Zobrazeno 1 - 10
of 2 065
pro vyhledávání: '"K. Ulrich"'
Autor:
Jonathan E. Tullis, K. Ulrich Bayer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Dendritic spines are the postsynaptic compartments of excitatory synapses, however, a substantial subset of spines additionally receives inhibitory input. In such dually innervated spines (DiSs), excitatory long-term potentiation (LTP) mecha
Externí odkaz:
https://doaj.org/article/5b0d5a5caf1c4e19ab0aa6e4afbc046d
Autor:
Jonathan E. Tullis, K. Ulrich Bayer
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106723- (2023)
Summary: The death-associated protein kinase 1 (DAPK1) regulates the synaptic movement of the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII). Synaptic CaMKII accumulation is mediated via binding to the NMDA-receptor subunit GluN2B and is
Externí odkaz:
https://doaj.org/article/2181192e239a48d4b8135d618406fe50
Publikováno v:
Geofluids, Vol 2023 (2023)
Groundwater with total dissolved sulphide concentrations in excess of 1.0×10−4 mol L−1 3 mg L−1 is relatively common at intermediate depths in sedimentary basins. However, the mechanisms responsible for the formation and spatial distribution o
Externí odkaz:
https://doaj.org/article/8e0956132dbd486e94c93bfa63946155
Autor:
Carolyn Nicole Brown, Nicole L. Rumian, Jonathan E. Tullis, Steven J. Coultrap, K. Ulrich Bayer
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104368- (2022)
Summary: Aβ bears homology to the CaMKII regulatory domain, and peptides derived from this domain can bind and disrupt the CaMKII holoenzyme, suggesting that Aβ could have a similar effect. Notably, Aβ impairs the synaptic CaMKII accumulation that
Externí odkaz:
https://doaj.org/article/14510bbf6546474285d2a13c91624426
Autor:
Carolyn Nicole Brown, Sarah G. Cook, Hillary F. Allen, Kevin C. Crosby, Tarjinder Singh, Steven J. Coultrap, K. Ulrich Bayer
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103184- (2021)
Summary: The Ca2+/Calmodulin-dependent protein kinase II (CaMKII) is a central regulator of synaptic plasticity and has been implicated in various neurological conditions, including schizophrenia. Here, we characterize six different CaMKIIα variants
Externí odkaz:
https://doaj.org/article/99bee0eeeb324359bf2282e2f6ae69cf
Autor:
Jonathan E. Tullis, Olivia R. Buonarati, Steven J. Coultrap, Ashley M. Bourke, Erika L. Tiemeier, Matthew J. Kennedy, Paco S. Herson, K. Ulrich Bayer
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103214- (2021)
Summary: Binding of two different CaM kinases, CaMKII and DAPK1, to the NMDA-type glutamate receptor (NMDAR) subunit GluN2B near S1303 has been implicated in excitotoxic/ischemic neuronal cell death. The GluN2BΔCaMKII mutation (L1298A, R1300Q) is ne
Externí odkaz:
https://doaj.org/article/f415611452a44fc8862991682f4e7cfa
Autor:
Felix F.L. Reichel, MD, Fabian Wozar, MD, Immanuel Seitz, MD, Alex Ochakovski, MD, K. Ulrich Bartz-Schmidt, MD, Tobias Peters, MD, M. Dominik Fischer, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 1, Iss 3, Pp 100050- (2021)
Purpose: Subretinal injections (SRis) are commonly used in retinal gene therapy procedures to deliver adeno-associated virus (AAV) to photoreceptors and retinal pigment epithelial cells. We present an optimized surgical protocol to minimize off-targe
Externí odkaz:
https://doaj.org/article/58ca6f62b107433f96f9c3709ee8f9ca
Publikováno v:
Frontiers in Water, Vol 3 (2021)
Placement methods and material availability during waste rock pile (WRP) construction may create significant heterogeneities in physical and geochemical parameters (such as grain size, permeability, mineralogy, and reactivity) and influence the inter
Externí odkaz:
https://doaj.org/article/5e2e7812695d4231935117324f88cdea
Autor:
Bas Vriens, Elliott K. Skierszkan, Melanie St-Arnault, Kristin Salzsauler, Celedonio Aranda, K. Ulrich Mayer, Roger D. Beckie
Publikováno v:
ACS Omega, Vol 4, Iss 6, Pp 10205-10215 (2019)
Externí odkaz:
https://doaj.org/article/6b2c1f9cf14749cea59761d8a3c426d4
Autor:
Olivia R. Buonarati, Sarah G. Cook, Dayton J. Goodell, Nicholas E. Chalmers, Nicole L. Rumian, Jonathan E. Tullis, Susana Restrepo, Steven J. Coultrap, Nidia Quillinan, Paco S. Herson, K. Ulrich Bayer
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 1-8.e4 (2020)
Summary: DAPK1 binding to GluN2B was prominently reported to mediate ischemic cell death in vivo. DAPK1 and CaMKII bind to the same GluN2B region, and their binding is mutually exclusive. Here, we show that mutating the binding region on GluN2B (L129
Externí odkaz:
https://doaj.org/article/0747266e16f346cea222f1e38a2efe82