Zobrazeno 1 - 10
of 463
pro vyhledávání: '"K. Tuominen"'
Publikováno v:
MethodsX, Vol 6, Iss , Pp 2384-2395 (2019)
In experimental deep brain stimulation of the subthalamic nucleus (STN HFS), stimulation currents just below the appearance threshold of stimulation-induced dyskinesias has often been used. The behavioral effect of STN HFS can be measured by the reve
Externí odkaz:
https://doaj.org/article/f8c7d3d77d894b25a5219dde14e64527
Autor:
Saara Lautala, Riccardo Provenzani, Ilari Tarvainen, Katia Sirna, S. Tuuli Karhu, Evgeni Grazhdankin, Antti K. Lehtinen, Hanan Sa’d, Artturi Koivuniemi, Henri Xhaard, Raimo K. Tuominen, Virpi Talman, Alex Bunker, Jari Yli-Kauhaluoma
Publikováno v:
Journal of Medicinal Chemistry. 66:4588-4602
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5245c1c32703c57ea1735d9e5ee0a4b
https://doi.org/10.1021/acs.jmedchem.2c01448
https://doi.org/10.1021/acs.jmedchem.2c01448
Autor:
Maria H. Jäntti, Virpi Talman, Kati Räsänen, Ilari Tarvainen, Hannu Koistinen, Raimo K. Tuominen
Publikováno v:
FEBS Open Bio, Vol 8, Iss 5, Pp 817-828 (2018)
Prostate cancer is one of the most common cancers in men. Although it has a relatively high 5‐year survival rate, development of resistance to standard androgen‐deprivation therapy is a significant clinical problem. Therefore, novel therapeutic s
Externí odkaz:
https://doaj.org/article/04c1350fde84491bb7286f40dc0a2c00
Autor:
Anna-Maija Penttinen, Ilmari Parkkinen, Merja H. Voutilainen, Maryna Koskela, Susanne Bäck, Anna Their, Christopher T. Richie, Andrii Domanskyi, Brandon K. Harvey, Raimo K. Tuominen, Liina Nevalaita, Mart Saarma, Mikko Airavaara
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Glial cell line-derived neurotrophic factor (GDNF) is one of the most studied neurotrophic factors. GDNF has two splice isoforms, full-length pre-α-pro-GDNF (α-GDNF) and pre-β-pro-GDNF (β-GDNF), which has a 26 amino acid deletion in the pro-regio
Externí odkaz:
https://doaj.org/article/0e3d168a5c6044e79f9fcb0e3793f8c3
Autor:
Riccardo Provenzani, Ilari Tarvainen, Giulia Brandoli, Antti Lempinen, Sanna Artes, Ainoleena Turku, Maria Helena Jäntti, Virpi Talman, Jari Yli-Kauhaluoma, Raimo K Tuominen, Gustav Boije Af Gennäs
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195668 (2018)
Protein kinase C (PKC) isoforms play a pivotal role in the regulation of numerous cellular functions, making them extensively studied and highly attractive drug targets. Utilizing the crystal structure of the PKCδ C1B domain, we have developed hydro
Externí odkaz:
https://doaj.org/article/011c3ac1fd414b3695e15b73be2e16e1
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 380:54-62
Colorectal cancer is the third most commonly occurring cancer in men and the second in women. The global burden of colorectal cancer is projected to increase to over 2 million new cases with over 1 million deaths within the next 10 years, and there i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e197dc12c449a14cb45813d07f95615
https://doi.org/10.1124/jpet.121.000848
https://doi.org/10.1124/jpet.121.000848
Autor:
Merja H. Voutilainen, Yulia Sidorova, Konsta Valkonen, Raimo K. Tuominen, Mart Saarma, Mati Karelson, Tanel Visnapuu, Juho-Matti Renko, Arun Kumar Mahato
Publikováno v:
Journal of Parkinson's Disease
Background: Parkinson’s disease (PD) is a progressive neurological disorder where loss of dopamine neurons in the substantia nigra and dopamine depletion in the striatum cause characteristic motor symptoms. Currently, no treatment is able to halt t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570e429e151ab3fe8e10b49a76920657
https://doi.org/10.3233/jpd-202400
https://doi.org/10.3233/jpd-202400
Autor:
Riccardo Provenzani, Alex Bunker, Raimo K. Tuominen, Virpi Talman, Jari Yli-Kauhaluoma, Saara Lautala, Waldemar Kulig, Artturi Koivuniemi, Tomasz Róg
Publikováno v:
Journal of Chemical Information and Modeling. 60:5624-5633
Increasing protein kinase C (PKC) activity is of potential therapeutic value. Its activation involves an interaction between the C1 domain and diacylglycerol (DAG) at intracellular membrane surfaces; DAG mimetics hold promise as new drugs. We previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f707b5c10afd3cc558e469a610e2f9
https://doi.org/10.1021/acs.jcim.0c00624
https://doi.org/10.1021/acs.jcim.0c00624
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