. Ouellet-Pelletier, R. Turgeon, M. Mallet, Simon Berthelot, M. Giguère, G. Gravel, J. Morin, K. Vachon

Publikováno v: CJEM. 21:S83

Introduction: Fever is a common presenting complaint in the emergency department (ED). Febrile infants are at particularly high risk of serious bacterial infection including bacterial meningitis. Unfortunately, recommendations as to when to perform a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0115c2f318a33fe8862ae3908eb897b8
https://doi.org/10.1017/cem.2019.247

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A novel RNA molecular signature for activation of 2'-5' oligoadenylate synthetase-1

Autor: Brenda M. Calderon, Graeme L. Conn, Virginia K. Vachon

Publikováno v: Nucleic Acids Research

Human 2'-5' oligoadenylate synthetase-1 (OAS1) is central in innate immune system detection of cytoplasmic double-stranded RNA (dsRNA) and promotion of host antiviral responses. However, the molecular signatures that promote OAS1 activation are curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4ea7abbd99ef4cbfc56257e9768a72
https://pubmed.ncbi.nlm.nih.gov/25477390

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Dissection of the adenoviral VA RNAI central domain structure reveals minimum requirements for RNA-mediated inhibition of PKR

Autor: Samantha L. Schwartz, Jo L. Wilson, S. Sunita, Virginia K. Vachon, Graeme L. Conn

Publikováno v: The Journal of biological chemistry. 289(33)

Virus-associated RNA I (VA RNAI) is a short (∼160-nucleotide) non-coding RNA transcript employed by adenoviruses to subvert the innate immune system protein double-stranded RNA-activated protein kinase (PKR). The central domain of VA RNAI is propos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0566fe10ebf6f98d8888158a43bd07
https://pubmed.ncbi.nlm.nih.gov/24970889

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Akademický článek

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Plasmid template design and in vitro transcription of short RNAs within a 'structure cassette' for structure probing experiments

Autor: Virginia K, Vachon, Graeme L, Conn

Publikováno v: Methods in molecular biology (Clifton, N.J.). 941

Chemical and enzymatic RNA structure probing methods are important tools for examining RNA secondary and tertiary structures and their interactions with proteins, small molecules, and ions. The recently developed "Selective 2'-Hydroxyl Acylation Anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b6fb33122d8f6546da234e107d91f87
https://pubmed.ncbi.nlm.nih.gov/23065560

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Plasmid Template Design and In Vitro Transcription of Short RNAs Within a 'Structure Cassette' for Structure Probing Experiments

Autor: Graeme L. Conn, Virginia K. Vachon

Publikováno v: Recombinant and In Vitro RNA Synthesis ISBN: 9781627031127

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f13732bf3d53e0bf3f1f519d8edf3dc
https://doi.org/10.1007/978-1-62703-113-4_12

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