RNA sequencing of db/db mice liver identifies lncRNA H19 as a key regulator of gluconeogenesis and hepatic glucose output

Autor: Neha Goyal, Ambily Sivadas, K. V. Shamsudheen, Rijith Jayarajan, Ankit Verma, Sridhar Sivasubbu, Vinod Scaria, Malabika Datta

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract Liver plays a key role in maintaining glucose homeostasis and impaired hepatic glucose metabolism is associated with type 2 diabetes. In the present study, we used RNA sequencing to profile the transcriptome of the livers of diabetic db/db m

Externí odkaz: https://doaj.org/article/e368d4dd85474897b1a7477fd6fe2d52

LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy

Autor: Sushma Vishwakarma, Archana Vats, Sridhar Sivasubbu, Binukumar B K, Shantanu Sengupta, Abhishek Pateria, Gyan Ranjan, Paras Sehgal, Rahul C. Bhoyar, K. V. Shamsudheen, Arjun Ray, Mudit Tyagi, Ambily Sivadas, Rajeev R Pappuru, Saumya Jakati, Elvin Leonard, Jyoti Tanwar, Rajender K. Motiani, Inderjeet Kaur, Samatha Mathew, Vinod Scaria, Subhabrata Chakrabarti, Mukesh Kumar Lalwani

Publikováno v: The EMBO Journal
Sehgal, P, Mathew, S, Sivadas, A, Ray, A, Tanwar, J, Vishwakarma, S, Ranjan, G, Shamsudheen, K V, Bhoyar, R C, Pateria, A, Leonard, E, Lalwani, M, Vats, A, Pappuru, R R, Tyagi, M, Jakati, S, Sengupta, S, B K, B, Chakrabarti, S, Kaur, I, Motiani, R K, Scaria, V & Sivasubbu, S 2021, ' LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy ', EMBO Journal, vol. 40, no. 15, e107134 . https://doi.org/10.15252/embj.2020107134

Long non‐coding RNAs (lncRNAs) are emerging as key regulators of endothelial cell function. Here, we investigated the role of a novel vascular endothelial‐associated lncRNA (VEAL2) in regulating endothelial permeability. Precise editing of veal2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a575ee38903807a1a086308dcffe48
https://pubmed.ncbi.nlm.nih.gov/34180064

Genome and transcriptome analysis of the mealybug Maconellicoccus hirsutus: A model for genomic Imprinting

Autor: Sridhar Sivasubbu, Ankita Narang, K. V. Shamsudheen, Parul Gulati, Rajesh Pandey, Vani Brahmachari, Surbhi Kohli, Jayant Maini, Vinod Scaria

In mealybugs, transcriptional inactivation of the entire paternal genome in males, due to genomic imprinting, is closely correlated with sex determination. The sequencing, de-novo assembly and annotation of the mealybug, Maconellicoccus hirsutus geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87fae39bfb519e442c1e49b5f9a31468
https://doi.org/10.1101/2020.05.22.110437

Maternal vitamin B

Autor: Vinay Singh, Tanwar, Sourav, Ghosh, Satish, Sati, Subhoshree, Ghose, Lovejeet, Kaur, Kalle Anand, Kumar, K V, Shamsudheen, Ashok, Patowary, Meghna, Singh, V, Jyothi, Pujitha, Kommineni, Sridhar, Sivasubbu, Vinod, Scaria, Manchala, Raghunath, Rakesh, Mishra, Giriraj Ratan, Chandak, Shantanu, Sengupta

Publikováno v: Molecular and cellular biochemistry. 468(1-2)

Vitamin B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48bd543540745bc6680089980cd12911
https://pubmed.ncbi.nlm.nih.gov/32189172

Loss of function mutation in the P2X7, a ligand-gated ion channel gene associated with hypertrophic cardiomyopathy

Autor: Benrithung Murry, Rijith Jayarajan, Balram Bhargava, Vinod Scaria, Sandeep Seth, Vadlamudi Raghavendra Rao, K. V. Shamsudheen, Ankit Verma, Ali Raza, Soumi Das, Amitabh Biswas, Sridhar Sivasubbu, Mitali Kapoor

Publikováno v: Purinergic signalling. 15(2)

Hypertrophic cardiomyopathy (HCM) is an inherited heart failure condition, mostly found to have genetic abnormalities, and is a leading cause of sudden death in young adults. Whole exome sequencing should be given consideration as a molecular diagnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6705378102aba3536c33ee12c5875f1e
https://pubmed.ncbi.nlm.nih.gov/31152337